Landscape and clinical significance of long noncoding <scp>RNAs</scp> involved in multiple myeloma expressed fusion transcripts

Amundarain, Ane; Valcárcel, Luis Vítores; Ordóñez, Raquel; Gárate, Leire; Miranda, Estíbaliz; Cendoya, Xabier; Carrasco‐Leon, Arantxa; Calasanz, Marı́a José; Meydan, Cem; Mason, Christopher E.; Melnick, Ari; Rodríguez‐Otero, Paula; Martín‐Subero, José I.; Miguel, Jesús F. San; Planes, Francisco J.; Prósper, Felipe; Agirre, Xabier

doi:10.1002/ajh.26450

Search citation statements

Order By: Relevance

Paper Sections

Select...

Epigenetic Changes In Mesenchymal Stem Cells and Multiple My...1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An analogous action could be performed by other forms of non-coding genetic material, such as long non-coding RNA, whose altered distribution is known in MM patients [ 101 , 102 ].…”

Section: Epigenetic Changes In Mesenchymal Stem Cells and Multiple My...mentioning

confidence: 99%

Epigenetic Crosstalk between Malignant Plasma Cells and the Tumour Microenvironment in Multiple Myeloma

Allegra

Casciaro

Barone

et al. 2022

Cancers

View full text Add to dashboard Cite

In multiple myeloma, cells of the bone marrow microenvironment have a relevant responsibility in promoting the growth, survival, and drug resistance of multiple myeloma plasma cells. In addition to the well-recognized role of genetic lesions, microenvironmental cells also present deregulated epigenetic systems. However, the effect of epigenetic changes in reshaping the tumour microenvironment is still not well identified. An assortment of epigenetic regulators, comprising histone methyltransferases, histone acetyltransferases, and lysine demethylases, are altered in bone marrow microenvironmental cells in multiple myeloma subjects participating in disease progression and prognosis. Aberrant epigenetics affect numerous processes correlated with the tumour microenvironment, such as angiogenesis, bone homeostasis, and extracellular matrix remodelling. This review focuses on the interplay between epigenetic alterations of the tumour milieu and neoplastic cells, trying to decipher the crosstalk between these cells. We also evaluate the possibility of intervening specifically in modified signalling or counterbalancing epigenetic mechanisms.

show abstract

“…An analogous action could be performed by other forms of non-coding genetic material, such as long non-coding RNA, whose altered distribution is known in MM patients [ 101 , 102 ].…”

Section: Epigenetic Changes In Mesenchymal Stem Cells and Multiple My...mentioning

confidence: 99%

Epigenetic Crosstalk between Malignant Plasma Cells and the Tumour Microenvironment in Multiple Myeloma

Allegra

Casciaro

Barone

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

Landscape and clinical significance of long noncoding RNAs involved in multiple myeloma expressed fusion transcripts

Cited by 1 publication

References 6 publications

Epigenetic Crosstalk between Malignant Plasma Cells and the Tumour Microenvironment in Multiple Myeloma

Epigenetic Crosstalk between Malignant Plasma Cells and the Tumour Microenvironment in Multiple Myeloma

Contact Info

Product

Resources

About