Landmines in the Golan Heights: a patient's perspective

Kreniske, Jonah Susser; Harris, Asaf; Safadi, Wajdi

doi:10.1136/bcr-2014-205756

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Thus, it might be used in a variety of fields, which have been categorized into three sections: Bio-sensing: microbiomes are continually reacting to environment changes, which means they have the ability to detect and respond to them [ 38 ]. This method allows tuning of the sensing elements towards certain species of bacteria (shown in Figure A6 ), which can be used to mark their presence in the environment or receive better signal to noire ratios (SNR) [ 39 , 40 , 41 , 42 , 43 , 44 ]. Bio production/Bio degradation: the microbiome’s functional effect on the ecosystem is assisted through biomolecule production and destruction.…”

Section: Discussionmentioning

confidence: 99%

“…Bio-sensing: microbiomes are continually reacting to environment changes, which means they have the ability to detect and respond to them [ 38 ]. This method allows tuning of the sensing elements towards certain species of bacteria (shown in Figure A6 ), which can be used to mark their presence in the environment or receive better signal to noire ratios (SNR) [ 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

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Modulating Gene Expression within a Microbiome Based on Computational Models

Levi

Rippin

Tulila

et al. 2022

Biology

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Recent research in the field of bioinformatics and molecular biology has revealed the immense complexity and uniqueness of microbiomes, while also showcasing the impact of the symbiosis between a microbiome and its host or environment. A core property influencing this process is horizontal gene transfer between members of the bacterial community used to maintain genetic variation. The essential effect of this mechanism is the exposure of genetic information to a wide array of members of the community, creating an additional “layer” of information in the microbiome named the “plasmidome”. From an engineering perspective, introduction of genetic information to an environment must be facilitated into chosen species which will be able to carry out the desired effect instead of competing and inhibiting it. Moreover, this process of information transfer imposes concerns for the biosafety of genetic engineering of microbiomes as exposure of genetic information into unwanted hosts can have unprecedented ecological impacts. Current technologies are usually experimentally developed for a specific host/environment, and only deal with the transformation process itself at best, ignoring the impact of horizontal gene transfer and gene-microbiome interactions that occur over larger periods of time in uncontrolled environments. The goal of this research was to design new microbiome-specific versions of engineered genetic information, providing an additional layer of compatibility to existing engineering techniques. The engineering framework is entirely computational and is agnostic to the selected microbiome or gene by reducing the problem into the following set up: microbiome species can be defined as wanted or unwanted hosts of the modification. Then, every element related to gene expression (e.g., promoters, coding regions, etc.) and regulation is individually examined and engineered by novel algorithms to provide the defined expression preferences. Additionally, the synergistic effect of the combination of engineered gene blocks facilitates robustness to random mutations that might occur over time. This method has been validated using both computational and experimental tools, stemming from the research done in the iGEM 2021 competition, by the TAU group.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Modulating Gene Expression within a Microbiome Based on Computational Models

Levi

Rippin

Tulila

et al. 2022

Biology

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“…Kreniske et al describe a case of a child wounded by a landmine to advocate for, “community landmine awareness and safety education, as well as comprehensive mine removal,” to improve health and economic viability in endemic regions ( 86 ). The case of delayed diagnosis of tuberculosis is discussed in a case report of an indigenous man in Guatemala.…”

Section: Changing Behavior Through Global Health Case Reportsmentioning

confidence: 99%

Global Health Education and Advocacy: Using BMJ Case Reports to Tackle the Social Determinants of Health

Douthit¹,

Biswas²

2018

Front. Public Health

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Since 2013, BMJ Case Reports () has published over 70 global health case reports from five continents, written by doctors, nurses, students, and allied health professionals. These cases, a burgeoning repository of evidence of how real patients are affected by disease, trauma, violence, sexual assault, conflict, migration, adverse living and working conditions, and poor access to health care, discuss, in addition to clinicopathological findings, the global health problems affecting each patient. The global health problem analysis examines the problems of individual patients, critically appraises the literature, and describes actual and potential solutions for the patient, the local community, and patients affected by similar issues across the world. At present global health literature and learning materials lack a patient focus and real-life context in the analysis of global health problems. BMJ Case Reports global health case reports are a unique and important tool to learn about and advocate for change in the social, political, cultural, and financial determinants of health as they affect real patients. This growing evidence base brings together clinicians, local service providers, policy makers, and government and non-governmental institutions to effect real change in patients’ lives toward improving health. Each global health case report is an excellent resource for learning, and together, these case reports provide essential reading for anyone embarking on a career in global health, and writing their own case report. The online course () at BMJ Case Reports uses these cases and is free to access.

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“…Among those beliefs most relevant to the case presently described are an emphasis on a satisfied acceptance of fate preordained by God, and a foundational belief in mutual aid manifest as “protection and aid to brethren in faith.”4 Previous reports on the Golan Heights Druze communities have emphasised the role of strong community ties based on the principle of mutual aid and religious faith in a predetermined destiny as important for patients and families coping with challenging medical circumstances 5…”

Section: Literature Reviewmentioning

confidence: 99%

Family as the primary caregiver: palliative care in the Golan Heights

et al. 2015

Self Cite

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Palliative care is recognised by the WHO as an essential component of care for the seriously ill. Geographically isolated and historically underserved communities, particularly from ethnic minority groups, face obstacles in obtaining adequate palliative care. This case involves the care of a 26-year-old Druze man suffering from a terminal cancer in his Golan Heights village. Local physicians were able to train the patient's father in a palliative care capacity. In the effort of capacity building, the physician and palliative care team also aided the aggrieved family in the process of coping. Robust support networks, both at state and community levels, facilitated the care provided. In showcasing the role of the national and local safety net in activating and building community resources to address a dearth of palliative care services in disadvantaged regions, this case models a potentially effective community-based approach to palliative care for patients from underserved populations.

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Landmines in the Golan Heights: a patient's perspective

Cited by 4 publications

References 4 publications

Modulating Gene Expression within a Microbiome Based on Computational Models

Modulating Gene Expression within a Microbiome Based on Computational Models

Global Health Education and Advocacy: Using BMJ Case Reports to Tackle the Social Determinants of Health

Family as the primary caregiver: palliative care in the Golan Heights

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