Landiolol does not enhance the effect of ischemic preconditioning in isolated rat hearts

Abstract

IPC and landiolol have cardioprotective effects on ischemia-reperfusion injury in isolated rat hearts, but pretreatment with landiolol does not enhance the cardioprotective effect of IPC.

Interaction of Risk Factors, Comorbidities, and Comedications with Ischemia/Reperfusion Injury and Cardioprotection by Preconditioning, Postconditioning, and Remote Conditioning

“…In contrast, landilol treatment during ischemic preconditioning in isolated rat hearts (Yu et al, 2010) or intravenous atenolol or esmolol, given before ischemia or at reperfusion, did not interfere with protection afforded by ischemic preconditioning in rabbit hearts in vivo (Iliodromitis et al, 2004). However, esmolol abolished the infarct size reduction achieved by fluraneinduced anesthetic preconditioning (Lange et al, 2006).…”