2009
DOI: 10.1016/j.jad.2008.07.020
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Lamotrigine in bipolar disorder: Results of a mirror-image evaluation using the NIMH Lifechart-Methodology

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Cited by 10 publications
(5 citation statements)
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“…Mild to moderate rash was reported in five patients (13.5%) and resolved in each case on withdrawal of LTG. Finally, a ‘mirror-image’ comparison of patient symptom profiles before and after initiation of LTG 57 found no significant change in the number of manic, depressive or mixed episodes, or the number of switches from depression to mania, and no significant improvements in CGI-BP, YMRS, Inventory of Depressive Symptomatology-Clinician or GAF scores. Although symptoms did not appear to improve, the mean duration of depressive and mixed episodes was significantly reduced ( p = 0.006 and p < 0.001, respectively).…”
Section: Resultsmentioning
confidence: 96%
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“…Mild to moderate rash was reported in five patients (13.5%) and resolved in each case on withdrawal of LTG. Finally, a ‘mirror-image’ comparison of patient symptom profiles before and after initiation of LTG 57 found no significant change in the number of manic, depressive or mixed episodes, or the number of switches from depression to mania, and no significant improvements in CGI-BP, YMRS, Inventory of Depressive Symptomatology-Clinician or GAF scores. Although symptoms did not appear to improve, the mean duration of depressive and mixed episodes was significantly reduced ( p = 0.006 and p < 0.001, respectively).…”
Section: Resultsmentioning
confidence: 96%
“…A ‘mirror-image’ comparison of patient symptom profiles before and after initiation of LTG 57 found no significant change in the number of manic, depressive or mixed episodes or significant improvements in CGI-BP, YMRS, Inventory of Depressive Symptomatology-Clinician or GAF scores.…”
Section: Resultsmentioning
confidence: 99%
“…Additionally, the use of lamotrigine in the treatment of acute BPD is limited by the necessity of slow dose titration, due to the risk of Stevens–Johnson syndrome. Nevertheless, considering the generally favorable side effect profile ( 44 ), the efficacy in the prophylaxis of depressive episodes, and the positive results for lamotrigine as adjunctive treatment to lithium or quetiapine in the acute episode ( 45 47 ), it is surprising that it is not prescribed more often. Previous studies about prescription practice in the 2000s showed considerable higher prescription rates in outpatients ( 48 ), as well as in inpatients ( 23 ).…”
Section: Discussionmentioning
confidence: 99%
“…One study has employed this design over an 18‐month period and found no effect of lamotrigine . However, a small sample size of 20 patients was examined retrospectively and prospectively, hence limiting the inferences that can be made.…”
Section: Quo Vadismentioning
confidence: 99%