Lamotrigine for schizophrenia

Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments

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Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments

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Efficacy of 42 Pharmacologic Cotreatment Strategies Added to Antipsychotic Monotherapy in Schizophrenia

“…Of 3397 search engine hits, 29 meta-analyses were included, creating a total of 381 meta-analyzed trials and 19 321 study participants and providing meta-analytic data for antipsychotic drug treatments combined with 42 different psychotropic medications. Among these combinations, 37 were of any antipsychotic drug (not excluding clozapine) with a second psychotropic medication and 5 were specifically of combinations with clozapine (eFigure 1 in the Supplement). All included meta-analyses designated the primary outcome as total psychopathology except for 2 (glutamate positive modulator and varenicline), and none of them selected trials based on the specific treatment target for the agent added to the antipsychotic drug.…”

Managing treatment resistance in schizophrenia: A joint study in Hong Kong and Singapore

“…A meta-analysis that studied the efficacy of 42 pharmacologic cotreatment strategies added to antipsychotic monotherapy in schizophrenia found significant effect sizes favoring the addition of mood stabilizers, such as lithium and lamotrigine ( 15 ). However, the addition of mood stabilizers was ultimately not recommended as the evidence was generally informed by small, short-term trials with poorly reported data ( 15 , 30 , 31 ).…”

Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments

“……”

Efficacy of 42 Pharmacologic Cotreatment Strategies Added to Antipsychotic Monotherapy in Schizophrenia

“…Of 3397 search engine hits, 29 meta-analyses were included, creating a total of 381 meta-analyzed trials and 19 321 study participants and providing meta-analytic data for antipsychotic drug treatments combined with 42 different psychotropic medications. Among these combinations, 37 were of any antipsychotic drug (not excluding clozapine) with a second psychotropic medication and 5 were specifically of combinations with clozapine (eFigure 1 in the Supplement). All included meta-analyses designated the primary outcome as total psychopathology except for 2 (glutamate positive modulator and varenicline), and none of them selected trials based on the specific treatment target for the agent added to the antipsychotic drug.…”

Managing treatment resistance in schizophrenia: A joint study in Hong Kong and Singapore

“…A meta-analysis that studied the efficacy of 42 pharmacologic cotreatment strategies added to antipsychotic monotherapy in schizophrenia found significant effect sizes favoring the addition of mood stabilizers, such as lithium and lamotrigine ( 15 ). However, the addition of mood stabilizers was ultimately not recommended as the evidence was generally informed by small, short-term trials with poorly reported data ( 15 , 30 , 31 ).…”

Current approaches to treatments for schizophrenia spectrum disorders, part I: an overview and medical treatments

“……”

Efficacy of 42 Pharmacologic Cotreatment Strategies Added to Antipsychotic Monotherapy in Schizophrenia

“…Of 3397 search engine hits, 29 meta-analyses were included, creating a total of 381 meta-analyzed trials and 19 321 study participants and providing meta-analytic data for antipsychotic drug treatments combined with 42 different psychotropic medications. Among these combinations, 37 were of any antipsychotic drug (not excluding clozapine) with a second psychotropic medication and 5 were specifically of combinations with clozapine (eFigure 1 in the Supplement). All included meta-analyses designated the primary outcome as total psychopathology except for 2 (glutamate positive modulator and varenicline), and none of them selected trials based on the specific treatment target for the agent added to the antipsychotic drug.…”

Managing treatment resistance in schizophrenia: A joint study in Hong Kong and Singapore

“…A meta-analysis that studied the efficacy of 42 pharmacologic cotreatment strategies added to antipsychotic monotherapy in schizophrenia found significant effect sizes favoring the addition of mood stabilizers, such as lithium and lamotrigine ( 15 ). However, the addition of mood stabilizers was ultimately not recommended as the evidence was generally informed by small, short-term trials with poorly reported data ( 15 , 30 , 31 ).…”