Lamotrigine decreases MRP8 and IL-7 in rat models of intractable epilepsy secondary to focal cortical dysplasia

Wei, Jianping; Nie, Qingmei; Li, Feng

doi:10.3892/etm.2016.3806

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…This reduces the in vivo expression levels of IL-7. [54] This means that IL-7 is an essential biomarker in focal epilepsy, which indicates that inflammation may have a vital function for focal epilepsy. Reducing IL-7 using drugs may help treat focal epilepsy.…”

Section: Causal Link Between Regulatory Cytokines and Epilepsymentioning

confidence: 99%

Unraveling the links between circulating bioactive factors and epilepsy: A bidirectional Mendelian randomization study

Wang,

Ma,

Liu

et al. 2024

Medicine

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Epidemiological research has shown that a variety of circulating bioactive factors are associated with epilepsy, including macrophage colony-stimulating factor, interleukin-1β, and tumor necrosis factor-α. To further investigate the associations between epilepsy and 41 inflammatory cytokines, this Mendelian randomization was performed. This study presents genome-wide association study summary data on 41 inflammatory cytokines and epilepsy. Epilepsy incorporates generalized and focal epilepsy. A two-sample Mendelian randomization method was used. In order to analyze causal relationships between exposures and outcomes, the inverse variance-weighted method was mainly used. The findings suggested that increased levels of interleukin-1 receptor antagonists and interleukin-5 may be significantly associated with increased risks of focal epilepsy (beta: 0.080, P = .043; beta: 0.083, P = .015). In addition, regulated upon activation normal T cell expressed and secreted factor and Macrophage colony-stimulating factor may be significantly associated with generalized epilepsy (beta: 0.110, P = .042; beta: –0.114, P = .024). Furthermore, inflammatory cytokines such as interleukin-10, interleukin-1β, interleukin-1Ra, interleukin-7, tumor necrosis factor-α, and interferon-γ may be identified as the result of focal epilepsy (beta: 0.152, P = .031; beta: 0.214, P = .037; beta: 0.214, P = .047; beta: 0.222, P = .031; beta: 0.224, P = .025; beta: 0.161, P = .018). This study suggests that interleukin-5 and interleukin-1 receptor antagonists are potentially correlated factors with focal epilepsy etiology, macrophage colony-stimulating factor and regulated upon activation normal T cell expressed and secreted factor are potentially correlated factors with generalized epilepsy etiology, while several inflammatory cytokines possibly contribute to focal epilepsy development downstream.

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Section: Causal Link Between Regulatory Cytokines and Epilepsymentioning

confidence: 99%