Lamotrigine-associated hemophagocytic lymphohistiocytosis

Hancock, Christie; Galvez, Angel G.

doi:10.1182/blood-2018-11-885509

Cited by 7 publications

(12 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Past medical history appeared in 8 patients, 8,9,15,17–20,22 and concomitant medication use was a factor in 12 patients 8–11,16–22 …”

Section: Resultsmentioning

confidence: 99%

“…Lamotrigine was immediately discontinued in 16 patients, continued to be used in one patient and switched to lacosamide and zonisamide in 2 patients 8,12 . In addition, 14 patients received steroid therapy, 8–10,13–22 7 patients received etoposide therapy, 8–10,13‐15,19 6 patients received antibiotics, 9,11,14,16,20 5 patients received immunoglobulin therapy, 14,17,18,20,22 2 patients received cyclosporine therapy, 16,22 and 1 patient received lenograstim 16 . One patient underwent intermittent dialysis and extracorporeal membrane oxygenation (ECMO) 10,14 .…”

Section: Resultsmentioning

confidence: 99%

“…A total of 17 patients (12 men and 5 women) from 15 studies were included (Table 2). [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] The median age of these patients was 29 years old (range 4-47), of whom 12 patients were from the United States, and one patient was from each of the following countries: the Netherlands, Japan, Turkey, Chile and China. Lamotrigine was mainly used to treat 11 patients with epilepsy, 8,9,12,13,17,18,[20][21][22] 2 patients with depression and bipolar disorder 10,[14][15][16] and one patient with depersonalization-derealization disorder as a mood stabilizer.…”

Section: Clinical Informationmentioning

confidence: 99%

“…[8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] The median age of these patients was 29 years old (range 4-47), of whom 12 patients were from the United States, and one patient was from each of the following countries: the Netherlands, Japan, Turkey, Chile and China. Lamotrigine was mainly used to treat 11 patients with epilepsy, 8,9,12,13,17,18,[20][21][22] 2 patients with depression and bipolar disorder 10,[14][15][16] and one patient with depersonalization-derealization disorder as a mood stabilizer. 11,19 Past medical history appeared in 8 patients, 8,9,15,[17][18][19][20]22 and concomitant medication use was a factor in 12 patients.…”

Section: Clinical Informationmentioning

confidence: 99%

See 3 more Smart Citations

Analysis of the clinical characteristics of lamotrigine‐induced haemophagocytic lymphohistiocytosis

Wang

Fan

et al. 2022

Clinical Pharmacy Therapeu

View full text Add to dashboard Cite

Haemophagocytic lymphohistiocytosis (HLH), also known as haemophagocytic syndrome (HPS), is an immune dysregulation disease.HLH can be familial and occur most often in infants but can occur at any age. HLH is characterized by an unremitting activation of CD8+ T cells and macrophages. 1 Clinical features can include fever and rash, splenomegaly, hepatitis, cytopenia, elevated triglyceride levels or low fibrinogen levels, hyperferritinaemia, haemophagocytosis, decreased or absent natural killer cell activity and elevated CD25 blood levels. 2 The usual causes are infections, malignancy or rheumatological conditions, while drugs cause a small number of cases of HLH. 3 If untreated, it causes organ damage, particularly in the liver, bone marrow and, presumably, the central nervous system (CNS); the median survival without treatment is estimated to be less than 2 months. 4 Lamotrigine was marketed in 1994 and was approved for the treatment of focal (partial) seizures, primary generalized tonicclonic seizures and generalized seizures of Lennox-Gastaut syndrome in both children and adults and for maintenance treatment in adults with bipolar disorder. 5 Lamotrigine is available as an oral tablet, an orally disintegrating tablet (ODT), a chewable tablet (CD) and

show abstract

“…Past medical history appeared in 8 patients, 8,9,15,17–20,22 and concomitant medication use was a factor in 12 patients 8–11,16–22 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Clinical Informationmentioning

confidence: 99%

Section: Clinical Informationmentioning

confidence: 99%

See 2 more Smart Citations

Analysis of the clinical characteristics of lamotrigine‐induced haemophagocytic lymphohistiocytosis

Wang

Fan

et al. 2022

Clinical Pharmacy Therapeu

View full text Add to dashboard Cite

show abstract

“…Reviewing the literature, it is evident that lamotrigine has been associated with iatrogenic/treatment associated HLH (Rx-HLH), although very rarely. To our knowledge, less than 10 cases were reported worldwide 17–23…”

Section: Discussionmentioning

confidence: 99%

Lamotrigine-associated haemophagocytic lymphohistiocytosis (HLH) confounded with underlying rheumatoid arthritis

et al. 2022

View full text Add to dashboard Cite

Haemophagocytic lymphohistiocytosis (HLH) is one of the rare haematological syndromes more commonly reported in infants/children than adults. This disease is known for its aggressive dysregulated immune response affecting the host rapidly, causing multiorgan dysfunction and thus carries a high mortality. The disease still remains cryptic in this current decade despite all the developments in the ever-evolving field of haematology. Due to its rare occurrence and being more frequent in infants and the paediatric population, the literature lacks enough data to standardise therapies. Such events in adults and the elderly are invariably related to an underlying insult such as infections, other autoimmune or rheumatological diseases or drugs. We describe an interesting case of a middle-aged Caucasian woman who presented with fever, pancytopenia and hepatitis, who was eventually diagnosed with HLH just in time to receive the life-saving specific treatment as per available guidelines.

show abstract

Lamotrigine

2019

Reactions Weekly

View full text Add to dashboard Cite

Lamotrigine-associated hemophagocytic lymphohistiocytosis

Cited by 7 publications

References 0 publications

Analysis of the clinical characteristics of lamotrigine‐induced haemophagocytic lymphohistiocytosis

Analysis of the clinical characteristics of lamotrigine‐induced haemophagocytic lymphohistiocytosis

Lamotrigine-associated haemophagocytic lymphohistiocytosis (HLH) confounded with underlying rheumatoid arthritis

Lamotrigine

Contact Info

Product

Resources

About