LAMMER kinase homolog, Lkh1, is involved in oxidative-stress response of fission yeast

High sucrose consumption promotes obesity whereas its low consumption induces oxidative stress in Drosophila melanogaster

“…Recently, it was found that both SOD isoforms are also regulated by LAMMER kinase homolog Doa (James et al, 2009), a dual specificity kinase, in Drosophila. This kinase was found to be involved in oxidative stress response in fission yeast, Schizosaccharomyces pombe (Park et al, 2003), and in human HeLa and MCF-7 human cell lines (James et al, 2009). It was shown that Clk2, Doa homolog in mice, is regulated by insulin (Rodgers et al, 2010), while yeast homolog Kns1p is under TOR signaling (Lee et al, 2012).…”

Oxidative stress response pathways: Fission yeast as archetype

“…In response to elevated HP levels Sty1 not only coordinates stress-mediated changes at the transcriptional level (Chen et al, 2008), but it also regulates gene expression at the posttranscriptional level through the direct or indirect control of RBP and PK activities (Park et al, 2003;Rodríguez-Gabriel & Russell, 2008). Specifically upon intermediate oxidative stress, the Csx1 RBP directly binds and stabilizes mRNAs of several genes that are under the transcriptional control of Atf1 (e.g.…”

“…In addition to its diverse physiological roles, the single fission yeast LK, namely Lkh1/Kic1 (Kim et al, 2001), phosphorylates Csx1 and, thus, plays an essential role in the stress-induced posttranscriptional regulation of gene expression (Kang et al, 2007). Lkh1-mediated phosphorylation of Csx1 results in increased stability of the atf1 transcript and induction of diverse stress-defense genes, including sod1 and ctt1/cta1 (James et al, 2009;Park et al, 2003). The stress-related activity of Lkh1 is presumably regulated through the Sty1 pathway (Figure 4) (Kang et al, 2007).…”

The LAMMER Kinase Homolog, Lkh1, Regulates Tup Transcriptional Repressors through Phosphorylation in Schizosaccharomyces pombe

“…Although a cellular function for LAMMER kinase in fungi has not yet been described, the lkh1 deletion mutant of Schizosaccharomyces pombe reveals various phenotypes, including abnormality in cell division (3, 18); flocculation in liquid medium and filamentous and adhesive growth on agar (3); and sensitivity to oxidative stress (19, 20). Recently, we found that phosphorylation by Lkh1 is required for the activation of Csx1, which protects mRNAs encoding the transcription factor, Atf1, from exonuclease-mediated decay under oxidative conditions (20).…”