Lamivudine and interferon-alpha combination treatment of childhood patients with chronic hepatitis B infection

Abstract

When the combination of large dosage interferon-alpha 2b and lamivudine therapy in children was compared at the end of therapy and 6 months after therapy, normalization of alanine aminotransferase and the clearances of hepatitis B e antigen and hepatitis B surface antigen in both groups were directly proportional to the duration of treatment. However, the higher complete response rate at 12 months of combination therapy was not statistically different from that at 6 months.

Steroid resistant nephrotic syndrome in a child with chronic hepatitis B infection

“…8,9 The present case highlights the possibility of hepatitis B associated MN in children presenting with nephrotic syndrome and the possible harm by initiating steroids without confirming HBsAg status. It is recommended that hepatitis B serology should be part of the initial screen in all children presenting with nephrotic syndrome, especially those from endemic areas where hepatitis B is prevalent.…”

Treatment of children with HBeAg-positive chronic hepatitis B: A systematic review and meta-analysis

“…1 highlights the articles' inclusion process. Twenty studies (1112 cases) were eligible; 9 for IFN␣ monotherapy [12][13][14][15][16][17][18][19][20], 6 for combined IFN plus LMV [21][22][23][24][25][26], 2 for IFN␣ plus immune modulators [27,28], 2 for IFN␣ plus prednisone [18,29], 1 for hepatitis B vaccine [30], and 1 for vitamin E [31], (Ref. [18] was used for 2 regimens).…”

“…Several studies had an open label design [12][13][14][15][16]25,26], while the others were randomized controlled studies, where the control group could be: no treatment [17][18][19][20][29][30][31], another therapeutic regimen [22,24,27,28], different doses of the same drug [23], or different durations of treatment [21].…”

4. Austrian Consensus-Statement for Diagnosis and Therapy of Hepatitis B 2009

“…Bei 24 % der Patienten kommt es im Laufe eines Jahres zur Resistenzbildung (YMDD-Mutation), die nach 2-jähriger Behandlung bis zu bis zu 59% ansteigt. Kombinationsbehandlungen oder sequenzielle Behandlungen von Lamivudin und Interferon verbessern möglicherweise das Therapieergebnis, doch größere kontrollierte Studien mit diesen Varianten fehlen derzeit [1,[136][137][138][139][140][141][142].…”