Lamins of the sea lamprey (Petromyzon marinus) and the evolution of the vertebrate lamin protein family

Schilf, Paul; Peter, Annette; Hurek, Thomas; Stick, Reimer

doi:10.1016/j.ejcb.2014.06.004

Cited by 10 publications

(11 citation statements)

References 69 publications

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“…2). 21 The presence of an additional exon with conserved lamin A-specific sequence features in the A-lamins of both chondrichthyan species further indicates that the lamin A gene had already evolved with the emergence of the Chondrichthyes. The exonintron pattern of vertebrate lamin genes is highly conserved.…”

Section: Vertebrate Lamin Proteinsmentioning

confidence: 99%

“…20 Previous analyses of the lamprey (Petromyzon marinus), a member of the Agnatha, revealed that the lamprey genome encodes 3 functional lamin genes. 21 One of these genes exhibits the features typical for a teleost/tetrapod LIII gene while the other 2 lack features that would allow assignment of orthology to teleost/tetrapod lamin genes. 21 RNA-seq data of the hagfish, Eptatretus cirrhatus, a member of the sister group of the lampreys allowed us to assemble 3 complete lamin transcripts (Supplementary sequence information).…”

Section: Vertebrate Lamin Proteinsmentioning

confidence: 99%

“…21 One of these genes exhibits the features typical for a teleost/tetrapod LIII gene while the other 2 lack features that would allow assignment of orthology to teleost/tetrapod lamin genes. 21 RNA-seq data of the hagfish, Eptatretus cirrhatus, a member of the sister group of the lampreys allowed us to assemble 3 complete lamin transcripts (Supplementary sequence information). The 3 hagfish lamins, LmnI, LmnII, and LIII resemble those of the lamprey.…”

Section: Vertebrate Lamin Proteinsmentioning

confidence: 99%

“…These data support our previous findings that lamin LIII is present in both, agnathans and gnathostomes, while orthology of the other 2 agnathan lamins to one of the gnathostome lamin sub-types cannot be assigned. 21 Lamin LmnI of both the lamprey and the hagfish lacks a CaaX-motif. Moreover, also in the hagfish there is no evidence for the presence of an A-type lamin.…”

Section: Vertebrate Lamin Proteinsmentioning

confidence: 99%

“…(ii) The lamprey LIII gene as well as the LIII genes of the teleosts/tetrapods encode 2 alternatively spliced CaaX-encoding exons. 18,19,21 The relative order of these 2 exons is highly conserved, i.e. the LIIIb-CaaX exon, which encodes additional membrane targeting motifs, is always located upstream of the LIIIa-CaaX exon.…”

Section: Vertebrate Lamin Proteinsmentioning

confidence: 99%

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Evolutionary changes in lamin expression in the vertebrate lineage

Stick

Peter

2017

Nucleus

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The nuclear lamina is involved in fundamental nuclear functions and provides mechanical stability to the nucleus. Lamin filaments form a meshwork closely apposed to the inner nuclear membrane and a small fraction of lamins exist in the nuclear interior. Mutations in lamin genes cause severe hereditary diseases, the laminopathies. During vertebrate evolution the lamin protein family has expanded. While most vertebrate genomes contain 4 lamin genes, encoding the lamins A, B1, B2, and LIII, the majority of non-vertebrate genomes harbor only a single lamin gene. We have collected lamin gene and cDNA sequence information for representatives of the major vertebrate lineages. With the help of RNA-seq data we have determined relative lamin expression levels for representative tissues for species of 9 different gnathostome lineages. Here we report that the level of lamin A expression is low in cartilaginous fishes and ancient fishes and increases toward the mammals. Lamin B1 expression shows an inverse tendency to that of lamin A. Possible implications for the change in the lamin A to B ratio is discussed in the light of its role in nuclear mechanics.

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Section: Vertebrate Lamin Proteinsmentioning

confidence: 99%