Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction

Nishimune, Hiroshi; Valdez, Gregorio; Jarad, George; Moulson, Casey L.; Müller, Ulrich; Miner, Jeffrey H.; Sanes, Joshua R.

doi:10.1083/jcb.200805095

Cited by 120 publications

(187 citation statements)

References 80 publications

Supporting

Mentioning

183

Contrasting

Order By: Relevance

“…Mice with a genetic ablation of 3-and 6-integrins, die too early to study the long-term functions of integrins in skeletal muscle maintenance (GeorgesLabouesse et al, 1996;Kreidberg et al, 1996). The distribution of laminin 5, which is the main ligand for 3-integrin, suggests a possible function in maturation of the muscle fibre and of the NMJ, since its initial expression throughout the basal lamina of developing myotubes becomes restricted to the NMJ in the first 3 weeks following birth (Nishimune et al, 2008). This is also consistent with 3-integrin expression being concentrated at the presynaptic NMJ (Martin et al, 1996).…”

Section: Developmental Expression Of Integrins In Skeletal Musclesupporting

confidence: 55%

Integrins in the Development and Pathology of Skeletal Muscle

Brown¹,

Mueller²,

Conti³

2012

Neuromuscular Disorders

View full text Add to dashboard Cite

Section: Developmental Expression Of Integrins In Skeletal Musclesupporting

confidence: 55%

Integrins in the Development and Pathology of Skeletal Muscle

Brown¹,

Mueller²,

Conti³

2012

Neuromuscular Disorders

View full text Add to dashboard Cite

“…Laminins 4, 9, and 11 that share the same β2 and γ1 but differ in their α chains (α2, α4, and α5, respectively) are localized to the synaptic cleft of mammalian NMJs (13,14). Knockout experiments in mice show that α4 and α5 play roles in NMJ development and maturation (15,16). Laminins are also required for the aggregation of dystroglycan complexes by providing mechanical links for postsynaptic organization (17).…”

mentioning

confidence: 99%

Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions

Tsai

Wang

Kao

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Retrograde signals induced by synaptic activities are derived from postsynaptic cells to potentiate presynaptic properties, such as cytoskeletal dynamics, gene expression, and synaptic growth. However, it is not known whether activity-dependent retrograde signals can also depotentiate synaptic properties. Here we report that laminin A (LanA) functions as a retrograde signal to suppress synapse growth at Drosophila neuromuscular junctions (NMJs). The presynaptic integrin pathway consists of the integrin subunit βν and focal adhesion kinase 56 (Fak56), both of which are required to suppress crawling activity-dependent NMJ growth. LanA protein is localized in the synaptic cleft and only muscle-derived LanA is functional in modulating NMJ growth. The LanA level at NMJs is inversely correlated with NMJ size and regulated by larval crawling activity, synapse excitability, postsynaptic response, and anterograde Wnt/ Wingless signaling, all of which modulate NMJ growth through LanA and βν. Our data indicate that synaptic activities down-regulate levels of the retrograde signal LanA to promote NMJ growth.structural plasticity | BMP/Gbb | GluR | para | eag Sh

show abstract

“…A complete review of this is outside the scope of this article but a few examples will be mentioned. For example laminin α4 is important for the alignment of pre and post synaptic nerve endings (Patton et al 2001) whilst laminin α5 is required for postsynaptic maturation (Nishimune et al 2008). Lamb2 mutations result in presynaptic defects (Noakes et al 1995a) leading to failure to thrive in Lamb2 -/-mice, a model for Pierson syndrome.…”

mentioning

confidence: 99%

Basement membranes and human disease

2009

View full text Add to dashboard Cite

Abbreviations BM: basement membrane, NMJ neuromuscular junction, DEJ dermo epidermal junction, SJS Schwartz Jampel syndrome, DDSH Dyssegmental dysplasia silverman handmaker type, EB epidermolysis bullosa, GBM glomerular basement membrane 1 AbstractIn 1990 the role of basement membranes in human disease was established by the identification of COL4A5 mutations in Alport's syndrome. Since then the number of diseases caused by mutations in basement membrane components has steadily increased as has our understanding of the roles of basement membranes in organ development and function. However, many questions remain as to the molecular and cellular consequences of these mutations and how they lead to the observed disease phenotypes. Despite this, exciting progress has recently been made with potential treatment options for some of these so far incurable diseases.

show abstract

Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction

Cited by 120 publications

References 80 publications

Integrins in the Development and Pathology of Skeletal Muscle

Integrins in the Development and Pathology of Skeletal Muscle

Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions

Basement membranes and human disease

Contact Info

Product

Resources

About