Laminin α5β2γ1 promotes uterine stromal cells' mesenchymal-epithelial transition during decidualization
Peng-Chao Wang,
Tao Fu,
Juan Xie
et al.
Abstract:Decidualization is critical to pregnancy in primates and rodents. Endometrial stromal cells undergo the mesenchymal-epithelial transition to transform into decidual stromal cells to provide nutrition and support vascularization during decidualization. Laminins, as the main component of the epithelial basement membrane, regulate cellular adhesion, growth, migration, and differentiation. Our previous study showed that laminin α5β2γ1 strongly expressed in mouse decidua. However, the regulation and function of lam… Show more
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