Laminar flow-assisted synthesis of amorphous ZIF-8-based nano-motor with enhanced transmigration for photothermal cancer therapy

Kaang, Byung Kwon; Ha, Laura; Joo, Jeong-Un; Kim, Dong-Pyo

doi:10.1039/d2nr02501a

Cited by 4 publications

(4 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These components are currently being explored for their potential applications in targeted drug delivery and bio-precise sensing. [93,94] Drug-carrying micro-nanomotors can achieve excellent tumor penetration performance under their autonomous motion, thereby enhancing the therapeutic effects of drugs. Previously, the development of nanomotors has been hindered by limitations in the penetration depth of the nanoparticlemodified motor bases, which are primarily based on NIR-I light absorption.…”

Section: Dopamine-based Hydrogelmentioning

confidence: 99%

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Chen

Yue

Yang

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

The application of nanomaterials in healthcare has emerged as a promising strategy due to their unique structural diversity, surface properties, and compositional diversity. In particular, they have found a significant role in improving drug delivery and inhibiting the growth and metastasis of tumor cells. Moreover, recent studies have highlighted their potential in modulating the tumor microenvironment (TME) and enhancing the activity of immune cells to improve tumor therapy efficacy. Various types of nanomaterials are currently utilized as drug carriers, immunosuppressants, immune activators, immunoassay reagents, and more for tumor immunotherapy. Necessarily, nanomaterials used for tumor immunotherapy can be grouped into two categories: organic and inorganic nanomaterials. Though both have shown the ability to achieve the purpose of tumor immunotherapy, their composition and structural properties result in differences in their mechanisms and modes of action. Organic nanomaterials can be further divided into organic polymers, cell membranes, nanoemulsion‐modified, and hydrogel forms. At the same time, inorganic nanomaterials can be broadly classified as nonmetallic and metallic nanomaterials. The current review aims to explore the mechanisms of action of these different types of nanomaterials and their prospects for promoting tumor immunotherapy.This article is protected by copyright. All rights reserved

show abstract

Section: Dopamine-based Hydrogelmentioning

confidence: 99%

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Chen

Yue

Yang

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…The Pdop core flow acted as a synthetic barrier, with the mass of reagents from the sheath flow being able to control the amount of transfer and the mass transfer of reagents in the sheath flow, effectively coiling the enzyme into a self-assembled, amorphous ZIF-8 shell, with quenching of core–shell products, and membrane filters were necessary to remove unreacted reagents in a timely manner. 57 Zhao et al first synthesised DNAzyme-loaded nanoparticles to mimic viral nucleocoats containing genomes. Zn 2+ -dependent DNAzyme (named TD) was encapsulated into ZIF-90 nanoparticles (named Z@TD) using a one-step synthesis procedure.…”

Section: Chemical Synthesis and Preparation Of Zn-mofsmentioning

confidence: 99%

Recent advances in Zn-MOFs and their derivatives for cancer therapeutic applications

Li,

Zhang,

et al. 2023

Mater. Adv.

View full text Add to dashboard Cite

show abstract

“…The nanomotor offered high transmigration which had a powerful effect on BC cell ablation via PTT. [ 172 ] Realizing the intelligent controlled release of nanocarriers is also an index to test MOF materials as better drug carriers. These studies have shown that MOFs present advantages in enhancing drug therapy, whether in drug loading or in the dynamic therapy of nanomaterials.…”

Section: Nanomaterials For Bc Therapymentioning

confidence: 99%

Designing Intelligent Nanomaterials to Achieve Highly Sensitive Diagnoses and Multimodality Therapy of Bladder Cancer

Chen

et al. 2023

Small Methods

View full text Add to dashboard Cite

Bladder cancer (BC) is among the most common malignant tumors of the genitourinary system worldwide. In recent years, the rate of BC incidence has increased, and the recurrence rate is high, resulting in poor quality of life for patients. Therefore, how to develop an effective method to achieve synchronous precise diagnoses and BC therapies is a difficult problem to solve clinically. Previous reports usually focus on the role of nanomaterials as drug delivery carriers, while a summary of the functional design and application of nanomaterials is lacking. Summarizing the application of functional nanomaterials in high‐sensitivity diagnosis and multimodality therapy of BC is urgently needed. This review summarizes the application of nanotechnology in BC diagnosis, including the application of nanotechnology in the sensoring of BC biomarkers and their role in monitoring BC. In addition, conventional and combination therapies strategy in potential BC therapy are analyzed. Moreover, different kinds of nanomaterials in BC multimodal therapy according to pathological features of BC are also outlined. The goal of this review is to present an overview of the application of nanomaterials in the theranostics of BC to provide guidance for the application of functional nanomaterials to precisely diagnose and treat BC.

show abstract

Laminar flow-assisted synthesis of amorphous ZIF-8-based nano-motor with enhanced transmigration for photothermal cancer therapy

Abstract: Enzyme-powered nano-motors have promising applications in various fields owing to their biocompatibility. However, enzymes can undergo denaturation by harsh conditions. Here, we report a flow-assisted synthesis of enzyme-based amorphous ZIF-8...

Cited by 4 publications

References 42 publications

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Four Ounces Can Move a Thousand Pounds: The Enormous Value of Nanomaterials in Tumor Immunotherapy

Recent advances in Zn-MOFs and their derivatives for cancer therapeutic applications

Designing Intelligent Nanomaterials to Achieve Highly Sensitive Diagnoses and Multimodality Therapy of Bladder Cancer

Contact Info

Product

Resources

About