Laminar distributions of interneurons in the main olfactory bulb of the adult hamster

Schneider, Stephen P.; Macrides, Foteos

doi:10.1016/0361-9230(78)90063-1

Cited by 193 publications

(165 citation statements)

References 17 publications

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“…The interneurons resembled the VG and parvalbumin-IR multipolar interneurons described in the hamster and rat (Schneider and Macrides, 1978;Kosaka et al, 1994). As with the hamster and rat interneurons, two poles of the cell body typically gave rise to two-to-four processes, which were gradually tapering, suggesting that they were dendrites.…”

Section: Morphologymentioning

confidence: 55%

“…Biocytin staining shows that the mouse interneurons resemble the VG and parvalbumin-IR multipolar interneurons described in the hamster and rat using other staining methods (Schneider and Macrides, 1978;Kosaka et al, 1994). Like many of the hamster and rat interneurons, the mouse interneurons do not appear to bear axons.…”

Section: Discussionmentioning

confidence: 76%

“…In the rat and hamster, which have been most thoroughly studied, it nevertheless contains significant numbers of interneurons (Schneider and Macrides, 1978;Kosaka et al, 1994), tufted cells of several types (Macrides and Schneider, 1982), and astrocytes (Bailey and Shipley, 1993;Mirich et al, 2002). Electrophysiological recordings have shown that the responses of different M/T cell types to ON stimulation are correlated with the depth of the lateral dendrites in the EPL (Ezeh et al, 1993).…”

mentioning

confidence: 99%

“…Schneider and Macrides (1978) subsequently proposed that in the hamster EPL, Van Gehuchten (VG) cells interact with granule cell dendrites. More recently, multipolar neurons with morphological features of VG cells and SA cells have been identified in the rat EPL using staining methods for neuropeptides (Gall et al, 1986), NADPH diaphorase (Scott et al, 1987), and Ca 2ϩ -binding proteins (Briñón et al, 1992;Kosaka et al, 1994).…”

mentioning

confidence: 99%

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Properties of external plexiform layer interneurons in mouse olfactory bulb slices

et al. 2005

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Section: Morphologymentioning

confidence: 55%

Section: Discussionmentioning

confidence: 76%

mentioning

confidence: 99%

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confidence: 99%

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Properties of external plexiform layer interneurons in mouse olfactory bulb slices

et al. 2005

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“…A similar idea has also been proposed for the whole population of deep shortaxon cells (Schneider and Macrides, 1978), which are thought to provide pathways for disinhibition of mitral and tufted cells via inhibitory axosomatic and axodendritic synapses on GABAergic GCs (Macrides et al, 1985). Because deep GCs establish dendrodendritic synapses predominantly with the lateral dendrites of mitral cells, they might also directly modulate their oscillatory activity.…”

Section: Sites Of Production and Migration Rates Of Newborn Neurons Amentioning

confidence: 65%

Neonatal and Adult Neurogenesis Provide Two Distinct Populations of Newborn Neurons to the Mouse Olfactory Bulb

Lemasson¹

2005

J. Neurosci.

179

159

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In mammals, the olfactory bulb (OB) constitutes one of two regions of the postnatal brain with continuous neurogenesis throughout life. Despite intense explorations of neuronal replacement in the adult OB, little is known about the mechanisms that operate at earlier postnatal stages. This question is particularly pertinent, because the majority of local interneurons are born in the neonate, when olfaction controls vital functions. Here, we analyzed the recruitment of newborn cells to the granule cell (GC) layer (GCL) and found that the postnatal mouse OB is supplied with two spatiotemporally distinct populations of newborn interneurons.Early born [postnatal day 3 (P3) to P7] GCs constitute a threefold larger population compared with those generated later (P14 -P60), and some of them are produced locally within the OB itself. Newborn interneurons generated at P3-P7 were predominantly targeted to the external edge of the GCL, whereas newly generated cells were positioned deeper in older mice. Additionally, although ϳ50% of adult newborn cells were eliminated within a few weeks of reaching the OB, almost the entire population of early born GCs survived until adulthood. Importantly, early olfactory experience specifically modifies the number of newborn GCs in neonates but leaves unaltered the amount of neurons generated during adulthood. Together, these results demonstrate that early postnatal neurogenesis endows the neonate bulbar circuit with newborn GCs that differ morphologically and functionally from those produced in the adult.

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Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb: III. Structural features of calbindin D28K‐immunoreactive neurons

et al. 1998

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The present study analyzed three-dimensional structural features and synaptic contacts of morphologically and chemically identified calbindin D28K-immunoreactive neurons in the glomerular layer of the rat main olfactory bulb by means of combined confocal laser scanning light microscopy, high-voltage electron microscopy and electron microscopic serial section/three-dimensional reconstruction. Most of calbindin D28K-immunoreactive neurons were identified as the periglomerular cell type by combined high-voltage electron microscopic and confocal laser scanning light microscopic observations, and the minority were the short-axon cell type and others. The combined confocal laser scanning light microscopic and electron microscopic study revealed that the calbindin D28K-immunoreactive neurons exhibited unique synaptic contact patterns; they received asymmetrical synapses from presumed mitral/tufted dendrites and made conversely symmetrical synapses with them. About 30% of asymmetrical postsynaptic sites and about 40% of symmetrical presynaptic sites formed reciprocal pairs of synapses. Calbindin D28K-immunoreactive dendrites and somata also received synapses from GABA-like-immunoreactive profiles containing numerous pleomorphic, and a few dense-cored, vesicles. On the other hand, surprisingly, calbindin D28K-immunoreactive neurons had almost no synaptic contacts from olfactory nerve terminals. The present study clearly revealed that calbindin D28K-immunoreactive neurons are a type of periglomerular cell involving unique synaptic contacts that have not been reported so far, and thus indicated that so-called periglomerular cells should be heterogeneous in their synaptic connections as well as in their chemical and structural features.

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Laminar distributions of interneurons in the main olfactory bulb of the adult hamster

Cited by 193 publications

References 17 publications

Properties of external plexiform layer interneurons in mouse olfactory bulb slices

Properties of external plexiform layer interneurons in mouse olfactory bulb slices

Neonatal and Adult Neurogenesis Provide Two Distinct Populations of Newborn Neurons to the Mouse Olfactory Bulb

Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb: III. Structural features of calbindin D28K‐immunoreactive neurons

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