Lamina cribrosa depth according to the level of axial length in normal and glaucomatous eyes

Yun, Sung‐Cheol; Hahn, Ines; Sung, Kyung Rim; Yoon, Joo Young; Jeong, Daun; Chung, Ho Seok

doi:10.1007/s00417-015-3131-y

Cited by 14 publications

(10 citation statements)

References 26 publications

(24 reference statements)

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“…In addition, ONH and peripapillary structures could have different elasticity properties in myopic eyes and, therefore, respond differently to volume changes. 37,38 In the current study, we did not find any significant correlation among AL, ONH, and IOP changes, but the ability to assess this relationship is low due to the limited range of the AL included (21.8-25.4 mm). Intraocular pressure measurement is influenced by central corneal thickness (CCT); however, it has been reported recently that CCT does not change with intravitreal anti-VEGF injections.…”

Section: Discussioncontrasting

confidence: 63%

Optic Nerve Head Biomechanic and IOP Changes Before and After the Injection of Aflibercept for Neovascular Age-Related Macular Degeneration

Rebolleda

Puerto

Juan

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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A significant widening and deepening of the optic cup, BMO expansion, and prelaminar tissue thinning occurred following IAI for neovascular AMD. Eyes having greater optic disc cup deepening and prelaminar tissue condensation after IAI, associated with a lower IOP increase after injection, suggesting that ONH compliance might buffer the effect of additional intravitreal fluid injection on IOP values.

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Section: Discussioncontrasting

confidence: 63%

Optic Nerve Head Biomechanic and IOP Changes Before and After the Injection of Aflibercept for Neovascular Age-Related Macular Degeneration

Rebolleda

Puerto

Juan

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…Among the various morphological changes found in patients with glaucoma, posterior displacement of the LC is considered a key feature of glaucomatous optic nerve damage. Few studies have conducted detailed investigations of LC depth in healthy myopic eyes 39 . In a study performed on a Korean population, Yun et al .…”

Section: Discussionmentioning

confidence: 99%

Bruch’s membrane opening enlargement and its implication on the myopic optic nerve head

Sung

Heo

et al. 2019

Sci Rep

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We examined the association between Bruch’s membrane opening (BMO) area and various ocular parameters and investigated the implication of BMO enlargement on the myopic optic nerve head. One hundred eighty-five myopic eyes were included in this cross-sectional study. Among the included eyes, 53 having axial lengths between 26 and 27 mm were further analyzed to investigate the association between BMO area and various ocular parameters. BMO area, BMO-minimum rim width (BMO-MRW), peripapillary choroidal thickness (pCT), width of β-parapapillary atrophy with and without Bruch’s membrane (PPA+BM and PPA−BM), and presence of lamina cribrosa (LC) defect were evaluated. We found that BMO area tended to increase with increasing axial length, but varied among the highly myopic eyes even though they had similar degrees of myopia. In the subgroup analysis of eyes with axial lengths between 26 and 27 mm, BMO area was highly variable and it significantly correlated with PPA−BM width and temporal-inferior, nasal-inferior, and nasal BMO-MRW and pCT. LC defects were more common in myopic eyes with enlarged BMO. A multivariate regression model revealed that higher intraocular pressure, enlarged BMO, and thinner BMO-MRW were associated with LC defects in highly myopic eyes. These findings should be considered when evaluating myopic eyes.

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“…According to previous normal data in which the LCD was evaluated depending on the mean axial length of the eyeball, the mean LCD was 578.2 ± 163.5 µm when the axial length fell in the range of 23 to 26 mm [15]. Even though the results of the present study could not be directly compared with these previous data, the LC of the muscle-dominant group was displaced more anteriorly than that of the fat-dominant group at baseline.…”

Section: Discussionmentioning

confidence: 99%

Effects of Orbital Decompression on Lamina Cribrosa Depth in Patients with Graves' Orbitopathy

Seo

Shin

Bae

et al. 2019

Korean J Ophthalmol

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PurposeWe sought to investigate the effects of Graves' orbitopathy (GO) and orbital decompression on lamina cribrosa depth (LCD) using spectral-domain optical coherence tomography.MethodsForty eyes that underwent orbital decompression to relieve compressive optic neuropathy or correct disfiguring exophthalmos in the context of GO were included. Subjects were imaged with spectral-domain optical coherence tomography before surgery and at 1 and 3 months after surgery, at which the examiner measured the LCD (distance from the anterior surface of the lamina cribrosa to the Bruch membrane opening line) and peripapillary retinal nerve fiber layer thickness. Subjects were divided into two groups—a muscle-dominant group composed of patients who had extraocular muscle enlargement on preoperative orbital computed tomography scan and a fat-dominant group composed of patients who did not show extraocular muscle enlargement on preoperative orbital computed tomography scan—and subgroup analysis was performed. Preoperative and postoperative intraocular pressure, exophthalmos, LCD, and retinal nerve fiber layer thickness were evaluated.ResultsAt baseline, LCD was remarkably shallower in the muscle-dominant group than in the fat-dominant group (95% confidence interval, p = 0.007). In the muscle-dominant group, LCD showed no definite change after surgery. However, the fat-dominant group showed temporary posterior displacement of the lamina cribrosa at 1-month postoperation that was reversed to baseline at 3 months postoperation (95% confidence interval, p < 0.01).ConclusionsThe lamina cribrosa was anteriorly displaced preoperatively, and its position was nearly unchanged after the surgery, especially in association with extraocular muscle enlargement. An enlarged extraocular muscle could reduce the pressure-relieving effect of orbital decompression around the scleral canal in patients with GO.

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Lamina cribrosa depth according to the level of axial length in normal and glaucomatous eyes

Abstract: LC depth may vary according to the level of AXL in glaucomatous eyes with a similar level of glaucoma severity, with the greatest LC depth found in eyes with long AXL. Those findings suggest that glaucomatous optic disc cupping would manifest differently according to the level of AXL.

Cited by 14 publications

References 26 publications

Optic Nerve Head Biomechanic and IOP Changes Before and After the Injection of Aflibercept for Neovascular Age-Related Macular Degeneration

Optic Nerve Head Biomechanic and IOP Changes Before and After the Injection of Aflibercept for Neovascular Age-Related Macular Degeneration

Bruch’s membrane opening enlargement and its implication on the myopic optic nerve head

Effects of Orbital Decompression on Lamina Cribrosa Depth in Patients with Graves' Orbitopathy

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