Lamellar slippage of bilayers in natural joints lubrication

Mreła, Aleksandra; Pawlak, Zenon

doi:10.15761/pmrr.1000175

Cited by 1 publication

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“…A surface-active phospholipid layer covers normal articular surfaces in a multi-bilayer structure [3]. The bilayers serve to integrate interfacial functions between surfaces and have been a subject of several inquiries due to its tribological features [5,10]. However, at sites of articular cartilage damage, the SAPL is absent, because a suitable substrate upon which this vital lipid layer can form does not exist [5,7].…”

Section: Figure 1 β2-glycoprotein I (β2-gpi) (Open Hockey Stick) Is Complexed To Negatively Charged Phospholipids (-Po4-) Resulting In Thmentioning

confidence: 99%

“…The pathological synovial fluid contains three times more phospholipids (PL), but the cartilage structure changes and its ability to lubricate, is remarkably poor. During normal functioning, the SAPL serves as a sacrificial perturbation bilayer, whereby it can improve by self-assembly mechanisms [10].…”

Section: Figure 1 β2-glycoprotein I (β2-gpi) (Open Hockey Stick) Is Complexed To Negatively Charged Phospholipids (-Po4-) Resulting In Thmentioning

confidence: 99%

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The effect of deactivated phospholipids on joints lubrication: Osteoarthritis and lubricating properties

Pawlak¹

2021

CMRR

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PLs bilayers coating the major synovial joints such as knees and hips as the lubricant are responsible for the lubrication of articular cartilage. Lamellar-repulsive effect has been considered as a lubrication mechanism but it is likely that lubricin and hyaluronan with PLs participate in the lubrication process. The molecules of lubricin and hyaluronan adsorbed by PLs have a supportive role and provide the efficient lubrication of synovial joints via the hydration mechanism (~ 80% water content). Lipid profiles of injured and healthy knees’ synovial fluids show significant differences. The phospholipid content in synovial fluid (SF) during joint inflammation, osteoarthritis is significantly higher (2 to 3 times) above the normal concentration of PL, and has a poor boundary-lubricating ability because of deactivated PL molecules. Deactivated PL molecule has no ability to form bilayers, lamellar phases, and liposomes.

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Section: Figure 1 β2-glycoprotein I (β2-gpi) (Open Hockey Stick) Is Complexed To Negatively Charged Phospholipids (-Po4-) Resulting In Thmentioning

confidence: 99%

Section: Figure 1 β2-glycoprotein I (β2-gpi) (Open Hockey Stick) Is Complexed To Negatively Charged Phospholipids (-Po4-) Resulting In Thmentioning

confidence: 99%

The effect of deactivated phospholipids on joints lubrication: Osteoarthritis and lubricating properties

Pawlak¹

2021

CMRR

View full text Add to dashboard Cite

show abstract

Lamellar slippage of bilayers in natural joints lubrication

Cited by 1 publication

References 0 publications

The effect of deactivated phospholipids on joints lubrication: Osteoarthritis and lubricating properties

The effect of deactivated phospholipids on joints lubrication: Osteoarthritis and lubricating properties

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