Lamellar slippage of bilayers—A hypothesis on low friction of natural joints

Pawlak, Zenon; Urbaniak, Wiesław; Hagner‐Derengowska, Magdalena; Hagner, Wojciech

doi:10.1116/1.4902805

Cited by 7 publications

(4 citation statements)

References 47 publications

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“…This protein can interact with the phospholipid membranes by electrostatic interactions and hydrophobic loops [44]. Binding β2-GP I to anionic charged phospholipid groups (-PO 4 − ) at a pH of 7.4 causes a change in the protein conformation [46][47][48]. The softening of the cartilage is the first phase of cartilage deterioration [45,49].…”

Section: Deactivation Of a Surface-active Phospholipid Bilayermentioning

confidence: 99%

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

et al. 2019

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Some solid lubricants are characterized by a layered structure with weak (van der Waals) inter-interlayer forces which allow for easy, low-strength shearing. Solid lubricants in natural lubrication are characterized by phospholipid bilayers in the articular joints and phospholipid lamellar phases in synovial fluid. The influence of the acid–base properties of the phospholipid bilayer on the wettability and properties of the surface have been explained by studying the interfacial tension of spherical lipid bilayers based on a model membrane. In this paper, we show that the phospholipid multi-bilayer can act as an effective solid lubricant in every aspect, ranging from a ‘corrosion inhibitor’ in the stomach to a load-bearing lubricant in bovine joints. We present evidence of the outstanding performance of phospholipids and argue that this is due to their chemical inertness and hydrophilic–hydrophobic structure, which makes them amphoteric and provides them with the ability to form lamellar structures that can facilitate functional sliding. Moreover, the friction coefficient can significantly change for a given phospholipid bilayer so it leads to a lamellar-repulsive mechanism under highly charged conditions. After this, it is quickly transformed to result in stable low-friction conditions.

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Section: Deactivation Of a Surface-active Phospholipid Bilayermentioning

confidence: 99%

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

et al. 2019

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“…Increased values of the coefficient of friction are interpreted by a decrease in the number of bilayers [2,6]. The implication of this condition was observed in osteoarthritis, where the increase in the coefficient of friction was associated with the gradual loss of surface amorphous layer, SAL [16,17]. Phospholipid lamellar phases and biomacromolecules in SF participate in the electrostatic repulsion of the surface during friction.…”

Section: Hydrophilic and Hydrophobic Character Cartilage Surfacementioning

confidence: 99%

“…Phospholipid lamellar phases and biomacromolecules in SF participate in the electrostatic repulsion of the surface during friction. Strongly hydrated lamellar PLs are expected to cover cartilage surfaces and participate in hydrophilic-lamellar lubrication [2, 16,17].…”

Section: Hydrophilic and Hydrophobic Character Cartilage Surfacementioning

confidence: 99%

Nanostructures of Phospholipids on Articular Cartilage Surface and their Functions

Pawlak¹,

Sójka²

2021

JCRR

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Phospholipids bilayers fulfill an important role in natural joint lamellar-repulsive lubrication mechanism. Low friction between surfaces coated with negatively charged the phospholipid headgroup (–PO4-) as being due to a hydration layer. Wettability of the cartilage surface depends on the number of PLs that act as a lubricant. The cartilage can be classified as a group of intelligent material, which in the wet state has a contact angle of ~0º, and the air-dry state has a contact angle of ~104º.

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“…In synovial joint organ systems, a surface active phospholipid layer (SAPL) covers normal articular surfaces in an oligolamellar structural formation [1,2,3,4,5]. The SAPL serves to integrate interfacial functions between juxtaposed surfaces and has been a subject of much inquiry due to its tribological features [6,7,8,9,10,11,12,13]. However, at sites of articular cartilage damage, the SAPL is deactivated, because a suitable substrate upon which a SAPL can form does not exist [1,6,7,14].…”

Section: Introductionmentioning

confidence: 99%

The Anomalies of Hyaluronan Structures in Presence of Surface Active Phospholipids—Molecular Mass Dependence

et al. 2018

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Abstract:Interactions between hyaluronan (A-) and phospholipids play a key role in many systems in the human body. One example is the articular cartilage system, where the synergistic effect of such interactions supports nanoscale lubrication. A molecular dynamics simulation has been performed to understand the process of formation of hydrogen bonds inside the hyaluronan network, both in the presence and absence of phospholipids. Additionally, the effect of the molecular mass of (A-) was analyzed. The main finding of this work is a robust demonstration of the optimal parameters (H-bond energy, molecular mass) influencing the facilitated lubrication mechanism of the articular cartilage system. Simulation results show that the presence of phospholipids has the greatest influence on hyaluronan at low molecular mass. We also show the specific sites of H-bonding between chains. Simulation results can help to understand how hyaluronan and phospholipids interact at several levels of articular cartilage system functioning.

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Lamellar slippage of bilayers—A hypothesis on low friction of natural joints

Cited by 7 publications

References 47 publications

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study

Nanostructures of Phospholipids on Articular Cartilage Surface and their Functions

The Anomalies of Hyaluronan Structures in Presence of Surface Active Phospholipids—Molecular Mass Dependence

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