Lambert-Eaton myasthenic syndrome in association with transitional cell carcinoma: a previously unrecognized association

Collins, Rónán; Connolly, Stuart; Burns, Matthew J.; Offiah, L; Grainger, Ronald G.; Walsh, J. B.

doi:10.1016/s0090-4295(98)00583-4

Cited by 16 publications

(7 citation statements)

References 23 publications

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“…LEMS is thought to have a paraneoplastic origin from small-cell carcinoma of the lung. Some rare case reports have chronicled the relationship between this condition and malignancies in the bladder, especially transitional cell carcinoma (4). Coexistence of MG and LEMS is very rare, but this presentation in our patient, who had a history of adenocarcinoma of the bladder, has not been previously reported.…”

Section: Discussionmentioning

confidence: 61%

“…RNS shows greater-than-100% incremental changes on high-rate stimulation. In most cases, a para-neoplastic origin from small-cell carcinoma of the lung is present (4,5). Conversely, oculobulbar symptoms, elevated anti-AChR antibody titers, and a positive edrophonium test are typical presentations of MG (5).…”

Section: Discussionmentioning

confidence: 99%

“…The syndrome is known to relate to a variety of malignancies, especially small-cell carcinoma of the lung. Rare case reports in the literature reported the relationship between LEMS and bladder and ureter can- cers, especially transitional cell carcinoma of the bladder (4). Considering the underlying cause of the condition, it has a very poor prognosis (4) Coexistence of both MG and LEMS is very rare.…”

Section: Introductionmentioning

confidence: 99%

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Rare Coexistence of Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome with Adenocarcinoma of the Bladder: A Case Report

Ashjazadeh

Dorche

Zareifar

et al. 2017

IMMINV

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Background: The presence of both myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS) in one patient is very rare. Here, we report the case of a patient with these coexisting conditions. Case Presentstion: An 82-year-old man with a history of adenocarcinoma of the bladder was referred to the neurology ward with diplopia, dysphagia, ptosis in the left eye, weakness in both lower extremities, and autonomic dysfunction. Coexistence of MG and LEMS was diagnosed according to clinical and para-clinical evaluations. Conclusion: Coexistence of MG and LEMS is very rare, but this presentation in a patient with a history of adenocarcinoma of the bladder has not been previously reported. We emphasize the importance of carefully evaluating patients with LEMS for any underlying malignancy.

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Rare Coexistence of Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome with Adenocarcinoma of the Bladder: A Case Report

Ashjazadeh

Dorche

Zareifar

et al. 2017

IMMINV

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“…Approximately 50-60% of patients have an underlying tumor, most commonly small cell lung carcinoma, although LEMS has also been reported in association with breast carcinoma, Hodgkin's lymphoma, renal cell carcinoma, adenocarcinomas, ovarian epithelial cell carcinoma and transitional cell carcinoma of the bladder [1][2][3][4]. Cancer-associated LEMS is a paraneoplastic disorder, in which antibodies to tumor antigens are presumed to crossreact with identical or similar antigens on neuronal tissue [5].…”

Section: Lambert-eaton Myasthenic Syndrome (Lems)mentioning

confidence: 99%

Autonomic dysfunction in Lambert-Eaton myasthenic syndrome

Waterman

2001

Clinical Autonomic Research

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Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder characterized by muscle weakness and autonomic dysfunction. Recent ex vivo and in vitro studies demonstrate that autoantibodies to the P/Q-subtype of voltage-gated calcium channel inhibit transmitter release from parasympathetic, sympathetic, and enteric neurons, a mechanism likely to underlie the widespread autonomic dysfunction in LEMS. This review summarizes clinical studies characterizing the autonomic symptoms and signs in LEMS and the effectiveness of treatment in alleviating these symptoms. Serological assays and in vitro pharmacologic and electrophysiologic studies are also discussed.

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“…Paraneoplastic syndromes are rare in bladder cancer, but previous case reports describe a wide range of metabolic, 1,2 dermatologic, 3 myopathic 4,5 and neurological disturbances. [6][7][8] Another documented paraneoplastic effect of transitional cell carcinoma (TCC) is the development of coagulopathy from the secretion of heparin-like anticoagulants. 9,10 We report a case of a patient presenting with this unusual phenomenon.…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic production of heparin-like anticoagulant in a patient with metastatic transitional cell carcinoma

Fahl

Poon

Badani

et al. 2013

CUAJ

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It has been reported that patients with bladder cancer have widely varying paraneoplastic consequences, including metabolic, dermatologic, myopathic and neurologic disturbances. We report a case of a 52-year-old man with advanced transitional cell carcinoma and liver metastases, who developed a severe coagulopathy following robotic radical cystoprostatectomy due to circulating heparin-like substances prior to onset of liver failure. Heparin-like anticoagulant production is a rare paraneoplastic effect documented in concert with transitional cell carcinoma, breast carcinoma and hematological malignancies.

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Lambert-Eaton myasthenic syndrome in association with transitional cell carcinoma: a previously unrecognized association

Cited by 16 publications

References 23 publications

Rare Coexistence of Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome with Adenocarcinoma of the Bladder: A Case Report

Rare Coexistence of Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome with Adenocarcinoma of the Bladder: A Case Report

Autonomic dysfunction in Lambert-Eaton myasthenic syndrome

Paraneoplastic production of heparin-like anticoagulant in a patient with metastatic transitional cell carcinoma

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