Lambert–Eaton myasthenic syndrome developing post‐diagnosis of small‐cell lung cancer

Dean, Samantha; McCracken, James Andrew; Kosmider, Suzanne; Herath, Dishan

doi:10.1111/imj.14128

Cited by 5 publications

(3 citation statements)

References 5 publications

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“…[ 4 ] The majority of patients with LEMS have previous or synchronic neurological symptoms with the diagnosis of the tumor. [ 5,6 ] In our case the LEMS is diagnosed and reported posterior to cancer resection. The presumptive of infraclinical diagnosis of LEMS in the pre-operative course that be revealed by the surgical stress can be discussed.…”

Section: Discussionmentioning

confidence: 68%

Lambert–Eaton myasthenic syndrome revealed after surgery of lung adenocarcinoma

Kabiri

Hammoumi

Sbitti

2021

Asian Cardiovasc Thorac Ann

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We report a very rare case of cT1N0M0 lung adenocarcinoma reveling Lambert-Eaton myasthenic syndrome (LEMS). A 69-year-old nonsmoking woman, with several comorbidities consulted for cough and dyspnea. Chest radiograph and CT scanning detected a left lower lobe mass; Needle biopsy confirmed differentiated adenocarcinoma; 18FDG-PET scan and Brain MRI eliminated metastatic disease dissemination. Our patient underwent a left lower lobectomy with mediastinal lymphadenectomy (pT1N0M0), no adjuvant chemotherapy was administrated. One month later patient present a muscle weakness in both lower limbs and fatigability followed by an inability to walk. The diagnosis of LEMS was made from the distinctive electromyogram (EMG) findings and a treatment with Amifampridine (3, 4-diaminopyridine phosphate [3, 4-DAP]) was prescribed with evident efficacy for symptoms.

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Section: Discussionmentioning

confidence: 68%

Lambert–Eaton myasthenic syndrome revealed after surgery of lung adenocarcinoma

Kabiri

Hammoumi

Sbitti

2021

Asian Cardiovasc Thorac Ann

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“…SCLC is often associated with LEMS. Other cancers connected to LEMS include non-small-cell and mixed lung carcinomas, prostate cancer, thymoma, and lymphoproliferative disorders [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Lambert-Eaton Myasthenia Syndrome Associated with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Literature

Abu-Tineh,

Alamin,

Aljaloudi

et al. 2023

Case Rep Oncol

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Introduction: Lambert-Eaton myasthenia syndrome (LEMS) is a rare autoimmune disorder characterized by autoantibodies targeting presynaptic neuromuscular junctions. It results in muscle weakness and autonomic dysfunction. LEMS can be idiopathic or associated with neoplastic diseases, often small-cell lung cancer. This case report describes a rare instance of paraneoplastic LEMS in a man with non-Hodgkin lymphoma. Case Presentation: A 57-year-old male with non-Hodgkin lymphoma presented with progressive muscle weakness, diminished reflexes, and autonomic symptoms. Diagnosis revealed LEMS with autoantibodies against voltage-gated calcium channels. Immunosuppressive therapy and lymphoma treatment led to significant improvement in his condition. Conclusion: This case highlights the rare occurrence of paraneoplastic LEMS in a patient with non-Hodgkin lymphoma. Recognition and timely management of LEMS alongside lymphoma treatment can lead to significant clinical improvement, emphasizing the need for increased awareness of such complex associations.

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“…The data were collected by medical staff/doctoral students with study/research grants from the European project on paraneoplastic neurological syndromes. On the basis of the criteria of the Paraneoplastic Neurologic Syndrome Euronetwork guidelines [ 5 ], PNS patients were identified according to clinical presentation with one of the following neurological syndromes: cerebellar degeneration [ 21 ]; encephalomyelitis, or limbic encephalitis [ 22 ]; polyneuropathy [ 23 ]; retinal degeneration [ 24 ]; motor neuron disease [ 25 ]; opsoclonus-myoclonus [ 26 ]; peripheral nervous disorders, including sensory neuro-/neuronopathy, dysautonomia and neuromyotony [ 27 ]; and Lambert-Eaton myasthenia syndrome, polymyositis and necrotizing myelopathy [ 28 , 29 ]. …”

Section: Methodsmentioning

confidence: 99%

Paraneoplastic Neurological Syndromes: Study of Prevalence in a Province of the Lombardy Region, Italy

Lorusso¹,

Precone²,

Ferrari³

et al. 2020

JCM

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Paraneoplastic neurological syndromes (PNSs) are a heterogeneous group of rare immune-mediated diseases associated with cancer. The aim of this study was to investigate the prevalence of PNSs in the province of Brescia. PNS prevalence was calculated using the Lombardy regional hospital admission records from 1998 to 2003. We used the website “Epidemiologic and Economic Atlas of Hospital Activities in Lombardy” and the “International Statistical Classification of Diseases and Related Health Problems”. In the province of Brescia, we found 54 cases of PNSs, 29 with subacute neuropathies, five with paraneoplastic cerebellar degeneration and 20 with encephalomyelitis. Peripheral nervous system diseases were the most frequent neurological disorders. In Lombardy, the number of PNS patients admitted was 322 (133 with encephalomyelitis, 21 with paraneoplastic cerebellar degeneration, 166 with polyneuropathies and two with optic degeneration). In Lombardy, the prevalence of PNSs was 25 in 100,000 hospital admissions and 5.92 in 100,000 for the Lombardy population. Our results show a discrete presence of PNS patients in the province of Brescia and in the Lombardy region as a whole.

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Lambert–Eaton myasthenic syndrome developing post‐diagnosis of small‐cell lung cancer

Cited by 5 publications

References 5 publications

Lambert–Eaton myasthenic syndrome revealed after surgery of lung adenocarcinoma

Lambert–Eaton myasthenic syndrome revealed after surgery of lung adenocarcinoma

A Rare Case of Lambert-Eaton Myasthenia Syndrome Associated with Non-Hodgkin’s Lymphoma: A Case Report and Review of the Literature

Paraneoplastic Neurological Syndromes: Study of Prevalence in a Province of the Lombardy Region, Italy

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