Lambdamycin, ein Antibioticum aus dem Stamm IMET 31118 von <i>Streptomyces glaucoachromogenes</i> PRAUSER II. Physikochemische Eigenschaften und Vergleich mit Chartreusin

Strauss, D.; Fleck, W. F.

doi:10.1002/jobm.19770170308

Cited by 2 publications

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References 9 publications

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“…cinon und ChartreusinPhysikalische und chemische Eigenschaften von Lambdamycin, seinem Aglykon Lambdamy-Lambdamycinon kann nach Hydrolyse auf ublichem Wege aus Lambdamycin gewonnen werden. des Chartreusin-Aglykons identisch(STRAUSS 1974). Gut loslich ist es dagegen in Dimethylformamid.…”

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Lambdamycin, ein Antibioticum aus dem Stamm IMET 31118 von Streptomyces glaucoachromogenes PRAUSER

Fleck

Strauss

Prauser

et al. 1976

J of Basic Microbiology

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Lambdamycin-producing strains were detected by means of the BIP test method. The isolation technique and the physicochemical and biological properties of lambdamycin, a n antibiotic produced by Streptomyces glaucoaehromogenea, are described. Lambdamycin is a yellow-green pigment of the chromoglycoside type. Digitalose and fucose are the sugar components. The physicochemical properties of lambdamycin resemble those of chartreusin. However, the known biological activity is different. The antibiotic can be isolated from culture filtrates and from the mycelium by extraction with lower aliphatic alcohols. It can be purified by gel filtration methods. Lambdamycin displays antimicrobial activity, particularly against grampositive bacteria. Strains which produce enzymes inactivating different commercial antibiotics are also inhibited. Moreover, lambdamycin shows antiviral activity, as well as cancerostatic and ergotropic action in vitro and i n vivo. The acute LD,, of lambdamycin in mice after 21 days was >125 mg/kg when administered intraperitoneally. Fiir eine gezielte Suche nach neuen Antibiotics mit potentiell cancerostatischerAktivitat gegen tierexperiinentelle Tumoren setzten wir eine Reihe von molekularbiologischen Screening-Modellen ein, die eine rationelle Vorauswahl von Inhibitoren des Nucleinsaure-Stoffwechsels und dessen Regulation gestatten (FLECK 1970).Uber Ergebnisse und Erfahrungen nach mehrjahriger Anwendung des molekularbiologischen Screening-Programms ist bereits berichtet worden (FLECK 1974

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Lambdamycin, ein Antibioticum aus dem Stamm IMET 31118 von Streptomyces glaucoachromogenes PRAUSER

Fleck

Strauss

Prauser

et al. 1976

J of Basic Microbiology

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Neue Selektionsmethode zur Gewinnung von Leistungsmutanten des Lambdamycin‐Bildners Streptomyces glaucoachromogenes mit Hilfe des thermophilen Phagen‐Wirtssystems Tal/Thermoactinomyces vulgaris

Fleck

1980

J of Basic Microbiology

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(E'ingegangen am 16. 7.1979) I n order to obtain high-producing mutants of the lambdamycin producer Streptomyces glaucoachromogenes IMET 31 118, a new selection technique using the thermophilic phage-host system Tal lThermoactinomyces vulgaris, was developed. Lambdamycin is a yellow-green pigment antibiotic of the chromoglycoside type with antimicrobial, antiviral, cancerostatic, and ergotropic activity i n vitro and in vivo. The physicochemical properties of lambdamycin resemble those of chartreusin. By means of the selection technique developed the determination of the concentration-dependent influence of lambdamycin on bacterial growth inhibition and Tal-phage development in the agar diffusion sphere of mutagen-treated colonies is possible without time and materialconsuming pre-tests. A positive correlation exists between the biosynthetic capacity of mutants on solid media and in fermentation liquors. Using this new selection technique, the titres of lambdamycin in fermentation liquors of mutants could be increased by 10 to 20 fold in comparison to the wild type strain. Lanibdaniycin ist ein gelb-grunes

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Lambdamycin, ein Antibioticum aus dem Stamm IMET 31118 von Streptomyces glaucoachromogenes PRAUSER II. Physikochemische Eigenschaften und Vergleich mit Chartreusin

Cited by 2 publications

References 9 publications

Lambdamycin, ein Antibioticum aus dem Stamm IMET 31118 von Streptomyces glaucoachromogenes PRAUSER

Lambdamycin, ein Antibioticum aus dem Stamm IMET 31118 von Streptomyces glaucoachromogenes PRAUSER

Neue Selektionsmethode zur Gewinnung von Leistungsmutanten des Lambdamycin‐Bildners Streptomyces glaucoachromogenes mit Hilfe des thermophilen Phagen‐Wirtssystems Tal/Thermoactinomyces vulgaris

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