Lambda-Interferons Inhibit Herpes Simplex Virus Type 2 Replication in Human Cervical Epithelial Cells by Activating the JAK/STAT Pathway

Zhu, Lei; Lü, Xuan; Zhu, Yufan; Peng, Cheng; Shi, Lei; Zhang, Yi; Tang, Jingfeng; Yang, Shaofeng; Zhou, Li

doi:10.7883/yoken.jjid.2016.465

Cited by 3 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, the study by Zaidan et al. (2019) ( 68 ) indicated a proviral effect of IL-32, suggesting that the effect of IL-32 on viral infection is complex. It is possible that IL-32 has different effects on different viruses or that its effects vary depending on the specific population that is studied.…”

Section: Discussionmentioning

confidence: 99%

The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis

Sattar,

Qaiser,

Kausar

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Many studies have investigated the antiviral activity of cytokines, including interleukin-6 (IL-6), interleukin-22 (IL-22), interleukin-32 gamma (IL-32γ), and interferon-lambda (IFN-λ) in diverse populations. This study aims to evaluate the role of these cytokines in inhibition of various human and animal viruses when administered exogenously. A comprehensive meta-analysis and systematic review were conducted on all the relevant studies from three databases. Standard mean differences (SMDs) of overall viral inhibition were used to generate the difference in the antiviral efficacy of these cytokines between control and experimental groups. A total of 4,618 abstracts for IL-6, 3,517 abstracts for IL-22, 2,160 abstracts for IL-32γ, and 1,026 abstracts for IFN-λ were identified, and 7, 4, 8, and 35 studies were included, respectively, for each cytokine. IFN-λ (SMD = 0.9540; 95% CI: 0.69–0.22) and IL-32γ (SMD = 0.459; 95% CI: 0.02–0.90) showed the highest influence followed by IL-6 (SMD = 0.456; CI: −0.04–0.95) and IL-22 (SMD = 0.244; 95% CI: −0.33–0.81). None of the cytokines represented heterogeneity (tau² > 0), but only IFN-λ indicated the funnel plot asymmetry (p = 0.0097). Results also indicated that IFN-λ and IL-32γ are more potent antivirals than IL-6 and IL-22. The collective findings of this study emphasize that exogenously administered pro-inflammatory cytokines, specifically IFN-λ and IL-32, exhibit a significant antiviral activity, thereby underscoring them as potent antiviral agents. Nonetheless, additional research is required to ascertain their clinical utility and potential for integration into combinatorial therapeutic regimens against viral infections.

show abstract

Section: Discussionmentioning

confidence: 99%

The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis

Sattar,

Qaiser,

Kausar

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…The phytochemical study of the fruits of G. multiora led to the isolation of nine new caged PPAPs, including adamantane type PPAPs (1-2), and homoadamantane type PPAPs (3)(4)(5)(6)(7)(8)(9). A new epimeric pair of isohypersampsonone B (5) and epiisohypersampsonone B (6) with an unusual hexahydrofuro [2,3-b]furan-diepoxy ring system were not separated due to the rapid equilibration between the two isomeric forms.…”

Section: Discussionmentioning

confidence: 99%

“…Its fruits are edible consisting of vitamins, proteins, and minerals, but may also provide pharmacologically active compounds. 5 Previous phytochemical investigations on the fruits led to isolation of seven new PPAPs with anti-inammatory activity, including two caged PPAPs garcimultiorone D and G. [6][7][8] Taken together, these results prompted us to investigate the isolation of further caged PPAPs form G. multiora and evaluate their biological activities. As a result, nine undescribed caged polycyclic polyprenylated acylphloroglucinols (PPAPs), including adamantane type PPAPs (1-2) and homoadamantane type PPAPs (3)(4)(5)(6)(7)(8)(9) were isolated from the fruits of G. multiora, along with three known analogues.…”

Section: Introductionmentioning

confidence: 99%

Adamantyl and homoadamantyl derivatives from Garcinia multiflora fruits

Chen

Teng

et al. 2019

RSC Adv.

View full text Add to dashboard Cite

show abstract

“…Notably, type III IFNs are essential for controlling viral infection in the upper respiratory tract, but there appears to be functional redundancy between type I and III IFNs in the lower respiratory tract [27]. In the genitourinary tract (e.g., human cervical and vaginal epithelial cells) and in the maternal decidual cells of the placenta, a similar dual effect was observed, and both types of IFNs are critical in protection against herpes virus-2 and the Zika virus [28,29]. Type III IFNs do not contribute substantially to the antiviral response in the central nervous system…”

Section: Antiviral Activities At Mucosal Barriersmentioning

confidence: 99%

The Role of Type III Interferons in Human Disease

Malik

Issekutz

2021

CIM

View full text Add to dashboard Cite

Purpose: This literature review summarizes the main immunological characteristics of type III interferons (IFN) and highlights the clinically relevant aspects and future therapeutic perspectives for these inflammatory molecules. Source: Relevant articles in PubMed MEDLINE from the first publication (2003) until 2020. N=101 articles were included in this review. Principal findings: Type III IFNs represent a relatively newly described inflammatory cytokine family. Although they induce substantially similar signalling to the well-known type I IFNs, significant functional differences make these molecules remarkable. Type III IFNs have extensive biological effects, contributing to the pathogenesis of several diseases and also offering new diagnostic and therapeutic approaches: 1) their potent anti-viral properties make them promising therapeutics against viral hepatitis and even against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is causing the current coronavirus disease 2019 (COVID-19) pandemic; 2) imbalances in the IFN-λs contribute to several forms of chronic inflammation (e.g., systemic and organ-specific autoimmune diseases) and potentially predict disease progression and therapeutic response to biologic therapies; and 3) the antitumor properties of the type III IFNs open up new therapeutic perspectives against malignant diseases. Conclusion: Over the last 18 years, researchers have gathered extensive information about the presence and role of these versatile inflammatory cytokines in human diseases, but further research is needed to clarify the mechanistic background of those observations. Better understanding of their biological activities will permit us to use type III IFNs more efficiently in new diagnostic approaches and individualized therapies, consequently improving patient care.

show abstract

Lambda-Interferons Inhibit Herpes Simplex Virus Type 2 Replication in Human Cervical Epithelial Cells by Activating the JAK/STAT Pathway

Cited by 3 publications

References 40 publications

The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis

The potential of IFN-λ, IL-32γ, IL-6, and IL-22 as safeguards against human viruses: a systematic review and a meta-analysis

Adamantyl and homoadamantyl derivatives from Garcinia multiflora fruits

The Role of Type III Interferons in Human Disease

Contact Info

Product

Resources

About