LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion

Founds, Sandra A.; Fallert-Junecko, Beth; Reinhart, Todd A.; Parks, W. Tony

doi:10.1016/j.placenta.2012.09.017

Cited by 16 publications

(11 citation statements)

References 20 publications

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“…Both interstitial and endovascular trophoblast in the perivascular regions of the spiral arteries undergoing arterial remodeling express a specific soluble receptor, leukocyte‐associated immunoglobulin‐like receptor (LAIR) 2 . A membrane bound homolog, LAIR1, was shown to be an inhibitory receptor found on the surface of multiple leukocytes including CD56 positive cells (suggesting uNK cells) .…”

Section: Interaction Between Unk Cells and Evts During Spiral Artery mentioning

confidence: 99%

“…A membrane bound homolog, LAIR1, was shown to be an inhibitory receptor found on the surface of multiple leukocytes including CD56 positive cells (suggesting uNK cells) . Both LAIR1 and LAIR2 compete for collagen as a primary ligand during late stages of spiral artery remodeling . Therefore, secretion of LAIR2 by EVTs has the potential to regulate uNK activation state by attenuating the LAIR1 inhibitory signaling and allowing uNK cell activation.…”

Section: Interaction Between Unk Cells and Evts During Spiral Artery mentioning

confidence: 99%

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Uterine Spiral Artery Remodeling: The Role of Uterine Natural Killer Cells and Extravillous Trophoblasts in Normal and High‐Risk Human Pregnancies

Tessier

Yockell‐Lelièvre

Gruslin

2014

American J Rep Immunol

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The process of uterine spiral artery remodeling in the first trimester of human pregnancy is an essential part of establishing adequate blood perfusion of the placenta that will allow optimal nutrient/waste exchange to meet fetal demands during later development. Key regulators of spiral artery remodeling are the uterine natural killer cells and the invasive extravillous trophoblasts. The functions of these cells as well as regulation of their activation states and temporal regulation of their localization within the uterine tissue are beginning to be known. In this review, we discuss the roles of these two cell lineages in arterial remodeling events, their interaction/influence on one another and the outcomes of altered temporal, and spatial regulation of these cells in pregnancy complications.

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Section: Interaction Between Unk Cells and Evts During Spiral Artery mentioning

confidence: 99%

Section: Interaction Between Unk Cells and Evts During Spiral Artery mentioning

confidence: 99%

Uterine Spiral Artery Remodeling: The Role of Uterine Natural Killer Cells and Extravillous Trophoblasts in Normal and High‐Risk Human Pregnancies

Tessier

Yockell‐Lelièvre

Gruslin

2014

American J Rep Immunol

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“…A unique polysialylated form of neural cell-adhesion molecule (NCAM) is expressed in the perivascular and plugged EVTs, but absent from villous trophoblasts and TCs ( Burrows et al, 1994 ). Recently, leukocyte-associated immunoglobulin-like receptor 2 (LAIR2) was also revealed to be a possible EVT-specific molecule ( Founds et al, 2010 , 2013 ).…”

Section: Introductionmentioning

confidence: 99%

PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration

et al. 2018

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Proper differentiation of trophoblast cells in the human placenta is a prerequisite for a successful pregnancy, and dysregulation of this process may lead to malignant pregnancy outcomes, such as preeclampsia. Finding specific markers for different types of trophoblast cells is essential for understanding trophoblast differentiation. Here, we report that placenta-specific protein 8 (PLAC8) is specifically expressed in the interstitial extravillous trophoblast cells (iEVTs) on the fetomaternal interface. Using model systems, including placental villi-decidua co-culture, iEVTs induction by using primary trophoblast cells or explants, etc., we found that PLAC8 promotes invasion and migration of iEVTs. Mechanistically, time-lapse imaging, GTPase activity assay, co-immunoprecipitation and RNA-seq studies show that PLAC8 increases the Cdc42 and Rac1 activities, and further induces the formation of filopodia at the leading edge of the migratory trophoblast cells. More interestingly, PLAC8 is significantly upregulated under hypoxia and expression of PLAC8 is higher in iEVTs from preeclamptic placentas when compared with those from the normal control placentas. Together, PLAC8 is a new marker for iEVTs and plays an important role in promoting trophoblast invasion and migration.

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“…Genomic in situ hybridization and protein immunohistochemical localizations were conducted in archived sections of termination tissues from pregnancies with unknown outcomes. These studies demonstrated specificity of LAIR2 expression by the invasive first trimester extravillous trophoblasts [ 38 ] and by trophoblasts involved with remodeling the decidual spiral arterioles [ 39 ]. LAIR2 functions in innate immunity.…”

Section: Discussionmentioning

confidence: 99%

Developing Potential Candidates of Preclinical Preeclampsia

Founds

Zeng

Lykins

et al. 2015

IJMS

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The potential for developing molecules of interest in preclinical preeclampsia from candidate genes that were discovered on gene expression microarray analysis has been challenged by limited access to additional first trimester trophoblast and decidual tissues. The question of whether these candidates encode secreted proteins that may be detected in maternal circulation early in pregnancy has been investigated using various proteomic methods. Pilot studies utilizing mass spectrometry based proteomic assays, along with enzyme linked immunosorbent assays (ELISAs), and Western immunoblotting in first trimester samples are reported. The novel targeted mass spectrometry methods led to robust multiple reaction monitoring assays. Despite detection of several candidates in early gestation, challenges persist. Future antibody-based studies may lead to a novel multiplex protein panel for screening or detection to prevent or mitigate preeclampsia.

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LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion

Cited by 16 publications

References 20 publications

Uterine Spiral Artery Remodeling: The Role of Uterine Natural Killer Cells and Extravillous Trophoblasts in Normal and High‐Risk Human Pregnancies

Uterine Spiral Artery Remodeling: The Role of Uterine Natural Killer Cells and Extravillous Trophoblasts in Normal and High‐Risk Human Pregnancies

PLAC8, a new marker for human interstitial extravillous trophoblast cells, promotes their invasion and migration

Developing Potential Candidates of Preclinical Preeclampsia

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