“…As far as the herringbone pattern in a duct flow is concerned, it has been demonstrated that two asymmetric counter-rotating flows are created by the herringbone-shaped grooves fabricated in a rectangular microchannel working in the creeping flow ( ) [ 22 , 37 , 38 , 39 , 40 , 41 , 42 ]. When the two flow portraits are projected onto a single plane normal to the ‒axis, the cross-sectional flow patterns from the two flows intersect each other, satisfying the necessary condition for chaotic advection in a three-dimensional geometrically periodic flow [ 20 , 21 , 43 ]. In the case of the flat membrane module ( Figure 1 ), unlike the two side walls of the microchannel, the two side surfaces of the computational domain (depicted in Figure 1 b) are not rigid walls but open boundaries, where a symmetric boundary condition is applied.…”