Lag times to steady state drug delivery by continuous intravenous infusion: direct comparison of peristaltic and syringe pump performance identifies contributions from infusion system dead volume and pump startup characteristics

Gibson, Lauren E.; Knudsen, Anders Steen; Arney, David; Deng, Hao; Sims, Nathaniel M.; Peterfreund, Robert A.

doi:10.1007/s10877-021-00790-1

Cited by 7 publications

(10 citation statements)

References 11 publications

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“…Furthermore, the results show that the problem occurs intermittently. Some amount of startup delay may be expected for infusion pumps, 3 and repetition 1 could be considered "normal." Repetition 3 and repetition 5 show large deviations initially and would barely pass the pump technical safety check requiring ±5% delivery accuracy after 6 minutes of infusion.…”

Section: Methodsmentioning

confidence: 99%

“…In this type of pump, an infusion set is sequentially compressed by a set of linearly arranged mechanical elements ("fingers"), which leads to a flow of fluid through the infusion set. 3 The use of infusion pumps may reduce some problems with medication administration, 4,5 but some errors remain despite their use. 6,7 For example, the use of a pump with dosing limits can avert dosing errors, but mistakes like hanging the wrong intravenous (IV) bag could still occur.…”

mentioning

confidence: 99%

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Flow Rate Deviation in Infusion Pump

Hult,

Zholobova,

Bäcklin

et al. 2024

Journal of Infusion Nursing

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Volumetric infusion pumps are used together with infusion sets to deliver medication to patients. Flow rate errors leading to overinfusion or underinfusion are known problems with these devices. Recently, numerous underinfusion flow rate errors were reported at a Swedish hospital. This experimental study reports on the investigation of these errors and specifically investigates the effect of operating the pump with a defective infusion set that has a visible elongation of the silicone segment of the set. Pump flow rate accuracy testing was performed using a gravimetric method. Experiments included a manipulated infusion set and a defective infusion set used in clinic. The use of a defective infusion set resulted in considerable accuracy deviations. The pump reported an infused amount greater than what was infused and did not provide any alarm or information indicating a reduced output. Using an elongated infusion set, the pump can be brought into an erroneous operating state where the infused amount delivered by the pump is considerably less than what has been programmed and what is shown on the pump display. This could put the patient at risk of not receiving the intended medication within the appropriate time.

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Flow Rate Deviation in Infusion Pump

Hult,

Zholobova,

Bäcklin

et al. 2024

Journal of Infusion Nursing

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“…In Vitro Swelling, Degradation, and Release Kinetics. To investigate the swelling behavior of microcarriers in vitro, dry microcarriers (W 0 ) were soaked in 5 mL of deionized water with pH = 7.4, and the deionized water was absorbed at 5,10,15,20,25,30,35,40,60,120, and 180 min, respectively. After weighing (W s ), the swelling rate swelling (%) = (W s − W 0 )/W 0 × 100% was calculated.…”

Section: Preparation Of Microcarriersmentioning

confidence: 99%

“…In short, various treatment technologies may limit their clinical translation due to indications, operation difficulty, and other factors. Drug therapy also present some disadvantages, such as off-target side effects or complications and slow absorptions of intravenous drip. , Biomaterial systems have been extensively investigated for several regenerative applications due to their tunable physical and biological properties − and have shown promise in improving flap repair. , …”

Section: Introductionmentioning

confidence: 99%

“…Drug therapy also present some disadvantages, such as off-target side effects or complications and slow absorptions of intravenous drip. 20,21 Biomaterial systems have been extensively investigated for several regenerative applications due to their tunable physical and biological properties 22−25 and have shown promise in improving flap repair. 26,27 Microcarriers usually refer to microspheres with a diameter of 90−350 μm.…”

Section: Introductionmentioning

confidence: 99%

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SDF-1 Functionalized Hydrogel Microcarriers for Skin Flap Repair

Liu

Wang

et al. 2022

ACS Biomater. Sci. Eng.

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Critically sized skin flaps used to treat skin defects often suffer from necrosis due to insufficient blood supply. Hence there is an urgent need to improve the survival rate of skin flaps by promoting local angiogenesis. The delivery of growth factor loaded microcarriers have shown promise in enhancing defect repair, however, their rapid clearance from the defect site limits their regenerative potential. Thus, it is critical to develop microcarriers which can promote the sustained release of bioactive factors to effectively stimulate tissue repair. This study aimed to develop a stromal cell-derived factor 1 (SDF-1) loaded microcarrier coated with Matrigel (MC@SDF-1@Mat) to promote skin flap repair. SEM imaging showed that the surface of the microcarrier was coated by a porous Matrigel film. The drug release experiment showed that the Matrigel-coated microcarriers enhanced the sustained release of the model drug methylene blue when compared to uncoated group. MC@SDF-1@Mat significantly promoted the proliferation, migration, and angiogenesis of HUVECs via CCK-8, wound healing assay, and tube formation assay, respectively. Moreover, the murine random skin flap model was further established and treated. It was found that the flap necrosis area in the MC@SDF-1@Mat treated group was significantly reduced. H&E and Masson staining showed the histological structure and collagen organization exhibited a normal phenotype in the MC@SDF-1@Mat treated group. Additionally, CD31 immunohistochemical analysis showed that the MC@SDF-1@Mat treated group exhibited the greatest degree of neovascularization. In conclusion, our SDF-1 functionalized gelatin-based hydrogel microcarrier has potential clinical applications in promoting skin flap repair and drug delivery.

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