Lae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides

Butchko, Robert A. E.; Brown, Daren W.; Busman, Mark; Tudzynski, Bettina; Wiemann, Philipp

doi:10.1016/j.fgb.2012.06.003

Cited by 102 publications

(75 citation statements)

References 61 publications

(78 reference statements)

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“…F. verticillioides IV B011 strain was able to produce relatively high amounts of toxins . A similar trend was also observed by Arino et al (2007), Brown et al (2012) and Butchko et al (2012). The highest concentration of fusarin C (0.7 mg L −1 ) was produced by the strain of F. verticillioides III K048.…”

Section: Toxin-producing Ability By Fungal Strainssupporting

confidence: 82%

Screening survey of co-production of fusaric acid, fusarin C, and fumonisins B1, B2 and B3 by Fusarium strains grown in maize grains

et al. 2014

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Fusarium species isolated from Belgian maize were screened for their ability to produce fusarin C, fusaric acid, fumonisins B1 (FB1), FB2 and FB3 in maize grains. First, cultivation of Fusarium species in Myro liquid medium allowed overcoming the shortage of the standard of fusarin C on the market. All Fusarium verticillioides produced much higher contents of mycotoxins in Myro compared to Fusarium graminearum or Fusarium venenatum. The optimization of the LC-MS/MS method resulted in low limits of detection and quantification for fusarin C, fusaric acid, FB1, FB2 and FB3 determination in maize grains. Its application for screening the potential toxin production ability evidenced that the concentrations of the analytes were significantly increased at various levels when F. verticillioides strains were cultivated in maize grains and reached 441 mg kg(-1) for fusaric acid, 74 mg kg(-1) for fusarin C, 1,301 mg kg(-1) for FB1, 367 mg kg(-1) for FB2 and 753 mg kg(-1) for FB3.

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Section: Toxin-producing Ability By Fungal Strainssupporting

confidence: 82%

Screening survey of co-production of fusaric acid, fusarin C, and fumonisins B1, B2 and B3 by Fusarium strains grown in maize grains

et al. 2014

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“…Our experimental data demonstrated that HP1BP3 plays a key role in the maintenance of high-order chromatin structure, which is a critical regulator of host cell transcriptional activity (63). We therefore assessed whether differences in gene transcription because of altered chromatin structure could be revealed by iTRAQ-based analysis of differentially expressed proteins in the HP1BP3-depleted cells.…”

Section: Mass Spectrometric Identification and Quantification Of Thementioning

confidence: 99%

Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression

Dutta

Ren

Hao

et al. 2014

Molecular & Cellular Proteomics

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The chromatin-associated proteome (chromatome) regulates cellular gene expression by restricting access of transcriptional machinery to template DNA, and dynamic re-modeling of chromatin structure is required to regulate critical cell functions including growth and replication, DNA repair and recombination, and oncogenic transformation in progression to cancer. Central to the control of these processes is efficient regulation of the host cell cycle, which is maintained by rapid changes in chromatin conformation during normal cycle progression. A global overview of chromatin protein organization is therefore essential to fully understand cell cycle regulation, but the influence of the chromatome and chromatin binding topology on host cell cycle progression remains poorly defined. Here we used partial MNase digestion together with iTRAQ-based high-throughput quantitative proteomics to quantify chromatin-associated proteins during interphase progression. We identified a total of 481 proteins with high confidence that were involved in chromatin-dependent events including transcriptional regulation, chromatin reorganization, and DNA replication and repair, whereas the quantitative data revealed the temporal interactions of these proteins with chromatin during interphase progression. When combined with biochemical and functional assays, these data revealed a strikingly dynamic association of protein HP1BP3 with the chromatin complex during different stages of interphase, and uncovered a novel regulatory role for this molecule in transcriptional regulation. We report that HP1BP3 protein maintains heterochromatin integrity during G 1-S progression and regulates the duration of G 1 phase to critically influence cell proliferative capacity. Molecular & Cellular

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“…In Penicillium citrinum and Penicillium chrysogenum, LaeA is required for the production of the polyketide ML-236B and penicillin, respectively (Baba et al, 2012;Kosalková et al, 2009). LaeA also activates the production of several SM in Fusarium verticillioides, including bikaverin, fumonisins, fusaric acid and fusarins (Butchko et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Regulation of secondary metabolite production in the fungal tomato pathogen Cladosporium fulvum

Griffiths

Saccomanno

Wit

et al. 2015

Fungal Genetics and Biology

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Lae1 regulates expression of multiple secondary metabolite gene clusters in Fusarium verticillioides

Cited by 102 publications

References 61 publications

Screening survey of co-production of fusaric acid, fusarin C, and fumonisins B1, B2 and B3 by Fusarium strains grown in maize grains

Screening survey of co-production of fusaric acid, fusarin C, and fumonisins B1, B2 and B3 by Fusarium strains grown in maize grains

Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression

Regulation of secondary metabolite production in the fungal tomato pathogen Cladosporium fulvum

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