Lactulose Mediates Suppression of Dextran Sodium Sulfate-Induced Colon Inflammation by Increasing Hydrogen Production

Chen, Xiao; Zhai, Xiao; Shi, Jianhui; Liu, Wenwu; Tao, Hengyi; Sun, Xuejun; Kang, Zhiwei

doi:10.1007/s10620-013-2563-7

Cited by 45 publications

(36 citation statements)

References 36 publications

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“…Comparable to the anti-inflammatory effect of FOS, resistant starch, lactulose, and isomalto-oligosaccharides (IMO) also attenuated intestinal inflammation in experimental models of IBD [18], [19], . The effect of these non-digestible carbohydrates on the composition and activity of intestinal microbiota overlaps only partially with the effect of FOS [21].…”

Section: Introductionmentioning

confidence: 99%

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Chemically Defined Diet Alters the Protective Properties of Fructo-Oligosaccharides and Isomalto-Oligosaccharides in HLA-B27 Transgenic Rats

et al. 2014

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Non-digestible oligosaccharides (NDO) were shown to reduce inflammation in experimental colitis, but it remains unclear whether microbiota changes mediate their colitis-modulating effects. This study assessed intestinal microbiota and intestinal inflammation after feeding chemically defined AIN-76A or rat chow diets, with or without supplementation with 8 g/kg body weight of fructo-oligosaccharides (FOS) or isomalto-oligosaccharides (IMO). The study used HLA-B27 transgenic rats, a validated model of inflammatory bowel disease (IBD), in a factorial design with 6 treatment groups. Intestinal inflammation and intestinal microbiota were analysed after 12 weeks of treatment. FOS and IMO reduced colitis in animals fed rat chow, but exhibited no anti-inflammatory effect when added to AIN-76A diets. Both NDO induced specific but divergent microbiota changes. Bifidobacteria and Enterobacteriaceae were stimulated by FOS, whereas copy numbers of Clostridium cluster IV were decreased. In addition, higher concentrations of total short-chain fatty acids (SCFA) were observed in cecal contents of rats on rat chow compared to the chemically defined diet. AIN-76A increased the relative proportions of propionate, iso-butyrate, valerate and iso-valerate irrespective of the oligosaccharide treatment. The SCFA composition, particularly the relative concentration of iso-butyrate, valerate and iso-valerate, was associated (P≤0.004 and r≥0.4) with increased colitis and IL-1 β concentration of the cecal mucosa. This study demonstrated that the protective effects of fibres on colitis development depend on the diet. Although diets modified specific cecal microbiota, our study indicates that these changes were not associated with colitis reduction. Intestinal inflammation was positively correlated to protein fermentation and negatively correlated with carbohydrate fermentation in the large intestine.

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Section: Introductionmentioning

confidence: 99%

“…Stimulation of intestinal lactobacilli and bifidobacteria by dietary IMO was observed in human studies [23], [24]. However, the effect of non-digestible carbohydrates other than FOS on intestinal microbiota in animal models for IBD remains poorly characterized [19], [20].…”

Section: Introductionmentioning

confidence: 99%

Chemically Defined Diet Alters the Protective Properties of Fructo-Oligosaccharides and Isomalto-Oligosaccharides in HLA-B27 Transgenic Rats

et al. 2014

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“…[25] Following TAA administration, it undergoes an extensive metabolism by microsomal CYP2E1 to acetamide and thioacetamide-S-oxide which causes disturbance in cell permeability, elevation in both intracellular Ca +2 concentration and nuclear volume associated with enlargement of nucleoli and inhibition of mitochondrial activity. [26] Thioacetamide-Soxide is further metabolized, at least in part by cytochrome-P-450 monooxygenase to further products, including a polar product sulfene, thioacetamide-S-dioxide, a very reactive compound.…”

Section: Resultsmentioning

confidence: 99%

“…[45] [25] found that lactulose can prevent the development of dextran sodium sulfate induced colitis and alleviate oxidative stress in the colon, probably by increasing endogenous H 2 production. Mobasher et al…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 99%

Biochemical and Pathophysiological Aspects of the Treatment of Hepatic Encephalopathy in Rats

Mobasher¹

2017

WJPPS

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Hepatic encephalopathy (HE) represents a diverse spectrum of complex neuropsychiatric disturbance resulting from liver disease and its concomitant metabolic and immunologic derangements.Hyperammonemia and inflammation cooperate to induce neurological alteration in hepatic encephalopathy. This study was conducted to elucidate the changes of serum, liver and brain proinflammatory cytokines in encephalopathy rats and to evaluate the hepato-protective activity of lactulose and/or taurine against thioacetamide (TAA) induced hepatic encephalopathy in rats. Acute hepatic encephalopathy (HE) in rats was induced by intraperitoneal injection of thioacetamide in 24 hours intervals for two consecutive days. The obtained results revealed a significant (p<0.05) increase in the levels of serum liver function tests (ALT, AST, ALP & bilirubin) in TAA rats group than those in control ones. In addition, the levels of ammonia and proinflammatory cytokines (IL-6, IL-1β & TNF-α) in serum, liver and brain were significantly (p<0.05) increased associated with a remarkable elevation in the level of serum S100β in TAA rats group. On the other hand, induction of hepatic encephalopathy caused a significant (p<0.05) decrease in albumin and total protein levels than those in control rats. When HE rats group was treated with lactulose or taurine and their mixture a considerable amelioration effects in all previous studied parameters were pronounced dependent on certain mechanisms.

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“…It's interesting to note that H2 therapy can be administered through inhalation, oral intake of hydrogen-rich water, injection of hydrogen-rich saline, direct diffusion of hydrogen: bath, eye drops and immersion, as well as increase hydrogen in intestine [11,[61][62][63][64][65][66][67][68][69]. Although each delivery way has its own characteristic and advantages, injection of hydrogen-rich saline allows enough amount of hydrogen to have its own antioxidant, anti-inflammation, anti-apoptosis effect at the shortest time [11,70].…”

Section: Proposed Delivery Way Of Hydrogenmentioning

confidence: 99%

Hydrogen Medicine Therapy: An Effective and Promising Novel Treatment for Multiple Organ Dysfunction Syndrome (MODS) Induced by Influenza and Other Viral Infections Diseases?

Hu¹

2017

SOJMID

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Hydrogen, a non-cytotoxic molecule, is one of nature's most simple elements [1,2]. Recent studies revealed that intraperitoneal injection of hydrogen-rich saline has surprising anti-inflammation, anti-oxidant, anti-apoptosis effects and protected organism against polymicrobial sepsis injury, acute peritonitis injury both by reducing oxidative stress and via decreasing mass proinflammatory responses. It is also well known that the majority of viral -induced tissue damage and discomfort are mainly caused by an inflammatory cytokine storm and oxidative stress rather than by virus itself [3][4][5]. Studies have shown that suppressing the cytokine storm and reducing oxidative stress can significantly alleviate the symptoms of influenza and other severe viral infections diseases [3][4][5][6][7]. However, none of the studies have been focused on the solution as an anti-virus infection therapy yet. Therefore, we hypothesize that hydrogen-rich solution therapy may be a safe, reliable, and effective treatment for Multiple Organ Dysfunction Syndrome (MODS) induced by influenza and other viral infectious diseases.

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Lactulose Mediates Suppression of Dextran Sodium Sulfate-Induced Colon Inflammation by Increasing Hydrogen Production

Abstract: Lactulose can prevent the development of DSS-induced colitis and alleviate oxidative stress in the colon, as measured by MDA and MPO, probably by increasing endogenous H2 production.

Cited by 45 publications

References 36 publications

Chemically Defined Diet Alters the Protective Properties of Fructo-Oligosaccharides and Isomalto-Oligosaccharides in HLA-B27 Transgenic Rats

Chemically Defined Diet Alters the Protective Properties of Fructo-Oligosaccharides and Isomalto-Oligosaccharides in HLA-B27 Transgenic Rats

Biochemical and Pathophysiological Aspects of the Treatment of Hepatic Encephalopathy in Rats

Hydrogen Medicine Therapy: An Effective and Promising Novel Treatment for Multiple Organ Dysfunction Syndrome (MODS) Induced by Influenza and Other Viral Infections Diseases?

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