Lactulose accelerates liver regeneration in rats by inducing hydrogen

Yu, Jianhua; Zhang, Weiguang; Zhang, Rongguo; Ruan, Xinxian; Ren, Peitu; Lu, Binfeng

doi:10.1016/j.jss.2015.01.034

Cited by 30 publications

(25 citation statements)

References 20 publications

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“…Subsequent studies indicate that hydrogen activates the Nrf2-Keap1 system. Hydrogen activates Nrf2 [ 36 , 81 – 87 ] and its downstream heme oxygenase-1 (HO-1) [ 36 , 51 , 52 , 65 , 71 , 81 , 82 , 84 – 93 ]. Kawamura and colleagues reported that hydrogen did not mitigate hyperoxic lung injury in Nrf2 -knockout mice [ 82 ].…”

Section: Introductionmentioning

confidence: 99%

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

et al. 2015

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Therapeutic effects of molecular hydrogen for a wide range of disease models and human diseases have been investigated since 2007. A total of 321 original articles have been published from 2007 to June 2015. Most studies have been conducted in Japan, China, and the USA. About three-quarters of the articles show the effects in mice and rats. The number of clinical trials is increasing every year. In most diseases, the effect of hydrogen has been reported with hydrogen water or hydrogen gas, which was followed by confirmation of the effect with hydrogen-rich saline. Hydrogen water is mostly given ad libitum. Hydrogen gas of less than 4 % is given by inhalation. The effects have been reported in essentially all organs covering 31 disease categories that can be subdivided into 166 disease models, human diseases, treatment-associated pathologies, and pathophysiological conditions of plants with a predominance of oxidative stress-mediated diseases and inflammatory diseases. Specific extinctions of hydroxyl radical and peroxynitrite were initially presented, but the radical-scavenging effect of hydrogen cannot be held solely accountable for its drastic effects. We and others have shown that the effects can be mediated by modulating activities and expressions of various molecules such as Lyn, ERK, p38, JNK, ASK1, Akt, GTP-Rac1, iNOS, Nox1, NF-κB p65, IκBα, STAT3, NFATc1, c-Fos, and ghrelin. Master regulator(s) that drive these modifications, however, remain to be elucidated and are currently being extensively investigated.

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Section: Introductionmentioning

confidence: 99%

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

et al. 2015

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“…Liver regeneration evolved presumably to protect wild animals from catastrophic liver loss caused by toxins or tissue injury (Wu et al 2015). Lactulose administration accelerates post hepatectomized liver regeneration in rats by inducing hydrogen, which may result from attenuation of the oxidative stress response and excessive inflammatory response (Yu et al 2015). Long-term administration of silymarin significantly increased the survival time of cirrhotic alcoholic patients (Feher and Lengyel 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

Pour

Mirazi

Alaei

et al. 2017

Can. J. Physiol. Pharmacol.

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Silymarin, a mixture of antihepatotoxic flavonolignans used in the treatment of liver diseases, and lactulose, a nonabsorbable synthetic disaccharide, were investigated to analyze their probable synergic and healing effects in a hepatic cirrhotic rat model. Liver damage was induced by the administration and subsequent withdrawal of thioacetamide. The significant decrease in liver enzymes and malondialdehyde levels confirmed the curative effects of silymarin and lactulose. In the silymarin + lactulose group, liver enzyme and malondialdehyde levels were significantly reduced compared with those in the thioacetamide group. All treatments led to liver regeneration and triggered enhanced regeneration. Silymarin and lactulose alone or in combination have potent curative effects and reduce thioacetamide-induced liver damage.

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“…Administration of lactulose accelerates posthepatectomized liver regeneration in rats by inducing hydrogen, which may result from offsetting oxidative stress and inflammatory response [91]. Lactulose if orally administered could adjust the imbalance between the oxidation system and the antioxidant system of HCC patients with hepatocirrhosis and hypersplenism after interventional therapies, alleviate liver injury, and improve the antitumor immunity and prognosis [92] (Figure 7).…”

Section: Fructans Prebioticsmentioning

confidence: 99%

Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

Fatima

Akhtar

Sheikh

2017

Canadian Journal of Gastroenterology and Hepatology

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Hepatocellular carcinoma is one of the fatal malignancies and is considered as the third leading cause of death. Mutations, genetic modifications, dietary aflatoxins, or impairments in the regulation of oncogenic pathways may bring about liver cancer. An effective barrier against hepatotoxins is offered by gut-liver axis as a change in gut permeability and expanded translocation of lipopolysaccharides triggers the activation of Toll-like receptors which stimulate the process of hepatocarcinogenesis. Prebiotics, nondigestible oligosaccharides, have a pivotal role to play when it comes to inducing an antitumor effect. A healthy gut flora balance is imperative to downregulation of inflammatory cytokines and reducing lipopolysaccharides induced endotoxemia, thus inducing the antitumor effect.

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Lactulose accelerates liver regeneration in rats by inducing hydrogen

Cited by 30 publications

References 20 publications

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles -

Effects of lactulose and silymarin on liver enzymes in cirrhotic rats

Prebiotics: A Novel Approach to Treat Hepatocellular Carcinoma

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