Lactosucrose Inhibits Body Fat Accumulation in Rats by Decreasing Intestinal Lipid Absorption

Mizote, Akiko; Taniguchi, Yoshifumi; Takei, Yasuhiko; Koya‐Miyata, Satomi; Kohno, Keizo; Iwaki, Kanso; Kurose, Mayumi; Oku, Kenji; Chaen, Hiroto; Fukuda, Shigeharu

doi:10.1271/bbb.80658

Cited by 18 publications

(12 citation statements)

References 16 publications

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“…The SDF fraction of the albedo TDF inhibited porcine pancreatic lipase activity, similar to that reported for lactosucrose (12). Previous studies have demonstrated that water extracts from the segment membranes of various citrus fruits have much stronger inhibitory activities on pancreatic lipase, with IC50 values less than 0.5 mg/mL (5).…”

Section: Discussionsupporting

confidence: 82%

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Hypolipidemic and Bifidogenic Potentials in the Dietary Fiber Prepared from Mikan (Japanese Mandarin Orange: Citrus unshiu) Albedo

Iwata

Hotta

Goto

2012

J Nutr Sci Vitaminol

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SummaryThe albedo is the white part of the citrus peel, which acts as a water reservoir for the juice sacs, seeds and leaves in times of drought. As the functionality of the albedo is unknown, we examined in this study the hypolipidemic and bifidogenic potentials of dietary fiber (DF) prepared from the Mikan (Japanese mandarin orange: Citrus unshiu ) albedo. The albedo was obtained from Mikan harvested in Arida, Wakayama Prefecture, and total DF (TDF), water soluble DF (SDF) and water insoluble DF (IDF) were extracted. Albedo TDF contained arabinose (37.21%), galactose (16.05%), xylose (18.30%) and glucose (13.94%), but did not contain detectable amounts of galacturonic acid. Albedo SDF inhibited the enzymatic digestion of triolein by pancreatic lipase in vitro. The SDF, at a concentration of 80 mg per 6 mL of substrate solution, significantly inhibited the activity of this enzyme ( Ͼ 50%). As compared to a control group on a 5% cellulose diet, rats fed a diet containing 1% albedo TDF for 4 wk showed significantly decreased serum triacylglycerol concentrations, increased fecal lipid excretion, and no changes in hepatic lipid content (triacylglycerol, total cholesterol, and phospholipid) or serum concentrations of total cholesterol or phospholipid. Consumption of albedo TDF also increased the number of bifidobacteria in the cecum. In this report, we have demonstrated that consumption of albedo TDF increased the levels bifidobacteria in the rat cecum, and decreased serum triacylglycerol concentrations due to the accelerated lipid excretion into the feces caused by the inhibition of pancreatic lipase.

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Section: Discussionsupporting

confidence: 82%

“…Lipase activity was determined by the rate of oleic acid released from triolein ( 12 ). Inhibition of lipase activity was estimated by the reduction of the activity brought about by SDF addition.…”

Section: Methodsmentioning

confidence: 99%

Hypolipidemic and Bifidogenic Potentials in the Dietary Fiber Prepared from Mikan (Japanese Mandarin Orange: Citrus unshiu) Albedo

Iwata

Hotta

Goto

2012

J Nutr Sci Vitaminol

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“…1 Like many other oligosaccharides, lactosylfructoside is indigestible and shows a range of physiological functions. It has the ability to maintain intestinal microflora by promoting the multiplication of Bifidobacterium, [2][3][4][5] inhibit fat accumulation, [6][7][8] and improve the absorption of intestinal calcium. 9,10 Moreover, lactosylfructoside shows a potential beneficial immunoregulatory effect.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of lactosylfructoside by an intracellular levansucrase from Bacillus methylotrophicus SK 21.002

Wu¹,

Zhang²,

Mu³

et al. 2015

Carbohydrate Research

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“…Rats (Honda et al, 1999;Yoneyama et al, 1992b) Dogs (Terada et al, 1992) Cats (Terada et al, 1993) Chickens ) Fujita et al, 1991aIwagaki et al, 1991;Kumemura et al, 1992;Iwagaki et al, 1993;Takumi et al, 2001;García-Cayuela et al, 2014;Li et al, 2015 Decrease of faecal pH, production of SCFAs a and gases, reduction of putrefactive products Rats (Yoneyama et al, 1992b) Dogs (Terada et al, 1992) Cats (Terada et al, 1993) Chickens Fishes (Kihara et al, 1995;Kihara & Sakata, 2001;) Kumemura et al, 1992 Enhancement of intestinal absorption of minerals Rats (Fujita et al, 1999;Kishino et al, 2006) Fishes (Kihara et al, 2007 Practical effects Prevention of obesity Rats (Mizote et al, 2009;Okuda & Han, 2001) Improvement of the immune response…”

Section: Enhancement Of Beneficial Bacteria And/or Inhibition Of Pathmentioning

confidence: 99%

“…Moreover, lactosucrose caused a reduction in the parametrial adipose tissue weight in rats (Okuda & Han, 2001) due to the suppression of body fat accumulation. For that reason, lactosucrose was suggested as a promising dietary supplement for obesity prevention (Mizote et al, 2009). …”

Section: Enhancement Of Beneficial Bacteria And/or Inhibition Of Pathmentioning

confidence: 99%

Perspectives on the biotechnological production and potential applications of lactosucrose: A review

Silvério

Macedo

Teixeira

et al. 2015

Journal of Functional Foods

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Available online A B S T R A C TLactosucrose is a synthetic trisaccharide composed of galactose, glucose and fructose. This compound is obtained through enzymatic synthesis using lactose and sucrose as substrates. The enzymes involved in the process are able to catalyse both hydrolysis and transfer reactions. The yield and productivity of the process are usually affected by the occurrence of parallel hydrolysis of the newly formed product (lactosucrose). Therefore, it is important to find efficient strategies to avoid or minimize product degradation. Furthermore, in the last decades the demand for lactosucrose has significantly increased. This compound is considered a potential prebiotic and several beneficial effects associated to its consumption have been described. As a result, it has been included in the formulations of functional foods. This review covers the most relevant information about lactosucrose, including its synthesis and purification, beneficial effects at physiological level, and also its potential applications.

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Lactosucrose Inhibits Body Fat Accumulation in Rats by Decreasing Intestinal Lipid Absorption

Cited by 18 publications

References 16 publications

Hypolipidemic and Bifidogenic Potentials in the Dietary Fiber Prepared from Mikan (Japanese Mandarin Orange: Citrus unshiu) Albedo

Hypolipidemic and Bifidogenic Potentials in the Dietary Fiber Prepared from Mikan (Japanese Mandarin Orange: Citrus unshiu) Albedo

Biosynthesis of lactosylfructoside by an intracellular levansucrase from Bacillus methylotrophicus SK 21.002

Perspectives on the biotechnological production and potential applications of lactosucrose: A review

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