Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant

Bhattacharya, Kunal; El-Sayed, Ramy; Andón, Fernando Torres; Mukherjee, Sourav P.; Gregory, Joshua A.; Li, Hu; Zhao, Yinchen; Seo, Wanji; Fornara, Andrea; Brandner, Birgit D.; Toprak, Muhammet S.; Leifer, Klaus; Star, Alexander; Fadeel, Bengt

doi:10.1016/j.carbon.2015.05.022

Cited by 53 publications

(36 citation statements)

References 38 publications

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“…LPO is a secreted enzyme that has been shown to be important for airway defense against infection. Indeed, efficient LPO-mediated degradation of carboxylated SWCNTs pre-coated with porcine lung surfactant (Curosurf) was documented by Raman spectroscopy, and we also observed biodegradation of SWCNTs in cell-free broncheoalveolar lavage fluid [154]. Thus, the presence of a protein-lipid corona [88] does not appear to interfere with degradation.…”

Section: Biodegradation Of Carbon-based Nanomaterialsmentioning

confidence: 86%

“…Indeed, MPO, EPO, and LPO have all been shown to catalyze the degradation of carboxylated SWCNTs in vitro in the presence of H 2 O 2 and halide ions through the production of reactive radical intermediates in addition to hypohalous acids [152–154] (Figure 4). Degradation of oxidized SWCNTs has been demonstrated upon incubation with MPO and H 2 O 2 , in addition to incubation only with sodium hypochlorite (NaOCl).…”

Section: Biodegradation Of Carbon-based Nanomaterialsmentioning

confidence: 99%

“…Importantly, in the studies cited above, degradation was shown to occur in a complex biological environment, i.e., in cell culture in the presence of fetal bovine serum, or in the lungs of mice, suggesting that bio-corona formation does not prevent degradation of carbon-based nanomaterials. To probe this in further detail, we recently investigated whether LPO-mediated degradation could occur in the presence of lung surfactant [154]. LPO is a secreted enzyme that has been shown to be important for airway defense against infection.…”

Section: Biodegradation Of Carbon-based Nanomaterialsmentioning

confidence: 99%

See 2 more Smart Citations

Biological interactions of carbon-based nanomaterials: From coronation to degradation

Bhattacharya

Mukherjee

Gallud

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

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347

226

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Carbon-based nanomaterials including single- and multi-walled carbon nanotubes, graphene oxide, fullerenes and nanodiamonds are potential candidates for various applications in medicine such as drug delivery and imaging. However, the successful translation of nanomaterials for biomedical applications is predicated on a detailed understanding of the biological interactions of these materials. Indeed, the potential impact of the so-called bio-corona of proteins, lipids, and other biomolecules on the fate of nanomaterials in the body should not be ignored. Enzymatic degradation of carbon-based nanomaterials by immune-competent cells serves as a special case of bio-corona interactions with important implications for the medical use of such nanomaterials. In the present review, we highlight emerging biomedical applications of carbon-based nanomaterials. We discuss recent studies on nanomaterial ‘coronation’ and how this impacts on biodistribution and targeting along with studies on the enzymatic degradation of carbon-based nanomaterials, and the role of surface modification of nanomaterials for these biological interactions.

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Section: Biodegradation Of Carbon-based Nanomaterialsmentioning

confidence: 86%

Section: Biodegradation Of Carbon-based Nanomaterialsmentioning

confidence: 99%

Section: Biodegradation Of Carbon-based Nanomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Biological interactions of carbon-based nanomaterials: From coronation to degradation

Bhattacharya

Mukherjee

Gallud

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

Self Cite

347

226

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“…On the other hand, the possible persistence of GO in the body raises doubts regarding the successful use of GBMs in clinical practice. However, we and others have shown the degradation ability of carbon nanomaterials incubated with different peroxidases . In addition, previous studies demonstrated in vivo degradation …”

Section: Introductionmentioning

confidence: 72%

A Biodegradable Multifunctional Graphene Oxide Platform for Targeted Cancer Therapy

Martín

Ruiz

Keshavan

et al. 2019

Adv Funct Materials

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The design of multifunctional materials able to both selectively deliver a drug into cells in a targeted manner and display an enhanced propensity for biodegradation is an important goal. Here, graphene oxide (GO) is functionalized with the chemotactic peptide N-formyl-methionyl-leucylphenylalanine (fMLP) known to interact with the formyl peptide receptor, which is expressed in different cancer cells, including cervical carcinoma cells. This study highlights the ability of GOfMLP for targeted drug delivery and cancer cell killing and the subsequent degradation capacity of the hybrid. Biodegradation is assessed via Raman spectroscopy and transmission electron microscopy. The results show that GOfMLP is susceptible to faster myeloperoxidase-mediated degradation. The hybrid material, but not GO, is capable of inducing neutrophil degranulation with subsequent degradation, being the first study showing inducible neutrophil degradation by the nanomaterial itself with no prior activation of the cells. In addition, confocal imaging and flow cytometry using HeLa cells demonstrate that GOfMLP is able to deliver the chemotherapeutic agent doxorubicin faster into cells, inducing higher levels of apoptosis, when compared to nonfunctionalized GO. The results reveal that GOfMLP is a promising carrier able to efficiently deliver anticancer drugs, being endowed with the ability to induce its own biodegradation.

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“…Allen et al first reported that carboxylated SWCNTs could be slowly degraded by oxidation via a highly reactive intermediate resulted from the reaction of horseradish peroxidase (HRP) with H 2 O 2 ( Figure a–f). Later, other carbon‐based nanomaterials including GO and MWCNTs have also been demonstrated as degradable by HRP and H 2 O 2 ,, and SWCNTs have been reported to be degraded by other mammalian peroxidases with the catalytic heme active site in the presence of H 2 O 2 or halide ions . As shown in Figure g–k, GO could be oxidized to form holes on its basal plane after 5 and 10 d of HRP/H 2 O 2 treatment.…”

Section: Safe‐by‐design Strategies For Nanomedicinementioning

confidence: 91%

A Safe‐by‐Design Strategy towards Safer Nanomaterials in Nanomedicines

et al. 2019

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.201805391.The marriage of nanotechnology and medicine offers new opportunities to fight against human diseases. Benefiting from their unique optical, thermal, magnetic, or redox properties, a wide range of nanomaterials have shown potential in applications such as diagnosis, drug delivery, or tissue repair and regeneration. Despite the considerable success achieved over the past decades, the newly emerging nanomedicines still suffer from an incomplete understanding of their safety risks, and of the relationships between their physicochemical characteristics and safety profiles. Herein, the most important categories of nanomaterials with clinical potential and their toxicological mechanisms are summarized, and then, based on this available information, an overview of the principles in developing safe-by-design nanomaterials for medical applications and of the recent progress in this field is provided. These principles may serve as a starting point to guide the development of more effective safe-by-design strategies and to help identify the major knowledge and skill gaps.

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Lactoperoxidase-mediated degradation of single-walled carbon nanotubes in the presence of pulmonary surfactant

Cited by 53 publications

References 38 publications

Biological interactions of carbon-based nanomaterials: From coronation to degradation

Biological interactions of carbon-based nanomaterials: From coronation to degradation

A Biodegradable Multifunctional Graphene Oxide Platform for Targeted Cancer Therapy

A Safe‐by‐Design Strategy towards Safer Nanomaterials in Nanomedicines

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