Lactones from the pericarps of Litsea japonica and their anti-inflammatory activities

Ngo, Quynh-Mai Thi; Cao, Thao Quyen; Tran, Phi-Long; Kim, Jeong Ah; Seo, Sang‐Tae; Kim, Jin-Cheol; Woo, Mi Hee; Lee, Jeong Hyung; Min, Byung Sun

doi:10.1016/j.bmcl.2018.04.023

Cited by 14 publications

(6 citation statements)

References 23 publications

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“…L. japonica has been used as a herbal medicine, and its fruit extract has been known to improve the symptoms of many diseases, including osteoarthritis [ 36 ], diabetes-induced retinal neurodegeneration [ 71 ], and blood-retinal barrier breakdown [ 72 ]. Recent studies about L. japonica have shown the effect of its fruit extract on inflammation in LPS-stimulated RAW264.7 cells [ 33 , 73 , 74 , 75 , 76 ]. One study suggested that the anti-inflammatory activity of L. japonica extract was due to its antioxidant activity, mediated by the inhibition of inducible nitric oxide synthase (iNOS) [ 74 ].…”

Section: Discussionmentioning

confidence: 99%

“…The leaves and stems of L. japonica used in this experiment were collected from Jeju Island in Korea by the Jeju Biodiversity Research Institute, Jeju Technopark. The dried L. japonica leaves (100 g) were extracted with 80% ethanol three times for 24 h each at room temperature [ 76 ]. The lyophilized extract was sonicated six times for 8 s in 1 mL of 80% ethanol, mixed thoroughly, and stored in a refrigerator at −20 °C until use.…”

Section: Methodsmentioning

confidence: 99%

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Litsea japonica Leaf Extract Suppresses Proinflammatory Cytokine Production in Periodontal Ligament Fibroblasts Stimulated with Oral Pathogenic Bacteria or Interleukin-1β

Yun

Ahn

Yoon

et al. 2018

IJMS

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Periodontal disease, a chronic disease caused by bacterial infection, eventually progresses to severe inflammation and bone loss. Regulating excessive inflammation of inflamed periodontal tissues is critical in treating periodontal diseases. The periodontal ligament (PDL) is primarily a connective tissue attachment between the root and alveolar bone. PDL fibroblasts (PDLFs) produce pro-inflammatory cytokines in response to bacterial infection, which could further adversely affect the tissue and cause bone loss. In this study, we determined the ability of Litsea japonica leaf extract (LJLE) to inhibit pro-inflammatory cytokine production in PDLFs in response to various stimulants. First, we found that LJLE treatment reduced lipopolysaccharide (LPS)-induced pro-inflammatory cytokine (interleukin-6 and interleukin-8) mRNA and protein expression in PDLFs without cytotoxicity. Next, we observed the anti-inflammatory effect of LJLE in PDLFs after infection with various oral bacteria, including Fusobacterium nucleatum, Porphyromonas gingivalis, Treponema denticola, and Tannerella forsythia. These anti-inflammatory effects of LJLE were dose-dependent, and the extract was effective following both pretreatment and posttreatment. Moreover, we found that LJLE suppressed the effect of interleukin-1 beta-induced pro-inflammatory cytokine production in PDLFs. Taken together, these results indicate that LJLE has anti-inflammatory activity that could be exploited to prevent and treat human periodontitis by controlling inflammation.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Litsea japonica Leaf Extract Suppresses Proinflammatory Cytokine Production in Periodontal Ligament Fibroblasts Stimulated with Oral Pathogenic Bacteria or Interleukin-1β

Yun

Ahn

Yoon

et al. 2018

IJMS

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“…According to a recent review by Azhar and Salleh (2020) [107], 20 and 25 compounds have been reported in the essential oils of the seed and mesocarp of the L. japonica fruit respectively, where Germacrene D and caryophyllene were identified as the major constituents. Various lactones including akolactones A, B, D and E, hamabiwalactones A and B, lincomolide C, lisealactones H 1 and H 2 , litseakolide B, litsealactones A and B and litsenolides A 1 , A 2 , B 1 , B 2 , C 1 , C 2 , D 1 , D 2 , E 1 , E 2 and F 1 were also isolated from various parts of the plant [103,[108][109][110]. In addition, four flavonoids including epicatechin, afzelin, quercitrin and tiliroside, were isolated from L. japonica leaves [104].…”

Section: Litsea Japonica (Thunb) Jussieumentioning

confidence: 99%

“…Reports on the traditional use of the plant in folk medicine are limited. However, various biological studies have shown that the extracts from various parts of L. japonica possess analgesic [24], anti-inflammatory [103], anti-complement [104] and antidiabetic properties [105] and are prospective therapies for diabetic retinopathy [106] and osteoarthritis [74].…”

Section: Litsea Japonica (Thunb) Jussieumentioning

confidence: 99%

“…Meanwhile, hamabiwa A and B lactones have exhibited significant antinociceptive activity in both peripheral and central nervous models of pain [24]. In another study, litsenolides A 1 , A 2 , B 1 , B 2 , D 2 , E 2 and F 1 , litseakolide B and lincomolide C demonstrated potent nitric oxide (NO) inhibition in lipopolysaccharide (LPS)-stimulated RAW264.7 cells [103]. Furthermore, litseakolide B and litsenolides A 2 , B 2 and F 1 downregulated inducible nitric oxide synthase (iNOS) and COX-2 expression while litsenolide A 2 suppressed the mRNA expression of iNOS, COX-2, IL-6 and TNF-α [103].…”

Section: Litsea Japonica (Thunb) Jussieumentioning

confidence: 99%

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The Analgesic Potential of Litsea Species: A Systematic Review

Goh,

Samsul,

Mohaimin

et al. 2024

Molecules

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Various plant species from the Litsea genus have been claimed to be beneficial for pain relief. The PRISMA approach was adopted to identify studies that reported analgesic properties of plants from the Litsea genus. Out of 450 records returned, 19 primary studies revealed the analgesic potential of nine Litsea species including (1) Litsea cubeba, (2) Litsea elliptibacea, (3) Litsea japonica, (4) Litsea glutinosa, (5) Litsea glaucescens, (6) Litsea guatemalensis, (7) Litsea lancifolia, (8) Litsea liyuyingi and (9) Litsea monopetala. Six of the species, 1, 3, 4, 7, 8 and 9, demonstrated peripheral antinociceptive properties as they inhibited acetic-acid-induced writhing in animal models. Species 1, 3, 4, 8 and 9 further showed effects via the central analgesic route at the spinal level by increasing the latencies of heat stimulated-nocifensive responses in the tail flick assay. The hot plate assay also revealed the efficacies of 4 and 9 at the supraspinal level. Species 6 was reported to ameliorate hyperalgesia induced via partial sciatic nerve ligation (PSNL). The antinociceptive effects of 1 and 3 were attributed to the regulatory effects of their bioactive compounds on inflammatory mediators. As for 2 and 5, their analgesic effect may be a result of their activity with the 5-hydroxytryptamine 1A receptor (5-HT1AR) which disrupted the pain-stimulating actions of 5-HT. Antinociceptive activities were documented for various major compounds of the Litsea plants. Overall, the findings suggested Litsea species as good sources of antinociceptive compounds that can be further developed to complement or substitute prescription drugs for pain management.

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Anti‐inflammatory effects of chemical components from Ginkgo biloba L. male flowers on lipopolysaccharide‐stimulated RAW264.7 macrophages

Li¹,

Li²,

Hou

et al. 2019

Phytotherapy Research

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Ginkgo biloba L., well known as living fossil, have various pharmacological activities. Eighteen compounds were isolated from Ginkgo male flowers including a novel matsutake alcohol glycoside, Ginkgoside A (1), and 17 known compounds—calaliukiuenoside (2), benzylalcohol O‐α‐l‐arabinopyranosyl‐(1 → 6)‐β‐d‐glucopyranoside (3), amentoflavone (4), sciadopitysin (5), bilobetin (6), isoginkgetin (7), olivil 4‐O‐β‐d‐glucopyranoside (8), dihydrodehydrodiconiferyl alcohol‐4‐O‐β‐d‐glucoside (9), (+)‐cyclo‐olivil‐6‐O‐β‐d‐glucopyranoside (10), (−)‐isolariciresinol 4‐O‐β‐d‐glucopyranoside (11), coniferin (12), trans‐cinnamic acid‐4‐O‐β‐d‐glucopyranoside (13), p‐coumaryl alchol glucoside (14), stroside B (15), methylconiferin (16), cis‐p‐coumaric acid 4‐O‐β‐d‐glucopyranoside (17), and cis‐coniferin (18). Thirteen of these compounds had not previously found in Ginkgo. All extractive fractions and isolated compounds were evaluated for their anti‐inflammatory ability in the lipopolysaccharide‐induced RAW264.7 macrophages. The ethanol extract of Ginkgo flowers and the chloroform and ethyl acetate fractions can significantly decrease nitric oxide (NO), interleukin‐6 (IL‐6), and prostaglandin E2 (PGE2) production at 100 μg/ml. The most effective compounds, bilobetin (6) and isoginkgetin (7), elevated the NO inhibition ratios to 80.19% and 82.37% at 50 μM, respectively. They also exhibited significant dose‐dependent inhibitory effects on tumor necrosis factor‐α, IL‐6, PGE2, inducible NO synthase mRNA, and cyclooxygenase‐2 mRNA levels. So they can be promising candidates for the development of new anti‐inflammatory agents.

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Lactones from the pericarps of Litsea japonica and their anti-inflammatory activities

Cited by 14 publications

References 23 publications

Litsea japonica Leaf Extract Suppresses Proinflammatory Cytokine Production in Periodontal Ligament Fibroblasts Stimulated with Oral Pathogenic Bacteria or Interleukin-1β

Litsea japonica Leaf Extract Suppresses Proinflammatory Cytokine Production in Periodontal Ligament Fibroblasts Stimulated with Oral Pathogenic Bacteria or Interleukin-1β

The Analgesic Potential of Litsea Species: A Systematic Review

Anti‐inflammatory effects of chemical components from Ginkgo biloba L. male flowers on lipopolysaccharide‐stimulated RAW264.7 macrophages

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