Lactogenic effect of Polyscias scutellaria extract to maintain postpartum prolactin and oxytocin in lactating rats

Budiono, Budiono; Pertami, Sumirah Budi; Kasiati,; Arifah, Siti Nur; Atho'illah, Mochammad Fitri

doi:10.1016/j.jaim.2022.100580

Cited by 6 publications

(7 citation statements)

References 39 publications

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“…The higher phenol compounds could increase their function as antioxidants due to the ability to eliminate free and peroxide radicals, enhancing their effectiveness in inhibiting lipid oxidation. 16,23 The length of fermentation time also affected the antioxidant content. The longer time led to higher content and increased lactic acid content.…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant Activity, Physicochemical Characterisation and Antibacterial Properties of Caspian Sea Yoghurt Enriched with Ginger and Sappanwood Extracts

2023

TJNPR

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Caspian Sea yoghurt has lower acidity and is thicker than common yoghurt. Caspian Sea yoghurt contains probiotic bacteria that improve the balance of intestinal microflora. This research aimed to determine the antioxidant activity of Caspian sea yoghurt enriched with two different herbs, ginger and sappanwood, at concentrations of 5, 10 and 15% w/v. The pH, total phenol, antioxidant, total LAB, and antibacterial activity of the enriched yoghurt were measured to determine the best of the two products. The results showed that the enrichment of the yoghurt with sappanwood and ginger extracts increased lactic acid bacteria (LAB) growth compared with the control (yoghurt without plant extracts). Further analysis showed that the product that contains 15% sappanwood extract was judged to be the best formulation with a pH of 5.01 and a total LAB of 3.78 x 107 CFU/mL. It also exhibited antibacterial activity against B. cereus and E. Coli with zones of inhibition of 8.00 mm and 8.39 mm, respectively. The total phenol content was 5.48 mg GAE/g of the sample and 50.08% antioxidant activity. In conclusion, Caspian sea yoghurt enriched with herbs showed increased antioxidant and antibacterial activities and may have better potential in health maintenance.

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Section: Resultsmentioning

confidence: 99%

“…Total Phenolic content (TPC) was measured using the Follin-Ciocalteu method described by Budiono et al 16 with some modifications. Gallic acid (20 -80 mg/mL) was used to prepare the calibration curve.…”

Section: Measurement Of Total Phenolic Content (Tpc) and Antioxidant ...mentioning

confidence: 99%

Antioxidant Activity, Physicochemical Characterisation and Antibacterial Properties of Caspian Sea Yoghurt Enriched with Ginger and Sappanwood Extracts

2023

TJNPR

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“…scutellaria has been reported to contain various bioactive compounds, which help to increasing breast milk production, including quercetin, kaempferol, rutin, monoterpenes, and triterpenes. (12) Based on an in silico study, these bioactive compounds could interact with dopamine receptor and serotonin receptor which involved during lactogenesis process. P. scutellaria active compounds have an ability to inhibit dopamine D2 receptor and induce serotonin secretion by binding to serotonergic 5-HT2A receptor.…”

Section: Discussionmentioning

confidence: 99%

“…All treatments were given orally for 14 days. (12) Asifit was used as a commercially available positive control drug which is commonly used to increase breast milk production. Asifit contains Sauropus androgynus leaves extract, vitamins B1, B2, B6, and B12.…”

Section: Animal Experimental Designmentioning

confidence: 99%

“…These compounds contribute to their galactagenic properties, making them potentially beneficial for promoting lactation. (12) In this research, further investigation was conducted to examine the impact of P. scutellaria leaf extract on the mammary glands histology, expression of insulin in the mammary gland, as well as plasma insulin and the insulin receptor levels. This analysis aimed to provide a deeper understanding of how P. scutellaria aqueous extract (PSAE) may influence mammary glands histology, insulin production, and insulin signaling pathways, thereby shedding light on its potential mechanisms of action as a galactagogue.…”

Section: Introductionmentioning

confidence: 99%

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Polyscias scutellaria Aqueous Leaves Extract Increases Insulin Levels and Improves Mammary Gland Histology in Lactating Rats

Budiono,

Pertami,

Kasiati

et al. 2023

Indones Biomed J

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BACKGROUND: Exclusive breastfeeding could be a protective step to avoid infant stunting. During lactation, several hormones are involved in milk secretion, including insulin. Polyscias scutellaria is a perennial plant which has traditionally been used to increase breast milk production. This study was conducted to examine the impact of P. scutellaria leaf extract on the mammary gland histology, expression of insulin in the mammary gland, as well as plasma insulin and the insulin receptor levels.METHODS: Five female unmated rats (UR) and twenty female lactating rats were divided into five groups, namely UR, lactating rats only (LRO), lactating rats treated with Asifit (LRA), lactating rats treated with PSAE at a dosage of 250 and 500 mg/kg body weight (BW) (LRPSAE 250 and 500). Treatments were given orally for 14 days. The dams were sacrificed after the weaning stage (third week after parturition), and the serum, mammary gland, liver, and muscle were collected for further analysis.RESULTS: The histoarchitecture of mammary gland between the LRA and LRPSAE groups were similar. The LRPSAE 250 group had higher plasma level and immunofluorescent expression of insulin than the LRA group. PSAE did not affect insulin receptor beta subunit (INSR-β) levels in both liver and muscle of lactating rats.CONCLUSION: PSAE could be used as an herbal treatment to increase breast milk production by improving mammary gland histology and maintaining the mother's insulin levels.KEYWORDS: Polyscias scutellaria, lactating rats, insulin, INSR-β

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Evaluation of antioxidant properties from purple tubers and their ability to improve glucose and lipid metabolism in streptozotocin-induced diabetic rats

Gofur,

Arifah,

Atho'illah

et al. 2024

Phytomedicine Plus

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Lactogenic effect of Polyscias scutellaria extract to maintain postpartum prolactin and oxytocin in lactating rats

Cited by 6 publications

References 39 publications

Antioxidant Activity, Physicochemical Characterisation and Antibacterial Properties of Caspian Sea Yoghurt Enriched with Ginger and Sappanwood Extracts

Antioxidant Activity, Physicochemical Characterisation and Antibacterial Properties of Caspian Sea Yoghurt Enriched with Ginger and Sappanwood Extracts

Polyscias scutellaria Aqueous Leaves Extract Increases Insulin Levels and Improves Mammary Gland Histology in Lactating Rats

Evaluation of antioxidant properties from purple tubers and their ability to improve glucose and lipid metabolism in streptozotocin-induced diabetic rats

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