Lactoferrin protects osteoblasts and osteocytes from apoptosis

Locklin, R M; Hulley, P A; Naot, Dorit; Cornish, Jillian

doi:10.1016/j.bone.2009.03.596

Cited by 1 publication

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“…Recently, there is also a growing interest in the potential use of LF for the improvement of bone health and cancer prevention [6,7]. Further, the exciting potentials of employing nanotechnology in advancing drug delivery systems, active disease targeting and prognosis have also shown some encouraging outcomes.…”

Section: Introductionmentioning

confidence: 99%

Optimization on thermal treatment synthesis of lactoferrin nanoparticles via Taguchi design method

et al. 2019

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Lactoferrin is a globular protein-based biopolymer which has many applications in pharmacy and food industry. In this study, human lactoferrin nanoparticles were synthesized by thermal treatment technique. Taguchi array design was employed to minimize the size of nanoparticles. To gain as this purpose, four main factors with four different levels involved as: lactoferrin concentration (1-4 mg/mL), pH values (6-9), heating rate of (2-5 °C/min) and final temperature of (60-90 °C) were investigated. In the following, prepared nanoparticles were characterized by dynamic light scattering, Fourier transform infrared spectroscopy, scanning electron microscopy, and atomic force microscopy analysis. Analysis of variance showed that lactoferrin concentration with the contribution percentage of 45% is most important in the preparation of nanoparticles. Also, optimal conditions for synthesized nanoparticles by thermal treatment technique were: LF concentration of 3 mg/mL, pH 8, heating rate of 3 °C/min and final temperature of 90 °C to achieve particle size of 188.8 nm, polydispersity index of 0.317 and zeta potential of − 52.2 mV.

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Section: Introductionmentioning

confidence: 99%