Lactoferrin protects against lipopolysaccharide-induced acute lung injury in mice

Lactoferrin suppresses lipopolysaccharide-induced endometritis in mice via down-regulation of the NF-κB pathway

“…Li et al demonstrated that LF had both prophylactic and therapeutic effects on LPS-induced lung tissue damage [14]. This study reported that LF (5 mg/body) was administered by intraperitoneal injection (i.p.)…”

“…A study by Berlutti et al showed that treatment of E. coli-infected Caco-2 cells with LF resulted in reduced expression of pro-inflammatory cytokines such as IL-8 [13]. Li et al demonstrated that intraperitoneal injection of LF in mice with LPS-induced acute lung injury had a protective effect [14]. However, the anti-inflammatory effects of LF on LPS-induced endometritis in mice and the underlying molecular mechanisms remain to be elucidated.…”

A role for whey-derived lactoferrin and immunoglobulins in the attenuation of obesity-related inflammation and disease

“…Lactoferrin, due to its cationic nature, shows high affinity for anionic molecules and is capable of binding LPS, allowing for direct neutralization and limiting activation of macrophage CD14 and other pattern recognition receptors (Legrand et al, 2005) important for initiation of innate immune responses. The LPS-binding abilities of lactoferrin have been reported in various in vitro and animal models using both bovine (Dohler et al, 2002;Pecorini et al, 2010) and human lactoferrin (Zhang et al, 1999;Baveye et al, 2000;Li et al, 2012). In this context, the ability of lactoferrin to prevent LPS-induced inflammatory responses may also play a key role in preventing chronic inflammation mediated by bacterial translocation from the gut, as has been described in obesity (Frazier et al, 2011).…”

Медикаментозне Обмеження Доступності Іонів Заліза Для Патогенних Бактерій (Частина 1)

“…После введения LTF мышам с острым LPS-индуцированным поражением легкого на-блюдается значительное снижение активности ле-гочной миелопероксидазы, концентрации TNF-α и количества иммуноцитов в бронхоальвеолярной лаважной жидкости, а также степени инфильтра-ции воспалительными клетками ткани поражен-ных регионов легкого и выраженности отека ткани легких [33].…”