Lactoferrin promotes the autophagy activity during osteoblast formation via BCL2-Beclin1 signaling

Ke, Dianshan; Wang, Xinwen; Lin, Yinquan; Wei, Shengwang

doi:10.1007/s11033-021-06866-0

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…The antiresorptive effects of LF are due to its capacity to decrease the expression level of RANKL and increase that of OPG (16,33) . The osteogenic effects of lactoferrin could also be explained by its documented capability to increase alkaline phosphatase activity (a marker of bone formation), in a concentration-dependent manner and directly induce osteoblastic autophagy essential for cellular homeostasis (35) .…”

Section: Discussionmentioning

confidence: 99%

The protective effect of Lactoferrin on the alveolar bone loss induced by Carbamazepine in rats

Abdel Fattah,

Hamza

2024

Egyptian Dental Journal

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Introduction: Carbamazepine is one of the widely used anti-epileptic medications associated with elevated fracture rates. Lactoferrin is a secretory glycoprotein with iron binding capacity and one of the transferrin family of proteins. It is naturally found in colostrum and milk in the highest concentrations. It is found to have protective anti-inflammatory, antioxidant, and antimicrobial actions.Aim: This study was designed to evaluate the protective influence of lactoferrin on the alveolar bone damage mediated by carbamazepine in rats. Materials and Methods:Twenty-four healthy female Wistar albino rats were randomly distributed into 3 groups, 8 rats each. Group I-control, rats were given a daily dose of saline. Group II-carbamazepine, rats received carbamazepine 75mg/kg/day orally for 5 weeks. Group IIIcarbamazepine and lactoferrin, rats received carbamazepine 75mg/kg/day in addition to lactoferrin 100 mg/kg/day orally for 5 weeks. After euthanasia, the mandibles of all rats were collected and prepared to be evaluated by light and scanning electron microscopy, histomorphometry, and energydispersive x-ray microanalysis. Results:The alveolar bone in the carbamazepine group showed marked porosity and trabecular thinning in comparison to the control and lactoferrin groups demonstrated by both light and scanning electron microscopy. The bone volume ratio values were significantly higher in carbamazepine-lactoferrin and control groups than in the carbamazepine group. The percentage of calcium mineralization detected by Energy Dispersive X-ray spectroscopy in lactoferrin group was comparable to the control and significantly higher than carbamazepine group.Conclusions: Lactoferrin supplementation could successfully reduce the porosity provoked by anti-epileptic medications in the alveolar bone.

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Section: Discussionmentioning

confidence: 99%

The protective effect of Lactoferrin on the alveolar bone loss induced by Carbamazepine in rats

Abdel Fattah,

Hamza

2024

Egyptian Dental Journal

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“…The expressed product of the Beclin1 gene functions as a subunit of the Class III PI3K complex, which interacts with autophagic precursors to initiate the formation of autophagosomes [ 109 ]. Bcl-2 can bind with Beclin-1 and disrupt the Beclin-1/PI3K complex, which may subsequently block autophagy [ 110 , 111 ]. It is noteworthy that TCTP facilitates the expression of Bcl-2 while leaving the expression of Beclin-1 unaffected.…”

Section: Biological Role Of Tctp In Tumorigenesis and Developmentmentioning

confidence: 99%

Biological role and expression of translationally controlled tumor protein (TCTP) in tumorigenesis and development and its potential for targeted tumor therapy

Liu,

Wang

et al. 2024

Cancer Cell Int

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Translationally controlled tumor protein (TCTP), also known as histamine-releasing factor (HRF) or fortilin, is a highly conserved protein found in various species. To date, multiple studies have demonstrated the crucial role of TCTP in a wide range of cellular pathophysiological processes, including cell proliferation and survival, cell cycle regulation, cell death, as well as cell migration and movement, all of which are major pathogenic mechanisms of tumorigenesis and development. This review aims to provide an in-depth analysis of the functional role of TCTP in tumor initiation and progression, with a particular focus on cell proliferation, cell death, and cell migration. It will highlight the expression and pathological implications of TCTP in various tumor types, summarizing the current prevailing therapeutic strategies that target TCTP.

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Protective Autophagy Attenuates the Cytotoxicity of MTI-31 in Renal Cancer Cells by Activating the ERK Pathway

Zang

Yang

Dai

et al. 2023

Appl Biochem Biotechnol

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Lactoferrin promotes the autophagy activity during osteoblast formation via BCL2-Beclin1 signaling

Cited by 4 publications

References 29 publications

The protective effect of Lactoferrin on the alveolar bone loss induced by Carbamazepine in rats

The protective effect of Lactoferrin on the alveolar bone loss induced by Carbamazepine in rats

Biological role and expression of translationally controlled tumor protein (TCTP) in tumorigenesis and development and its potential for targeted tumor therapy

Protective Autophagy Attenuates the Cytotoxicity of MTI-31 in Renal Cancer Cells by Activating the ERK Pathway

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