Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration

Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer’s disease

“…[15][16][17] These findings suggest that Lf is a suitable ligand to mediate enhanced nose-to-brain delivery of formulations after intranasal administration. [18][19][20] Huperzine A (HupA) is a reversible inhibitor of acetylcholinesterase (AChE) in a club moss (Huperzia serrata), which enhances memory in behavioral animal models. [21][22][23] Studies have shown that HupA exerts multiple neuroprotective effects in addition to inhibition of AChE.…”

Optimised nanoformulation of bromocriptine for direct nose-to-brain delivery: biodistribution, pharmacokinetic and dopamine estimation by ultra-HPLC/mass spectrometry method

“…This may provide significant advantages such as non-invasiveness, bypassing BBB and decreasing systemic drug exposition, thereby reducing systemic side effects as compared to current conventional strategies [6,7]. The drug may be transported directly into the brain tissue (i.e., olfactory bulb) or the cerebrospinal fluid through the olfactory region of the nasal cavity [7,8]. The strategy to achieve improved delivery to the brain would be a combination of a system that specifically targets the olfactory region and bioadhesive characteristic that retains the formulation at the absorption site for prolonged period of time and improves drug delivery [9].…”

Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson’s disease treatment

“…As shown in Figure 8A, plasma concentration-time curves of Lf-NPs and NPs had similar trends, which suggested that the Lf modification on the surface of NPs did not impair the long circulation time of PEG. 22 After intranasal administration of rotigotine NPs/Lf-NPs, the concentration of rotigotine was much higher in the striatum than in plasma, and the area under the concentration-time curve for 0-8 h (AUC 0-8 h ) for NPs and Lf-NPs was 1.44-and 1.89-fold higher in the striatum compared with that in the plasma, indicating that intranasal administration may contribute to more efficient brain drug delivery. (B) ex vivo imaging of organs excised from mice at 4 h after intranasal administration.…”

“…21,22 The products were purified via a Sephadex G25 column. The quantity of introduced thiol groups was measured by ultraviolet (UV) spectrophotometry (λ=412 nm) (Metash Instruments Co, Ltd, Shanghai, People's Republic of China) with Ellmann's reagent.…”