Lactoferrin in Sjögren's Syndrome

Abstract

The concentration of lactoferrin (LF) in unstimulated mixed saliva in Sjogren's syndrome assayed by a double-antibody solid-phase radioimmunoassay was 16.28 * 3.05 pg/mg of protein (range 7.42-33.64) and differed significantly (P < 0.001) from that of normal control subjects matched for sex and age (2.82 * 0.80 pglmg of protein, range 0. 59-7.35). An unlabeled antibody-enzyme (peroxidase-antiperoxidase) method for labial salivary gland biopsies optimally fixed in Carnoy's fluid yielded strong staining of LF in intralobular and interlobular ducts, whereas only weak staining was observed in the serous secretory units of these mixed glands; this contrasted to the LF distribution in normal salivary glands. The results indicate that the

Lactoferrin, amylase and mucin MUC5B and their relation to the oral microflora in hyposalivation of different origins

“…An increase in the lactoferrin concentration in saliva from the parotid gland was found by Jezequel et al (20) and by Konttinen et al (21). However, there are conflicting results when it comes to the correlation between the lactoferrin concentration in stimulated parotid saliva and the degree of inflammation in the salivary glands (20, 21). We think it is reasonable to believe that part of the lactoferrin in the primary Sjögren’s syndrome group comes from the inflamed salivary glands and the rest from leakage through disrupted fragile mucosal membranes due to a longstanding low salivary secretion rate.…”

“…2). Konttinen et al (21) found a similar increase in lactoferrin concentration in unstimulated whole saliva. An increase in the lactoferrin concentration in saliva from the parotid gland was found by Jezequel et al (20) and by Konttinen et al (21).…”

“…Konttinen et al (21) found a similar increase in lactoferrin concentration in unstimulated whole saliva. An increase in the lactoferrin concentration in saliva from the parotid gland was found by Jezequel et al (20) and by Konttinen et al (21). However, there are conflicting results when it comes to the correlation between the lactoferrin concentration in stimulated parotid saliva and the degree of inflammation in the salivary glands (20, 21).…”

Localization of antimicrobial peptides human β‐defensins in minor salivary glands with Sjögren’s syndrome

“…These results suggest that a reduction in salivary gland HBD-2 expression occurs earlier than that of HBD-1 during the progression of SS, even though histological differences were not found. The expression of lactoferrin, an antimicrobial protein, was found to be increased in labial glands of subjects with SS (19). This indicates that SS might cause dysfunction to the production of antimicrobial substance.…”

“…The expression of lactoferrin, an antimicrobial protein, was found to be increased in labial glands of subjects with SS (19). This indicates that SS might cause dysfunction to the production of antimicrobial substance.…”