Lactoferrin in milk from different species

Masson, Pierre; Heremans, J. F.

doi:10.1016/0305-0491(71)90258-6

Cited by 294 publications

(182 citation statements)

References 31 publications

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“…In adults, higher levels of lactoferrin are present in milk and colostrum (Masson and Heremans, 1971;Brock, 1980). It is also found in most mucosal secretions such as uterine fluid, vaginal secretion, seminal fluid, saliva, bile, pancreatic juice, small intestine secretions, nasal secretion, and tears (Masson et al, 1966;Baker, 1994;Levay and Viljoen, 1995;Lonnerdal and Iyer, 1995;Kikuchi et al, 2003;Baker and Baker, 2005).…”

Section: Sources Of Lactoferrin In the Organismmentioning

confidence: 99%

Lactoferrin: a review

Adlerova¹,

Bartošková²,

Faldyna³

2008

Vet. Med. - Czech

257

215

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This review discusses the biological properties of the glycoprotein lactoferrin. Lactoferrin has been identified in secretions from exocrine glands and in specific granules of neutrophils. After degranulation, neutrophils become the main source of lactoferrin in blood plasma. Lactoferrin possesses various biological functions, including roles in iron metabolism, cell proliferation and differentiation, and antibacterial, antiviral, and antiparasitic activity. Many of these functions do not appear to be connected with its iron binding ability. Of late, lactoferrin concentrations have been measured mostly in humans but also in some other species. However, the relationship between its concentration and physiological or pathological effects on body functions is not yet well characterised.

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Section: Sources Of Lactoferrin In the Organismmentioning

confidence: 99%

Lactoferrin: a review

Adlerova¹,

Bartošková²,

Faldyna³

2008

Vet. Med. - Czech

257

215

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“…Masson and Heremans [16] when studying ten different mammalian species reported the highest levels of LF in human breast milk. In human milk, the highest level is found in the colostrum (7 mg/mL) and 1 mg/ml in mature milk.…”

Section: Sourcementioning

confidence: 97%

“…In human milk, the highest level is found in the colostrum (7 mg/mL) and 1 mg/ml in mature milk. This fall in concentration of LF is slow in preterm mother's milk [16][17][18].…”

Section: Sourcementioning

confidence: 99%

Lactoferrin and Its Role in Neonatology: A Review Article

Sharma¹

2015

JPNC

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Lactoferrin (LF) is a glycoprotein, which is present in milk of mammals. It has been proven to plays a very important role in innate immune host defences. It is well known that Neonatal sepsis and necrotizing enterocolitis (NEC) are responsible for significant morbidity and mortality in the new-born, especially in VLBW (1500 grams at birth) infants. The ill effects of sepsis and NEC persist in spite of appropriate and effective antibiotic therapy and have been associated with poor long term outcome. In the few recent trials which have been conducted around the globe, in field of neonatology, role of LF in prevention of neonatal sepsis and NEC has been strengthened. Furthermore many trials are underway and only future may provide a definite answer of LF role in sepsis and NEC. This review article has been written to through some light on the recent work that has already been done, to strengthen the role of LF in neonatal sepsis and the work that is still under process.

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“…Bunlardan başka laktoferrin heterofilik lökosit granüllerinde yoğun olarak bulunmaktadır (3,11). Laktoferrin plazmada da bulunmasına karşın miktarı süttekine oranla önemli ölçüde düşük seviyededir (9).…”

Section: Introductionunclassified

“…Süt laktoferrin seviyesi düşük olan türlerde ise süt transferrin seviyesi yüksektir. Böylece sütteki Fe miktarına bağlı olarak birçok farklı türün sütünde hem transferrin hem de laktoferrinin birlikte bulunduğu görülmektedir (11).…”

Section: Introductionunclassified

Laktasyon periyodundaki Ankara keçilerinde süt ve serum laktoferrin düzeyleri

Gülcan¹

2004

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Özet: Ankara keçilerindeki laktoferrinin süt ve kan serum düzeyleri laktasyon periyodu boyunca ELISA ile belirlenmiş ve süt serumu ile kan serum proteinleri poliakrilamid jel elektroforezde incelenmiştir. Toplam 18 baş Ankara keçisinden laktasyonun 1., 2., 3., 5., 7., 11., 15., 20., 30., 45. ve 60. günlerinde süt ve kan örnekleri alınmıştır. Mastitis indikatör kağıt ile kontrol edilen süt numunelerinde direk somatik hücre sayımı yapılmıştır. Kesilmiş süt proteinleriyle kan serum proteinlerinin % dağılımları poliakrilamid jel elektroforezde incelenmiştir. Elektroforez bantlarının değerlendirilmesinde yaklaşık 78.000 dalton molekül ağırlığındaki proteinin süt serumundaki dansitometrik % dağılımı laktasyonun başlangıcında daha düşükken, laktasyon periyodu boyunca giderek artmış ve 2 katı seviyesine ulaşmıştır. Elektroforez bantlarının değerlendirilmesinde yaklaşık 78.000 dalton molekül ağırlığındaki serum proteininin dansitometrik % dağılımı, ilk üç gün istatistik olarak laktasyonun diğer günlerine göre yüksek bulunmuştur. Laktasyonun 3. gününden itibaren ise giderek azalan bir % dağılım göstermiştir. Süt ve serumdaki laktoferrin düzeyleri ELISA ile belirlenmiştir. Laktasyon süresince süt ve serum laktoferrin miktarları ELISA yönteminde sırasıyla ortalama 39.43-63.97 µg/ml ve 2.17-3.08 µg/ml arasında değişim göstermiştir. Ankara keçilerinde süt ve serum laktoferrin düzeyleri laktasyon periyodu boyunca istatistik olarak önemli bir değişim göstermemiştir. Tiftik verimi yönüyle yetiştirilen Ankara keçilerinde süt ve serum laktoferrin düzeyleri literatür verilerindeki domuz, inek, köpek, koyun ve keçi gibi laktasyondaki diğer hayvanların süt ve serum laktoferrin düzeylerine göre çok düşük bulunmuştur.Anahtar sözcükler: Ankara keçisi, demir bağlayan glikoprotein, laktoferrin, süt proteinleriMilk and serum lactoferrin levels in Angora Goats during lactation period Summary: Milk and serum lactoferrin levels which is important for human and animal healt because of its several properties during lactation period in Angora Goats were determined. Milk and blood samples have been taken from 18 Angora Goats in 1 st , 2 nd , 3 rd , 5 th , 7 th , 11 th , 15 th , 20 th , 30 th , 45 th and 60 th days of lactation. In milk samples, somatic cell counts have been performed following the control of milk samples using indicator papers for mastitis. Fat and casein were removed from milk samples by centrifugation and using glacial acetic acit precipitation respectively. Following that proteins were precipitated from milk serum by amonium sulphate precipitation. Obtained whey proteins of milk and blood serum proteins were applied to Polyaccrilamide Gel Electrophoresis (SDS-PAGE) system. Milk and serum lactoferrin levels were detected using ELISA. Dansitometric analysis of whey protein bands on the gels showed that a protein with approximately 78.000 dalton molecular weight showed a decreased percentage at the beginning of lactation. This 78.000 dalton protein was gradually increased towards the end of lactation up to the two fold increase. ...

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Lactoferrin in milk from different species

Cited by 294 publications

References 31 publications

Lactoferrin: a review

Lactoferrin: a review

Lactoferrin and Its Role in Neonatology: A Review Article

Laktasyon periyodundaki Ankara keçilerinde süt ve serum laktoferrin düzeyleri

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