Lactoferrin for COVID-19 prevention, treatment, and recovery

Bolat, Ecem; Eker, Furkan; Kaplan, Merve; Duman, Hatice; Arslan, Ayşenur; Sarıtaş, Sümeyye; Şahutoğlu, Arif Sercan; Karav, Sercan

doi:10.3389/fnut.2022.992733

Cited by 26 publications

(14 citation statements)

References 99 publications

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“…LTF improves neurological deficits associated with stroke (62). Accumulating evidence has revealed the potential applications of LFT in the COVID-19 management (63)(64)(65). Targeting LTF may be a treatment strategy for COVID-19 and IS.…”

Section: Discussionmentioning

confidence: 99%

Investigation of shared genes and regulatory mechanisms associated with coronavirus disease 2019 and ischemic stroke

Han

2023

Front. Neurol.

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ObjectiveClinical associations between coronavirus disease (COVID-19) and ischemic stroke (IS) have been reported. This study aimed to investigate the shared genes between COVID-19 and IS and explore their regulatory mechanisms.MethodsPublished datasets for COVID-19 and IS were downloaded. Common differentially expressed genes (DEGs) in the two diseases were identified, followed by protein–protein interaction (PPI) network analysis. Moreover, overlapping module genes associated with the two diseases were investigated using weighted correlation network analysis (WGCNA). Through intersection analysis of PPI cluster genes and overlapping module genes, hub-shared genes associated with the two diseases were obtained, followed by functional enrichment analysis and external dataset validation. Moreover, the upstream miRNAs and transcription factors (TFs) of the hub-shared genes were predicted.ResultsA total of 91 common DEGs were identified from the clusters of the PPI network, and 129 overlapping module genes were screened using WGCNA. Based on further intersection analysis, four hub-shared genes in IS and COVID-19 were identified, including PDE5A, ITGB3, CEACAM8, and BPI. These hub-shared genes were remarkably enriched in pathways such as ECM-receptor interaction and focal adhesion pathways. Moreover, ITGB3, PDE5A, and CEACAM8 were targeted by 53, 32, and 3 miRNAs, respectively, and these miRNAs were also enriched in the aforementioned pathways. Furthermore, TFs, such as lactoferrin, demonstrated a stronger predicted correlation with the hub-shared genes.ConclusionThe four identified hub-shared genes may participate in crucial mechanisms underlying both COVID-19 and IS and may exhibit the potential to be biomarkers or therapeutic targets for the two diseases.

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Section: Discussionmentioning

confidence: 99%

Investigation of shared genes and regulatory mechanisms associated with coronavirus disease 2019 and ischemic stroke

Han

2023

Front. Neurol.

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“…It has antibacterial, antiviral, antifungal, antiparasitic, and anti-inflammatory properties, as well as being implicated in innate and adaptive immune modulation ( 42 , 43 ). Lf has antiviral activity against DNA and RNA viruses ( 44 , 45 ), and the exact mechanism of its activity against bacterial and viral infections has been highlighted for the prevention of diseases ( 46 ).…”

Section: The Main Immunomodulating and Bioactive Components Of Bovine...mentioning

confidence: 99%

Bovine colostrum and its potential contributions for treatment and prevention of COVID-19

Duman,

Karav

2023

Front. Immunol.

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Bovine colostrum (BC) is the initial milk an animal produces after giving birth, particularly in the first few days. Numerous bioactive substances found in BC, including proteins, enzymes, growth factors, immunoglobulins, etc., are beneficial to human health. BC has a significant role to play as part of a healthy diet, with well-documented health and nutritional advantages for people. Therefore, the use of BC and its crucial derivatives in the development of functional food and pharmaceuticals for the prevention of several diseases such as gastrointestinal and respiratory system disorders is becoming increasingly popular around the world. A novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of a cluster of pneumonia cases that is called Coronavirus Disease 2019 (COVID-19) in China. After the first SARS-CoV-2 virus-related fatality was announced, the illness quickly spread throughout China and to other continents, causing a pandemic. Since then, numerous studies have been initiated to develop safe and efficient treatments. To prevent viral infection and potential lingering effects, it is important to investigate alternative treatments for COVID-19. Due to its effective bioactive profile and its immunomodulatory roles in biological processes, BC might be considered a promising approach to assist in combating people affected by the SARS-CoV-2 or prevention from the virus. BC has immunomodulatory effects because to its high concentration of bioactive components such as immunoglobulins, lactoferrin, cytokines, and growth factors, etc., which might help control immunological responses, potentially fostering a balanced immune response. Furthermore, its bioactive components have a potential cross-reactivity against SARS-CoV-2, aiding in virus neutralization and its comprehensive food profile also supplies important vitamins, minerals, and amino acids, fostering a healthy immune system. Hence, the possible contributions of BC to the management of COVID-19 were reviewed in this article based on the most recent research on the subject. Additionally, the key BC components that influence immune system modulation were evaluated. These components may serve as potential mediators or therapeutic advantages in COVID-19.

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“…Besides, immunomodulatory drugs such as lactoferrin is used to control inflammatory responses in their respective auto-immune conditions, which was demonstrated its effects and mechanisms in the prevention, treatment, and recovery for COVID-19 ( 9 ). A clinic trial of lactoferrin suggested that, the COVID-19 patients who were given lactoferrin every day for 10 days, had shown a positive effect and all patients had a faster recovery when compared with the control group ( 10 ). Furthermore, traditional Chinese medicine (TCM) was also exerted the prevention and treatment in regulating immunity and inflammation during the outbreak of COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Boosting the immunogenicity of the CoronaVac SARS-CoV-2 inactivated vaccine with Huoxiang Suling Shuanghua Decoction: a randomized, double-blind, placebo-controlled study

Tang,

Wang,

Zhang

et al. 2024

Front. Immunol.

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IntroductionIn light of the public health burden of the COVID-19 pandemic, boosting the safety and immunogenicity of COVID-19 vaccines is of great concern. Numerous Traditional Chinese medicine (TCM) preparations have shown to beneficially modulate immunity. Based on pilot experiments in mice that showed that supplementation with Huoxiang Suling Shuanghua Decoction (HSSD) significantly enhances serum anti-RBD IgG titers after inoculation with recombinant SARS-CoV-2 S-RBD protein, we conducted this randomized, double-blind, placebo-controlled clinical trial aimed to evaluate the potential immunogenicity boosting effect of oral HSSD after a third homologous immunization with Sinovac’s CoronaVac SARS-CoV-2 (CVS) inactivated vaccine.MethodsA total of 70 participants were randomly assigned (1:1 ratio) to receive a third dose of CVS vaccination and either oral placebo or oral HSSD for 7 days. Safety aspects were assessed by recording local and systemic adverse events, and by blood and urine biochemistry and liver and kidney function tests. Main outcomes evaluated included serum anti-RBD IgG titer, T lymphocyte subsets, serum IgG and IgM levels, complement components (C3 and C4), and serum cytokines (IL-6 and IFN-γ). In addition, metabolomics technology was used to analyze differential metabolite expression after supplementation with HSSD.ResultsFollowing a third CVS vaccination, significantly increased serum anti-RBD IgG titer, reduced serum IL-6 levels, increased serum IgG, IgM, and C3 and C4 levels, and improved cellular immunity, evidenced by reduce balance deviations in the distribution of lymphocyte subsets, was observed in the HSSD group compared with the placebo group. No serious adverse events were recorded in either group. Serum metabolomics results suggested that the mechanisms by which HSSD boosted the immunogenicity of the CVS vaccine are related to differential regulation of purine metabolism, vitamin B6 metabolism, folate biosynthesis, arginine and proline metabolism, and steroid hormone biosynthesis.ConclusionOral HSSD boosts the immunogenicity of the CVS vaccine in young and adult individuals. This trial provides clinical reference for evaluation of TCM immunomodulators to improve the immune response to COVID-19 vaccines.

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Lactoferrin for COVID-19 prevention, treatment, and recovery

Cited by 26 publications

References 99 publications

Investigation of shared genes and regulatory mechanisms associated with coronavirus disease 2019 and ischemic stroke

Investigation of shared genes and regulatory mechanisms associated with coronavirus disease 2019 and ischemic stroke

Bovine colostrum and its potential contributions for treatment and prevention of COVID-19

Boosting the immunogenicity of the CoronaVac SARS-CoV-2 inactivated vaccine with Huoxiang Suling Shuanghua Decoction: a randomized, double-blind, placebo-controlled study

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