Lactoferrin: Antimicrobial impacts, genomic guardian, therapeutic uses and clinical significance for humans and animals

El‐Hack, Mohamed E. Abd; Abdelnour, Sameh A.; Kamal, Mahmoud; Khafaga, Asmaa F.; Shakoori, Afnan M.; Bagadood, Rehab M.; Naffadi, Hind M.; Alyahyawi, Areej Y.; Khojah, Hanan; Alghamdi, Saleh; Jaremko, Mariusz; Świątkiewicz, Sylwester

doi:10.1016/j.biopha.2023.114967

Cited by 7 publications

(2 citation statements)

References 104 publications

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“…Analyzing data from lactoferrin studies in both rats [73] and humans [74][75][76][77], as well as talactoferrin [78] studies in humans, indicates that LfcinB can be classified as biologically safe. There were no reported hematological, hepatic, or renal toxicities during therapy.…”

Section: Antileukemic Selectivity and Low Potential Toxicitymentioning

confidence: 99%

Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity

Lica,

Gucwa,

Heldt

et al. 2024

Molecules

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The fusion of penetrating peptides (PPs), e.g., cell penetration peptides (CPPs) or antimicrobial peptides (AMPs), together with antimicrobial agents is an expanding research field. Specific AMPs, such as lactoferricin B (LfcinB), have demonstrated strong antibacterial, antifungal, and antiparasitic activity, as well as valuable anticancer activity, proving beneficial in the development of anticancer conjugates. The resulting conjugates offer potential dual functionality, acting as both an anticancer and an antimicrobial agent. This is especially necessary in cancer treatment, where microbial infections pose a critical risk. Leukemic cells frequently exhibit altered outer lipid membranes compared to healthy cells, making them more sensitive to compounds that interfere with their membrane. In this study, we revisited and reanalyzed our earlier research on LfcinB and its conjugates. Furthermore, we carried out new experiments with a specific focus on cell proliferation, changes in membrane asymmetric phosphatidylserine location, intracellular reactive oxygen species (ROS) generation, mitochondrial functions, and in vitro bacterial topoisomerase inhibition.

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Section: Antileukemic Selectivity and Low Potential Toxicitymentioning

confidence: 99%

Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity

Lica,

Gucwa,

Heldt

et al. 2024

Molecules

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“…As LF is present in biological fluids, it lowers the iron concentration in these fluids upon infection and destabilizes the membrane of pathogens. Moreover, in our body, many proteins help regulate iron, but LF is the only regulator that acts as the first line of defense against pathogens entering the body through the mucosa ( 46 , 47 ). In addition, the hepatic production of LF is increased by IFN-γ, TNF-α, and IL-6 in response to infection that results in the sequestration of extracellular iron, as shown in Figure 2 ( 11 ).…”

Section: Host Iron Regulation During Pathogen Attackmentioning

confidence: 99%

Key players in the regulation of iron homeostasis at the host-pathogen interface

Ullah,

Lang

2023

Front. Immunol.

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Iron plays a crucial role in the biochemistry and development of nearly all living organisms. Iron starvation of pathogens during infection is a striking feature utilized by a host to quell infection. In mammals and some other animals, iron is essentially obtained from diet and recycled from erythrocytes. Free iron is cytotoxic and is readily available to invading pathogens. During infection, most pathogens utilize host iron for their survival. Therefore, to ensure limited free iron, the host’s natural system denies this metal in a process termed nutritional immunity. In this fierce battle for iron, hosts win over some pathogens, but others have evolved mechanisms to overdrive the host barriers. Production of siderophores, heme iron thievery, and direct binding of transferrin and lactoferrin to bacterial receptors are some of the pathogens’ successful strategies which are highlighted in this review. The intricate interplay between hosts and pathogens in iron alteration systems is crucial for understanding host defense mechanisms and pathogen virulence. This review aims to elucidate the current understanding of host and pathogen iron alteration systems and propose future research directions to enhance our knowledge in this field.

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Lactoferrin: Current situation and future prospects

Hu,

Shen,

Xia

et al. 2024

Food Bioscience

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Lactoferrin: Antimicrobial impacts, genomic guardian, therapeutic uses and clinical significance for humans and animals

Cited by 7 publications

References 104 publications

Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity

Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity

Key players in the regulation of iron homeostasis at the host-pathogen interface

Lactoferrin: Current situation and future prospects

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