Lactoferrin alleviates Western diet-induced cognitive impairment through the microbiome-gut-brain axis

He, Qian; Zhang, Lili; Liu, Deming; Wu, Jiangxue; Guo, Yaxin; Fan, Jing; Wu, Qingping; Wang, Haipeng; Wan, Zhongxiao; Xu, Jia‐Ying; Qin, Li–Qiang

doi:10.1016/j.crfs.2023.100533

Cited by 4 publications

(1 citation statement)

References 65 publications

(85 reference statements)

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“…Studies also showed the potential of native and iron-saturated bovine lactoferrin in restoring the normal levels of some anti-inflammatory bacteria (i.e., Bacteroidaceae , Prevotellaceae and Rikenellaceae ) in a mouse model of antibiotic-induced dysbiosis [ 149 ]. In addition, a recent study demonstrated a role of lactoferrin in alleviating cognitive impairment in western-diet induced obese mice by improving the gut-microbiota-brain axis, mainly inducing an increase in Bacteroidetes (i.e., Roseburia ), which led to an inhibition of microglial activation and neuroinflammation [ 150 ].…”

Section: Prebiotic Activity Of Whey Proteinsmentioning

confidence: 99%

Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides

Gallo,

Arienzo,

Tomassetti

et al. 2024

Foods

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A strong correlation between the occurrence of various pathological conditions and intestinal dysbiosis is supported by a range of strong evidence. Vice versa, many pathologies have been shown, in turn, to be responsible for alterations in the gut microbiota, a condition that can worsen illness outcomes and response to therapies. For these reasons, great efforts have been made, and studies are still ongoing, to elucidate the mechanisms underlying gut microbiota alterations and to search for pharmacologic or other strategies that can effectively restore the gut microbiota. In this narrative review, we examined the most significant literature on the role of some milk bioactive compounds, such as milk oligosaccharides and whey proteins, in modulating the composition of the gut microbiota and the underlying mechanisms of action, with the aim of investigating the impact of the microbiota changes mediated by these milk bioactive molecules on human health, and their potential use as therapeutics to treat or adjuvate the treatment of gut dysbiosis and associated pathologies.

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Section: Prebiotic Activity Of Whey Proteinsmentioning

confidence: 99%

Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides

Gallo,

Arienzo,

Tomassetti

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

Unlocking the power of Lactoferrin: Exploring its role in early life and its preventive potential for adult chronic diseases

Wang,

An,

Huang

et al. 2024

Food Research International

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Gut microbiota in multiple sclerosis and animal models

Schumacher,

Doyle,

Hill

et al. 2024

The FEBS Journal

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Multiple sclerosis (MS) is a chronic central nervous system (CNS) neurodegenerative and neuroinflammatory disease marked by a host immune reaction that targets and destroys the neuronal myelin sheath. MS and correlating animal disease models show comorbidities, including intestinal barrier disruption and alterations of the commensal microbiome. It is accepted that diet plays a crucial role in shaping the microbiota composition and overall gastrointestinal (GI) tract health, suggesting an interplay between nutrition and neuroinflammation via the gut‐brain axis. Unfortunately, poor host health and diet lead to microbiota modifications that could lead to significant responses in the host, including inflammation and neurobehavioral changes. Beneficial microbial metabolites are essential for host homeostasis and inflammation control. This review will highlight the importance of the gut microbiota in the context of host inflammatory responses in MS and MS animal models. Additionally, microbial community restoration and how it affects MS and GI barrier integrity will be discussed.

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Lactoferrin alleviates Western diet-induced cognitive impairment through the microbiome-gut-brain axis

Cited by 4 publications

References 65 publications

Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides

Milk Bioactive Compounds and Gut Microbiota Modulation: The Role of Whey Proteins and Milk Oligosaccharides

Unlocking the power of Lactoferrin: Exploring its role in early life and its preventive potential for adult chronic diseases

Gut microbiota in multiple sclerosis and animal models

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