2012
DOI: 10.1016/j.bbagen.2011.06.018
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Lactoferrin a multiple bioactive protein: An overview

Abstract: The large potential applications of Lf have led scientists to develop this nutraceutical protein for use in feed, food and pharmaceutical applications. This article is part of a Special Issue entitled Molecular Mechanisms of Iron Transport and Disorders.

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Cited by 381 publications
(313 citation statements)
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“…Lf exhibits pleiotropic biological properties, such as a role in iron homeostasis, in the immune response, in the prevention of tumorigenesis, as well as in anti-inflammatory processes (for review, see ref. 10). Interestingly, this functional nutrient was recently shown to reduce the incidence of late-onset bacterial and fungal sepsis in low-birth-weight neonates (11).…”
mentioning
confidence: 99%
“…Lf exhibits pleiotropic biological properties, such as a role in iron homeostasis, in the immune response, in the prevention of tumorigenesis, as well as in anti-inflammatory processes (for review, see ref. 10). Interestingly, this functional nutrient was recently shown to reduce the incidence of late-onset bacterial and fungal sepsis in low-birth-weight neonates (11).…”
mentioning
confidence: 99%
“…Bovine lactoferrin (bLF) is an iron-binding glycoprotein that belongs to the transferrin family and is produced by epithelial cells of the exocrine glands [1,2] . bLF can stimulate the proliferation and differentiation of bone-forming osteoblasts and act as a survival factor for these cells [3] .…”
Section: Introductionmentioning
confidence: 99%
“…Lactoferrin is an iron-binding glycoprotein that links to free iron in the saliva, causing bactericidal or bacteriostatic effects on various microorganisms requiring iron for their survival. Lactoferrin also provides fungicidal, antiviral, anti-inflammatory, and immunomodulatory functions [31][32][33]. The lactoperoxidase-thiocyanate system in saliva has been shown to be bactericidal on some strains of Lactobacillus and Streptococcus by preventing the accumulation of lysine and glutamic acid, both of which being essential for bacterial growth [34,35].…”
Section: Host Defense Mechanismsmentioning
confidence: 99%