Lactoferrin a multiple bioactive protein: An overview

García-Montoya, Isui Abril; Siqueiros-Cendón, Tania; Arévalo-Gallegos, Sigifredo; Rascón-Cruz, Quintín

doi:10.1016/j.bbagen.2011.06.018

Cited by 364 publications

(290 citation statements)

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“…Lf exhibits pleiotropic biological properties, such as a role in iron homeostasis, in the immune response, in the prevention of tumorigenesis, as well as in anti-inflammatory processes (for review, see ref. 10). Interestingly, this functional nutrient was recently shown to reduce the incidence of late-onset bacterial and fungal sepsis in low-birth-weight neonates (11).…”

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confidence: 99%

Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

et al. 2013

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Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf ) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementation with bLf on IUGR-induced sequelae, including inadequate growth and altered cerebral development, remains unknown. Methods: IUGR was induced through maternal dexamethasone infusion (100 μg/kg during last gestational week) in rats. Maternal supplementation with bLf (0.85% in food pellet) was provided during both gestation and lactation. Pups growth was monitored, and pup brain metabolism and gene expression were studied using in vivo 1 H NMR spectroscopy, quantitative PCR, and microarray in the hippocampus at postnatal day (PND)7. results: Maternal bLf supplementation did not change gestational weight but increased the birth body weight of control pup (4%) with no effect on the IUGR pups. Maternal bLf supplementation allowed IUGR pups to recover a normalized weight at PND21 (weaning) improving catch-up growth. Significantly altered levels of brain metabolites (γ-aminobutyric acid, glutamate, N-acetylaspartate, and N-acetylaspartylglutamate) and transcripts (brain-derived neurotrophic factor (BDNF), divalent metal transporter 1 (DMT-1), and glutamate receptors) in IUGR pups were normalized with maternal bLf supplementation. conclusion: Our data suggest that maternal bLf supplementation is a beneficial nutritional intervention able to revert some of the IUGR-induced sequelae, including brain hippocampal changes.

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Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

et al. 2013

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“…Bovine lactoferrin (bLF) is an iron-binding glycoprotein that belongs to the transferrin family and is produced by epithelial cells of the exocrine glands [1,2] . bLF can stimulate the proliferation and differentiation of bone-forming osteoblasts and act as a survival factor for these cells [3] .…”

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Lactoferrin inhibits apoptosis through insulin-like growth factor I in primary rat osteoblasts

et al. 2014

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“…Lactoferrin is an iron-binding glycoprotein that links to free iron in the saliva, causing bactericidal or bacteriostatic effects on various microorganisms requiring iron for their survival. Lactoferrin also provides fungicidal, antiviral, anti-inflammatory, and immunomodulatory functions [31][32][33]. The lactoperoxidase-thiocyanate system in saliva has been shown to be bactericidal on some strains of Lactobacillus and Streptococcus by preventing the accumulation of lysine and glutamic acid, both of which being essential for bacterial growth [34,35].…”

Section: Host Defense Mechanismsmentioning

confidence: 99%

Impact of Dental Plaque Biofilms in Periodontal Disease: Management and Future Therapy

Lazăr¹,

Dițu²,

Curuţiu³

et al. 2017

Periodontitis - A Useful Reference

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Oral cavity represents an ideal environment for the microbial cell growth, persistence, and dental plaque establishment. The presence of different microniches leads to the occurrence of different biofilm communities, formed on teeth surface, above gingival crevice or at subgingival level, on tongue, mucosa and dental prosthetics too. The healthy state is regulated by host immune system and interactions between microbial community members, maintaining the predominance of "good" microorganisms. When the complexity and volume of biofilms from the gingival crevice increase, chronic pathological conditions such as gingivitis and periodontitis can occur, predisposing to a wide range of complications. Bacteria growing in biofilms exhibit a different behavior compared with their counterpart, respectively planktonic or free cells. There have been described numerous mechanisms of differences in antibiotic susceptibility of biofilm embedded cells. Resistance to antibiotics, mediated by genetic factors or, phenotypical, due to biofilm formation, called also tolerance, is the most important cause of therapy failure of biofilm-associated infections, including periodontitis; the mechanisms of tolerance are different, the metabolic low rate and cell's dormancy being the major ones. The recent progress in science and technology has made possible a wide range of novel approaches and advanced therapies, aiming the efficient management of periodontal disease.

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Lactoferrin a multiple bioactive protein: An overview

Abstract: The large potential applications of Lf have led scientists to develop this nutraceutical protein for use in feed, food and pharmaceutical applications. This article is part of a Special Issue entitled Molecular Mechanisms of Iron Transport and Disorders.

Cited by 364 publications

References 216 publications

Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

Lactoferrin inhibits apoptosis through insulin-like growth factor I in primary rat osteoblasts

Impact of Dental Plaque Biofilms in Periodontal Disease: Management and Future Therapy

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