Lactococcus lactis Strain Plasma Improves Subjective Physical State and Presenteeism: A Randomized, Open-Label Crossover Study among Healthy Office Workers

Kokubo, Takeshi; Wakai, Shimpei; Fujiwara, Daisuke; Kanauchi, Osamu; Jounai, Kenta; Ichikawa, Hisahiro; Takuma, Mihoko; Kanaya, Yoshihisa; Shiraoka, Ryohei

doi:10.3746/pnf.2020.25.2.140

Cited by 3 publications

(24 citation statements)

References 15 publications

(30 reference statements)

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“…Although the mechanism of HHV-6 and HHV-7 reactivations in the salivary glands has not been clarified, salivary shedding of these viruses has been associated with fatigue and depression [ 14 , 35 ]. Meanwhile, several studies have suggested that LC-Plasma intake can decrease fatigue during consecutive high-intensity exercise sessions in young male athletes [ 22 ] and improve work performance [ 21 ]. In addition to the effect of LC-Plasma on viral reactivation, analysis of its effects on physical and mental changes is also important for future experiments.…”

Section: Discussionmentioning

confidence: 99%

“…Mouse experiments showed that LC-Plasma intake suppresses respiratory [18], Microorganisms 2021, 9, 1683 2 of 9 mucosal [19], and systemic viral infections [20]. In addition, health economic analysis has shown that LC-Plasma confers economic benefits by improving worker productivity [21]. Moreover, LC-Plasma decreases fatigue accumulation during high-intensity exercise in male athletes [22].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Lactococcus lactis Strain Plasma on HHV-6 and HHV-7 Shedding in Saliva: A Prospective Observational Study

et al. 2021

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HHV-6 and HHV-7 can reactivate in the salivary gland in response to various host stresses. Lactococcus lactis strain Plasma (LC-Plasma) can activate plasmacytoid dendritic cells (pDCs) and decrease viral infection. We investigated whether LC-Plasma intake could decrease HHV-6 and HHV-7 reactivation in the salivary gland. A total of 54 healthy volunteers were enrolled in this study. Participants took LC-Plasma granules daily for 6 weeks. Saliva samples were collected from subjects weekly for 4 weeks before (first), during (second), and after (third period) LC-Plasma intake. There was a 2-week interval between the first and second periods and a 3-week interval between the second and third periods. Mean salivary HHV-6 and HHV-7 DNA loads were compared among the three observation periods. In the first period (baseline data of viral DNA shedding), HHV-6 DNA shedding was significantly higher in subjects under 40 years old, and HHV-7 DNA shedding was significantly higher in males. HHV-6 and HHV-7 DNA loads did not significantly differ between periods. Meanwhile, in a subgroup analysis of the subjects under 40 years old, HHV-6 DNA load was significantly lower in the second period than in the first period. LC-Plasma decreases HHV-6 reactivation in the salivary glands in younger adults.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Lactococcus lactis Strain Plasma on HHV-6 and HHV-7 Shedding in Saliva: A Prospective Observational Study

et al. 2021

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“…As summarized in Table 4, the stress-related health outcomes measured varied widely, but we identified four primary areas of investigation: (1) stress biomarkers, Twice a day Guillemard/2010 34 Kalima/2016 35 Kinoshita/2019 41 Kinoshita/2021 47 Kokubo/2020 42 Mohammadi/2015 45 Mohammadi/2016 44 Pacifici/2020 36 Schlagenhauf/2020 37 Shida/2017 38 Smith-Ryan/2019 39 Tubelius/2005 40 Wang/2021 43 West/2020 46 Note. , Yes; , Unclear; , No.1.…”

Section: Probiotic Outcomes In the Occupational Settingmentioning

confidence: 99%

“…40,41,43 Both absenteeism and presentisms were consistently and significantly reduced in the probiotic groups compared with the control groups. 40,42,43 3.5.5 | Other outcomes Several other health outcomes were examined in some studies included in this review that could not be specifically under the four of investigation. For example, sleep quality was measured in two studies using the Pittsburg Sleep Quality Index 46,47 and both studies reported the index to be higher (indicating better sleep quality) in the probiotics groups compared with the control groups.…”

Section: Emotional and Mental Healthmentioning

confidence: 99%

Probiotic supplements and stress-related occupational health outcomes: A scoping review

Jun,

Kasumova,

Tussing

et al. 2023

Journal of Occupational Health

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BackgroundProlonged and constant stress from work often leads to numerous adverse health effects. In recent years, interest in probiotics, living microorganisms that can benefit their host when consumed in adequate amounts, to aid health and well‐being has increased. This scoping review is to systematically evaluate the current state of science on the effects of probiotic supplements on health, stress, and stress‐related symptoms among working adults in occupational settings.MethodsWe performed a systematic scoping review following the Arksey and O'Malley Framework. Studies that examined the effects of probiotics on workers' health and stress‐related indicators/outcomes in occupational settings were included. A comprehensive search was performed from November 2021 to January 2022 using MEDLINE/PubMed, Cochrane Library, CINAHL, PsychInfo, Scopus, and Embase.ResultsA total of 14 papers met the inclusion and exclusion criteria. Probiotics consisted primarily of Lactobacillus and/or Bifidobacterium strains in various forms and doses. Three out of eight studies reported statistical differences in inflammatory markers or stress hormone levels between probiotic and placebo groups. Three of six reported reduced respiratory tract infection incidents in the probiotic groups and three out of four studies reported no differences in anxiety and depression between groups. Lastly, three studies found that absenteeism and presentism were lower in probiotic groups compared with placebo groups.ConclusionThe potential benefits of probiotics exist; however, the measurements of outcomes, the types of probiotics used, and the characteristics of the intervention varied across studies. Further research is needed focusing on probiotics' direct and indirect mechanisms of action on the stress response and the standardization of strains and dosing.

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“…As DNA is an active component, this effect of LC-Plasma is exhibited equally in both live and heat-killed states [ 15 ]. A clinical study in healthy participants reported that live or heat-killed LC-Plasma intake improved the activity of pDCs and also improved work performance [ 17 , 18 ]. In addition, in vivo experiments confirmed that the continuous intake of LC-Plasma improved spontaneous motor activity after exercise, and suppressed an increase in fatigue and the muscle decomposition index [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Ingesting Food Containing Heat-Killed Lactococcus lactis Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study

et al. 2023

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Lactococcus lactis strain Plasma (LC-Plasma) is a unique lactic acid bacterium that activates plasmacytoid dendritic cells (pDCs). We evaluated the effect of LC-Plasma on fatigue indices and dendritic cells activity in athletes after 14 days’ continuous exercise load. Thirty-seven participants were divided into two groups and consumed placebo (PL) or LC-Plasma capsules (containing 100 billion cells) daily for 14 days. Maturation markers on dendritic cells, blood parameters, physiological indices, and fatigue-related indices were recorded on days 1 and 15 (before and after exercise). Cumulative days of symptoms relating to physical conditions were also recorded during the continuous exercise period. We observed that CD86 as a maturation marker on pDCs was significantly higher and that cumulative days of fatigue were significantly fewer in the LC-Plasma group than in the Placebo group on day 15. We also conducted 2 h ergometer exercise on day 15 to evaluate fatigue. The results showed that autonomic fatigue parameters (LF/HF) were significantly lower in the LC-Plasma group. These results suggest that LC-Plasma supplementation alleviates fatigue accumulation and increases pDC activity caused by a continuous high training load.

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Lactococcus lactis Strain Plasma Improves Subjective Physical State and Presenteeism: A Randomized, Open-Label Crossover Study among Healthy Office Workers

Cited by 3 publications

References 15 publications

Effect of Lactococcus lactis Strain Plasma on HHV-6 and HHV-7 Shedding in Saliva: A Prospective Observational Study

Effect of Lactococcus lactis Strain Plasma on HHV-6 and HHV-7 Shedding in Saliva: A Prospective Observational Study

Probiotic supplements and stress-related occupational health outcomes: A scoping review

Effects of Ingesting Food Containing Heat-Killed Lactococcus lactis Strain Plasma on Fatigue and Immune-Related Indices after High Training Load: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Study

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