Lactobionic acid-modified phycocyanin nanoparticles loaded with doxorubicin for synergistic chemo-photodynamic therapy

Liu, Xiaoqing; Du, Jianyong; Xie, Zheng; Wang, Limin; Liu, Xin; Hou, Zhongkai; Wang, Xin; Tang, Rupei

doi:10.1016/j.ijbiomac.2021.07.047

Cited by 13 publications

(5 citation statements)

References 32 publications

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“…In order to overcome these limitations, nanosized PC particles (LAPC/DOX) were prepared by grafting lactonic acid (LA) and loading adriamycin (DOX). Compared with PC solution, the storage stability and photostability of PC particles are significantly improved, and the formation of nanomedicines further improves their biological stability [129]. Zhang et al synthesized pH/reactive ROS dual-responsive PEG-DOX conjugate (labeled TPD) through acyl alkynylamine click reaction by PEG dipropiolate (PEGB), amine-terminated thioketal (TKL), and DOX [126].…”

Section: Organic Materialsmentioning

confidence: 99%

High Drug-Loading Nanomedicines for Tumor Chemo–Photo Combination Therapy: Advances and Perspectives

Zhang

et al. 2022

Pharmaceutics

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The combination of phototherapy and chemotherapy (chemo–photo combination therapy) is an excellent attempt for tumor treatment. The key requirement of this technology is the high drug-loading nanomedicines, which can load either chemotherapy drugs or phototherapy agents at the same nanomedicines and simultaneously deliver them to tumors, and play a multimode therapeutic role for tumor treatment. These nanomedicines have high drug-loading efficiency (>30%) and good tumor combination therapeutic effect with important clinical application potential. Although there are many reports of high drug-loading nanomedicines for tumor therapy at present, systematic analyses on those nanomedicines remain lacking and a comprehensive review is urgently needed. In this review, we systematically analyze the current status of developed high drug-loading nanomedicines for tumor chemo–photo combination therapy and summarize their types, methods, drug-loading properties, in vitro and in vivo applications. The shortcomings of the existing high drug-loading nanomedicines for tumor chemo–photo combination therapy and the possible prospective development direction are also discussed. We hope to attract more attention for researchers in different academic fields, provide new insights into the research of tumor therapy and drug delivery system and develop these nanomedicines as the useful tool for tumor chemo–photo combination therapy in the future.

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Section: Organic Materialsmentioning

confidence: 99%

High Drug-Loading Nanomedicines for Tumor Chemo–Photo Combination Therapy: Advances and Perspectives

Zhang

et al. 2022

Pharmaceutics

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“…However, its therapeutic application is hindered by its short plasma half-life and instability, requiring frequent doses and leading to low patient compliance. [3][4][5] Hydrogels are intricate networks of hydrophilic polymers, able to retain significant amounts of biological fluids or water without dissolution. They present a promising option for various biomedical uses due to their ability to interact well with biological systems, facilitate the transport of nutrients and metabolites, and mimic the native extracellular matrix (ECM).…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of Phycocyanin-Infused Hydrogel Topical Formulations for Wound Healing

Alka,

Saraf

2024

Int. J. Pharm. Sci. Drug Res.

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Wound healing is a complex biological process impaired by several factors, and conventional treatments often result in undesirable side effects. Natural compounds have emerged as favourable alternatives due to their reduced side effects. C-phycocyanin (C-Pc), a natural phycobiliprotein derived from Spirulina platensis, shows promise in wound healing but is hindered by poor stability and low bioavailability. This study aimed to develop a hydrogel-based delivery system for C-Pc to enhance its stability and therapeutic efficacy in wound healing. We synthesized a grafted gum hydrogel to encapsulate C-Pc, ensuring its sustained release. The hydrogel’s physical properties, including clarity, pH, spreadability, and rheological behaviour, were characterized. The encapsulation efficiency, in vitro release profile, antioxidant activity, and adhesion were assessed. Furthermore, the hydrogel’s impact on wound healing was evaluated through in vivo studies and assessments of skin irritation potential. The optimized hydrogel demonstrated excellent physical stability, appropriate viscosity, and significant bioadhesive properties, making it suitable for topical application. The encapsulated C-Pc exhibited a controlled release, enhanced antioxidant activity, and greater wound-healing efficacy than free C-Pc. In vivo studies confirmed accelerated wound closure with no irritation or allergy, suggesting high biocompatibility and therapeutic potential. Developing a C-Pc encapsulated hydrogel presents a promising approach to improving wound care. This innovative approach not only stabilizes C-Pc but also enhances its healing properties, providing a safe and effective option for patients. This study paves the way for a novel formulation with translatory potential.

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“…Pluronic F127 (F127) solution remains in a liquid state at low temperatures but undergoes a transition to a transparent gel when the temperature is raised. − At the lower critical solution temperature (LCST), Pluronic F127 can change from a low-viscosity solution to a semi-solid, which is an ideal material for temperature-sensitive hydrogel for local treatment. , Approximately 15% w/w is the minimum concentration of Pluronic F127 required for gel formation . In addition, phycocyanin (PC) serves as an excellent photosensitizer due to its inherent advantages such as excellent biocompatibility, non-toxicity, favorable water solubility, high absorption in the visible range (550–650 nm), remarkable fluorescence quantum yield, and efficient transfer of captured light energy to the light reaction center. , Thus, if Pluronic F127 and PC are used to prepare hybrid hydrogels, it is expected to obtain a type of hydrogel with thermosensitivity and PTT properties.…”

Section: Introductionmentioning

confidence: 99%

“…37 In addition, phycocyanin (PC) serves as an excellent photosensitizer due to its inherent advantages such as excellent biocompatibility, non-toxicity, favorable water solubility, high absorption in the visible range (550−650 nm), remarkable fluorescence quantum yield, and efficient transfer of captured light energy to the light reaction center. 38,39 Thus, if Pluronic F127 and PC are used to prepare hybrid hydrogels, it is expected to obtain a type of hydrogel with thermosensitivity and PTT properties.…”

Section: Introductionmentioning

confidence: 99%

Thermo-Sensitive Nanoparticle-Hydrogel Composite Based on Pluronic F127 and Phycocyanin for an Enhanced Chemo-Photodynamic Antitumor Effect

Song

Zhang

et al. 2023

ACS Appl. Polym. Mater.

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The concurrent utilization of chemotherapy and photodynamic therapy (PDT) can successfully slow the growth of tumors while minimizing systemic toxicity. An injectable temperature-sensitive hydrogel was constructed based on Pluronic F127 and phycocyanin (PC). Nanoparticles formed by self-assembly of doxorubicin and ursolic acid (DOX–UA NPS) were further loaded into the hydrogel to give a local drug delivery platform (DOX–UA NPs@Gel). DOX–UA NPs@Gel can be enriched in situ in tumors and continuously release DOX–UA NPs and free PC. UA can promote the responsiveness of tumor cells to DOX. As a natural photosensitizer, PC can produce reactive oxygen species (ROS) when exposed to laser radiation and has significant PDT activity. The MTT assay demonstrated that DOX–UA NPs@Gel under irradiation caused the highest cytotoxicity at 91.6%. The anti-tumor efficiency of various nanoparticles and nanoparticle-loaded hydrogels (the injection dose of DOX is 6 mg/kg) was verified in the H22 tumor-bearing mice (male ICR). In vivo antitumor results demonstrated that DOX–UA NPs@Gel with the combination of chemotherapy and PDT exhibited unique anticancer efficacy with low toxicity. When exposed to radiation after the experiment, the DOX–UA NPs@Gel showed a tumor volume of merely 319 mm3, displaying an exceptional tumor growth inhibition rate of 91.05%. Therefore, the local drug delivery system based on the thermosensitive hydrogel can effectively achieve synergistic antitumor effects.

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Lactobionic acid-modified phycocyanin nanoparticles loaded with doxorubicin for synergistic chemo-photodynamic therapy

Cited by 13 publications

References 32 publications

High Drug-Loading Nanomedicines for Tumor Chemo–Photo Combination Therapy: Advances and Perspectives

High Drug-Loading Nanomedicines for Tumor Chemo–Photo Combination Therapy: Advances and Perspectives

Development and Evaluation of Phycocyanin-Infused Hydrogel Topical Formulations for Wound Healing

Thermo-Sensitive Nanoparticle-Hydrogel Composite Based on Pluronic F127 and Phycocyanin for an Enhanced Chemo-Photodynamic Antitumor Effect

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