Lactobacillus rhamnosus GKLC1 ameliorates cisplatin-induced chronic nephrotoxicity by inhibiting cell inflammation and apoptosis

Tsai, You-Shan; Chen, Yen‐Po; Lin, Shih-Wei; Chen, Yen‐Lien; Chen, Chin‐Chu; Huang, Guan‐Jhong

doi:10.1016/j.biopha.2022.112701

Cited by 15 publications

(9 citation statements)

References 52 publications

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“…The ligand–RAGE interaction activates NF-kappaB (NK-ĸB) and increased the expression of cytokines, adhesion molecules, and oxidative stress [ 34 ]. Consistent with other studies in probiotic fermented supernatants, liquid from fermented Lactobacillus rhamnosus showed an inhibitory effect on the expression of NK-ĸB in renal epithelial cells as well as other oxidative markers such as ERK, p53, and Caspase-3 [ 35 ]. We therefore assumed the fermented GKM3- and GKK2-supernatants presented the anti-aging effect by suppressing the relative oxidative markers involved with AGE-RAGE interaction.…”

Section: Discussionsupporting

confidence: 90%

Fermented Supernatants of Lactobacillus plantarum GKM3 and Bifidobacterium lactis GKK2 Protect against Protein Glycation and Inhibit Glycated Protein Ligation

Lin

Jao

et al. 2023

Nutrients

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With age, protein glycation in organisms increases continuously. Evidence from many studies shows that the accumulation of glycated protein is highly correlated with biological aging and the development of aging-related diseases, so developing a dietary agent to attenuate protein glycation is very meaningful. Previous studies have indicated that lactic acid bacteria-fermented products have diverse biological activities especially in anti-aging, so this study was aimed to investigate the inhibitory effect of the fermented supernatants of Lactobacillus plantarum GKM3 (GKM3) and Bifidobacterium lactis GKK2 (GKK2) on protein glycation. The results show that GKM3- and GKK2-fermented supernatants can significantly inhibit protein glycation by capturing a glycation agent (methylglyoxal) and/or protecting functional groups in protein against methylglyoxal-induced responses. GKM3- and GKK2-fermented supernatants can also significantly inhibit the binding of glycated proteins to the receptor for advanced glycation end products (RAGE). In conclusion, lactic acid bacteria fermentation products have the potential to attenuate biological aging by inhibiting protein glycation.

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Section: Discussionsupporting

confidence: 90%

Fermented Supernatants of Lactobacillus plantarum GKM3 and Bifidobacterium lactis GKK2 Protect against Protein Glycation and Inhibit Glycated Protein Ligation

Lin

Jao

et al. 2023

Nutrients

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“…Since the short-chain fatty acids are the secondary metabolites of the gut microbiota, it is possible to choose a strain of bacteria as short-chain fatty acids producer for the probiotic intervention on CKD. Previous studies have shown the renal protective effects of a short-chain fatty acid producer, L. rhamnosus , on a 5/6 nephrectomy mouse model 39 and a cisplatin-induced chronic nephrotoxicity model 40 . Meanwhile, pilot experiments showed that L. rhamnosus could not produce typical uremic toxins such as indole and p -cresol.…”

Section: Resultsmentioning

confidence: 99%

Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota

Pan

et al. 2023

Acta Pharmaceutica Sinica B

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“…However, the exact mechanism has yet not been well understood. K. marxianus has seldom been reported to have the effects on the apoptosis, but it can affect the richness of Lactobacillus, which may be a potential strain to control the apoptosis development in kidney diseases [43]. Creatinine is an important biomarker during the pathogenesis of kidney disease and also affected by K. marxianus treatment, which may also be caused by the regulation of Lactobacillus [44].…”

Section: Discussionmentioning

confidence: 99%

Kluyveromyces marxianus Ameliorates High-Fat-Diet-Induced Kidney Injury by Affecting Gut Microbiota and TLR4/NF-κB Pathway in a Mouse Model

Zhao

2023

Cellular Microbiology

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Objectives. The effects of Kluyveromyces marxianus on high-fat diet- (HFD-) induced kidney injury (KI) were explored. Methods. HFD-induced KI model was established using male C57BL/6 mice and treated with K. marxianus JLU-1016 and acid-resistant (AR) strain JLU-1016A. Glucose tolerance was evaluated via an oral glucose tolerance test (OGTT). KI was measured using Hematoxylin and Eosin (H&E) staining and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) analysis. The chemical indexes were analyzed, including lipid profiles, inflammatory cytokines, and creatinine. The levels of Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) or phospho-NF-κB p65 (Ser536) and alpha inhibitor of NF-κB (IκBα) were measured using qPCR and Western blot. The gut microbiota was sequenced using high-throughput sequencing. Results. HFD induction increased OGTT value, KI severity, oxidative stress, inflammatory cytokines, oxidative stress, apoptotic rate, creatinine levels, and the expression of TLR4/NF-κB, phospho-NF-κB p65 (Ser536), and IκBα deteriorated lipid profiles ( P < 0.05 ) and reduced gut microbiota abundance. K. marxianus treatment ameliorated HFD-induced metabolic disorders and reversed these parameters ( P < 0.05 ). Compared with the control, HFD induction increased the proportion of Firmicutes but reduced the proportion of Bacteroidetes and Lactobacillus. K. marxianus JLU-1016 and AR strain JLU-1016A treatments improved gut microbiota by reducing the proportion of Firmicutes and increasing the proportion of Bacteroidetes and Lactobacillus in the KI model ( P < 0.0001 ). Helicobacter has been identified with many infectious diseases and was increased after HFD induction and inhibited after K. marxianus JLU-1016 and AR strain JLU-1016A treatments. The strain JLU-1016A exhibited better results possibly with acid-tolerance properties to pass through an acidic environment of the stomach. Conclusions. K. marxianus may have a beneficial effect on KI by improving gut microbiota and inhibiting TLR4/NF-κB pathway activation.

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Lactobacillus rhamnosus GKLC1 ameliorates cisplatin-induced chronic nephrotoxicity by inhibiting cell inflammation and apoptosis

Cited by 15 publications

References 52 publications

Fermented Supernatants of Lactobacillus plantarum GKM3 and Bifidobacterium lactis GKK2 Protect against Protein Glycation and Inhibit Glycated Protein Ligation

Fermented Supernatants of Lactobacillus plantarum GKM3 and Bifidobacterium lactis GKK2 Protect against Protein Glycation and Inhibit Glycated Protein Ligation

Berberine ameliorates chronic kidney disease through inhibiting the production of gut-derived uremic toxins in the gut microbiota

Kluyveromyces marxianus Ameliorates High-Fat-Diet-Induced Kidney Injury by Affecting Gut Microbiota and TLR4/NF-κB Pathway in a Mouse Model

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