Lactobacillus rhamnosus CGMCC 1.3724 (LPR) Improves Skin Wound Healing and Reduces Scar Formation in Mice

Moreira, Camila Francisco; Cassini‐Vieira, Puebla; Canesso, Maria Cecília Campos; Felipetto, Mariane; Ranfley, Hedden; Teixeira, Mauro Martins; Nicoli, Jacques Robert; Martins, Flaviano S.; Barcelos, Lucíola da Silva

doi:10.1007/s12602-020-09713-z

Cited by 19 publications

(18 citation statements)

References 44 publications

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“…With regard to L. rhamnosus GG, given orally in a Swiss mouse model, it accelerates skin wound healing, as assessed by the epithelial tongue length and the epithelial gap extent, and reduces scar formation through reduction of inflammation and collagen deposition and increase of angiogenesis [43] . When applied topically, it increases re-epithelization, through induction of the chemokine CXCL2 and its receptor CXCR2, which stimulate keratinocyte proliferation and migration , the cell migration considered as the dominant mechanism of action [ 22 , 41 ].…”

Section: Article In Pressmentioning

confidence: 99%

The 3-D configuration of excisional skin wound healing after topical probiotic application

Moysidis¹,

Stavrou²,

Cheva³

et al. 2022

Injury

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Section: Article In Pressmentioning

confidence: 99%

The 3-D configuration of excisional skin wound healing after topical probiotic application

Moysidis¹,

Stavrou²,

Cheva³

et al. 2022

Injury

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“…Taking into account that some studies have reported the ability of probiotic microorganisms administered orally to exert beneficial effects on the skin [ 40 , 41 , 42 ], we decided to study the ability of W. viridescens UCO-SMC3 to resist simulated gastrointestinal conditions in vitro . These studies were carried out in comparison with the probiotic strain L. fermentum UCO-979C [ 43 , 44 ].…”

Section: Resultsmentioning

confidence: 99%

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

et al. 2021

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Previously, we isolated lactic acid bacteria from the slime of the garden snail Helix aspersa Müller and selected Weissella viridescens UCO-SMC3 because of its ability to inhibit in vitro the growth of the skin-associated pathogen Cutibacterium acnes. The present study aimed to characterize the antimicrobial and immunomodulatory properties of W. viridescens UCO-SMC3 and to demonstrate its beneficial effect in the treatment of acne vulgaris. Our in vitro studies showed that the UCO-SMC3 strain resists adverse gastrointestinal conditions, inhibits the growth of clinical isolates of C. acnes, and reduces the adhesion of the pathogen to keratinocytes. Furthermore, in vivo studies in a mice model of C. acnes infection demonstrated that W. viridescens UCO-SMC3 beneficially modulates the immune response against the skin pathogen. Both the oral and topical administration of the UCO-SCM3 strain was capable of reducing the replication of C. acnes in skin lesions and beneficially modulating the inflammatory response. Of note, orally administered W. viridescens UCO-SMC3 induced more remarkable changes in the immune response to C. acnes than the topical treatment. However, the topical administration of W. viridescens UCO-SMC3 was more efficient than the oral treatment to reduce pathogen bacterial loads in the skin, and effects probably related to its ability to inhibit and antagonize the adhesion of C. acnes. Furthermore, a pilot study in acne volunteers demonstrated the capacity of a facial cream containing the UCO-SMC3 strain to reduce acne lesions. The results presented here encourage further mechanistic and clinical investigations to characterize W. viridescens UCO-SMC3 as a probiotic for acne vulgaris treatment.

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“…Enhanced wound healing, increased collagen production Khodaii, 2019 [20] Animal model study L. reuteri Enhanced collagen production, accelerated wound healing Han, 2019 [21] Animal model study L. reuteri Promoted wound healing through activation of GMSCs Han, 2020 [26] Animal model study L. reuteri Inhibited inflammation and enhanced wound healing through promoting MSCs Mohtashami, 2020 [23] Animal model study L. bulgaricus, L. plantarum Enhanced wound healing Ong, 2020 [24] Animal model study L. plantarum Suppressed Staphylococcus aureus, and thereby improved wound healing Moreira, 2021 [25] Animal model study L. johnsonii, L. paracasei, and L. rhamnosus Promoted skin wound closure and decreased scar formation and inflammation healing to milk and dairy products [6]. Compared to the international collective, there was a striking difference regarding the sources of information given by OMFS and specialist dentists for oral surgery (Table 8).…”

Section: Discussionmentioning

confidence: 99%

Avoidance of milk and dairy products after oral surgery—is such a recommendation still valid? A cross-sectional study among German and international oral and maxillofacial surgeons and dental practitioners with review of the literature

Moghaddam

Neff

2021

Oral Maxillofac Surg

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Purpose For prevention of wound-healing complications, patients in German-speaking countries are traditionally advised to avoid consumption of milk and dairy products after oral surgery. In the absence of national and international guidelines, this study investigates scientific evidence and compares international practice, frequency scale, and rationale behind such recommendation. Methods Comparison of a German cross-sectional mono-center-questionnaire pilot study and a survey among international oral and maxillofacial surgeons (OMFS), specialized oral surgeons and general dentists, evaluating international practice regarding post-operative dietary and nutrition recommendations. Our literature review further assessed scientific evidence for relevant effects of probiotics, prebiotics, and/or synbiotics. Results Among German study participants, 56% (n = 64/114) advise patients to avoid milk and dairy products, with 42% of OMFS (n = 38) and 65% (n = 76) of the general dentists recommending abstention (p = .027). In striking contrast, such recommendation could not be identified in our international survey (n = 143) (t test, p < .001) nor in the literature. There were significant differences between German and international study participants regarding the rationale for dietary recommendations, with dental schools and literature most frequently indicated as sources (Fisher’s exact test, p < .001). Conclusion The hypothesis of a harmful effect of the consumption of milk and dairy products after dentoalveolar surgery could not be supported by evidence. The recommendation to avoid dairy products post-surgery was identified as a specific phenomenon practiced almost exclusively in German-speaking countries. Corresponding recommendations, most probably based on a now irrelevant risk of contracting tuberculosis from milk products, can at present no longer be substantiated.

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Lactobacillus rhamnosus CGMCC 1.3724 (LPR) Improves Skin Wound Healing and Reduces Scar Formation in Mice

Cited by 19 publications

References 44 publications

The 3-D configuration of excisional skin wound healing after topical probiotic application

The 3-D configuration of excisional skin wound healing after topical probiotic application

Characterization of Weissella viridescens UCO-SMC3 as a Potential Probiotic for the Skin: Its Beneficial Role in the Pathogenesis of Acne Vulgaris

Avoidance of milk and dairy products after oral surgery—is such a recommendation still valid? A cross-sectional study among German and international oral and maxillofacial surgeons and dental practitioners with review of the literature

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