Lactobacillus plantarum TW1-1 Alleviates Diethylhexylphthalate-Induced Testicular Damage in Mice by Modulating Gut Microbiota and Decreasing Inflammation

Tian, Xiaozhu; Yu, Zhengsheng; Feng, Ping; Ye, Ze; Li, Rong; Liu, Juyuan; Hu, Junping; Kakade, Apurva; Liu, Pu

doi:10.3389/fcimb.2019.00221

Cited by 71 publications

(50 citation statements)

References 58 publications

(77 reference statements)

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“…At the genus level, Prevotella and Bacteroidales were negatively associated with testicular function, while Paraprevotella, Mucispirillum, Oscillospira, Coprococcus and Lactobacillus were positively correlated with that function. 63 , 68 JL-3 pretreatment reduced the increase of Prevotella and Bacteroidales , and elevated the decrease of Paraprevotella, Mucispirillum, Oscillospira and Lactobacillus in UA-exposed mice by regulating intestinal flora and improving intestinal function to alleviate gout. 62 , 63 In addition, the low abundance inherent strain of Erysipelatoclostridium that appears in a host colitis by competing for nutrients negatively affected the flora.…”

Section: Discussionmentioning

confidence: 92%

Limosilactobacillus fermentum JL-3 isolated from “Jiangshui” ameliorates hyperuricemia by degrading uric acid

Feng

et al. 2021

Gut Microbes

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Recent studies into the beneficial effects of fermented foods have shown that this class of foods are effective in managing hyperuricemia and gout. In this study, the uric acid (UA) degradation ability of Limosilactobacillus fermentum JL-3 strain, isolated from “Jiangshui” (a fermented Chinese food), was investigated. In vitro results showed that JL-3 strain exhibited high degradation capacity and selectivity toward UA. After oral administration to mice for 15 days, JL-3 colonization was continuously detected in the feces of mice. The UA level in urine of mice fed with JL-3 was similar with the control group mice. And the serum UA level of the former was significantly lower (31.3%) than in the control, further confirmed the UA-lowering effect of JL-3 strain. Limosilactobacillus fermentum JL-3 strain also restored some of the inflammatory markers and oxidative stress indicators (IL-1β, MDA, CRE, blood urea nitrogen) related to hyperuricemia, while the gut microbial diversity results showed that JL-3 could regulate gut microbiota dysbiosis caused by hyperuricemia. Therefore, the probiotic Limosilactobacillus fermentum JL-3 strain is effective in lowering UA levels in mice and could be used as a therapeutic adjunct agent in treating hyperuricemia.

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Section: Discussionmentioning

confidence: 92%

Limosilactobacillus fermentum JL-3 isolated from “Jiangshui” ameliorates hyperuricemia by degrading uric acid

Feng

et al. 2021

Gut Microbes

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“…For example, the amount of SOD and glutathione in weanling piglets could increase due to L. fermentum administration, with the enhanced capacity to inhibit O 2 •− formation in muscle and liver, which can contribute to the modulation of oxidative stress in relevant organs [ 117 ]. Recent research also reported the preventive capacity of a L. plantarum strain, administered orally, on Di-2-ethylhexyl phthalate (DEHP)-induced testicular damage in mice [ 118 ]. In addition, few oxidative stresses-induced cardiovascular diseases and metabolic syndrome may be alleviated by Lactobacillus spp.…”

Section: Potential Applicationmentioning

confidence: 99%

The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract

Kong

Olejar

et al. 2020

Antioxidants

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The gastrointestinal (GI) tract is crucial for food digestion and nutrient absorption in humans. However, the GI tract is usually challenged with oxidative stress that can be induced by various factors, such as exogenous pathogenic microorganisms and dietary alterations. As a part of gut microbiota, Lactobacillus spp. play an important role in modulating oxidative stress in cells and tissues, especially in the GI tract. Oxidative stress is linked with excessive reactive oxygen species (ROS) that can be formed by a few enzymes, such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOXs). The redox mechanisms of Lactobacillus spp. may contribute to the downregulation of these ROS-forming enzymes. In addition, nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf-2) and nuclear factor kappa B (NF-κB) are two common transcription factors, through which Lactobacillus spp. modulate oxidative stress as well. As oxidative stress is closely associated with inflammation and certain diseases, Lactobacillus spp. could potentially be applied for early treatment and amelioration of these diseases, either individually or together with prebiotics. However, further research is required for revealing their mechanisms of action as well as their extensive application in the future.

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“…Besides, the decreased abundance of Lachnospiraceae_NK4A136_group was also observed in hydrocortisone-induced depressant rats [ 10 ]. Lactobacillus , a pivotal component of the Firmicutes phylum, usually affects the immune system [ 70 ]. Lactobacillus plantarum TW1-1 , isolated from a fermented milk product, was reported to modulate gut microbiota and have anti-inflammatory and anti-oxidative stress activities [ 70 ].…”

Section: Discussionmentioning

confidence: 99%

Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice

Gao

Zhou

et al. 2021

J Transl Med

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Background Given the clinical low efficient treatment based on mono-brain-target design in Alzheimer’s disease (AD) and an increasing emphasis on microbiome-gut-brain axis which was considered as a crucial pathway to affect the progress of AD along with metabolic changes, integrative metabolomic signatures and microbiotic community profilings were applied on the early age (2-month) and mature age (6-month) of presenilin1/2 conditional double knockout (PS cDKO) mice which exhibit a series of AD-like phenotypes, comparing with gender and age-matched C57BL/6 wild-type (WT) mice to clarify the relationship between microbiota and metabolomic changes during the disease progression of AD. Materials and methods Urinary and fecal samples from PS cDKO mice and gender-matched C57BL/6 wild-type (WT) mice both at age of 2 and 6 months were collected. Urinary metabolomic signatures were measured by the gas chromatography-time-of-flight mass spectrometer, as well as 16S rRNA sequence analysis was performed to analyse the microbiota composition at both ages. Furthermore, combining microbiotic functional prediction and Spearman’s correlation coefficient analysis to explore the relationship between differential urinary metabolites and gut microbiota. Results In addition to memory impairment, PS cDKO mice displayed metabolic and microbiotic changes at both of early and mature ages. By longitudinal study, xylitol and glycine were reduced at both ages. The disturbed metabolic pathways were involved in glycine, serine and threonine metabolism, glyoxylate and dicarboxylate metabolism, pentose and glucuronate interconversions, starch and sucrose metabolism, and citrate cycle, which were consistent with functional metabolic pathway predicted by the gut microbiome, including energy metabolism, lipid metabolism, glycan biosynthesis and metabolism. Besides reduced richness and evenness in gut microbiome, PS cDKO mice displayed increases in Lactobacillus, while decreases in norank_f_Muribaculaceae, Lachnospiraceae_NK4A136_group, Mucispirillum, and Odoribacter. Those altered microbiota were exceedingly associated with the levels of differential metabolites. Conclusions The urinary metabolomics of AD may be partially mediated by the gut microbiota. The integrated analysis between gut microbes and host metabolism may provide a reference for the pathogenesis of AD.

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Lactobacillus plantarum TW1-1 Alleviates Diethylhexylphthalate-Induced Testicular Damage in Mice by Modulating Gut Microbiota and Decreasing Inflammation

Cited by 71 publications

References 58 publications

Limosilactobacillus fermentum JL-3 isolated from “Jiangshui” ameliorates hyperuricemia by degrading uric acid

Limosilactobacillus fermentum JL-3 isolated from “Jiangshui” ameliorates hyperuricemia by degrading uric acid

The Potential of Lactobacillus spp. for Modulating Oxidative Stress in the Gastrointestinal Tract

Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice

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