Lactobacillus plantarum culture supernatants improve intestinal tissue exposed to deoxynivalenol

Maidana, L; Gerez, Juliana Rubira; Pinho, Flaviane Alves de; García, Sandra; Bracarense, Ana Paula Frederico Rodrigues Loureiro

doi:10.1016/j.etp.2017.06.005

Cited by 16 publications

(7 citation statements)

References 51 publications

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“…As shown by previous studies, the main function of L. plantarum was regulating the gut microbiota and further enhancing the intestinal digestive function [ 52 – 55 ]. The significantly altered microbiota between the DON and DL groups were further identified.…”

Section: Discussionmentioning

confidence: 92%

“…One of the many strategies to counteract the harmful effects of DON is the addition of probiotics [ 50 , 51 ]. Lactobacillus , which improves performance, promotes the digestion and utilization, and prevents intestinal epithelial barrier dysfunction and immune responses, could be used to alleviate the harmful effects of DON [ 52 – 55 ]. Nevertheless, the magnitude of the effect seems to be strain dependent and host specific.…”

Section: Discussionmentioning

confidence: 99%

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Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens

Liu

Duan

et al. 2018

J Animal Sci Biotechnol

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BackgroundLimited research has focused on the effect of Lactobacillus on the intestinal toxicity of deoxynivalenol (DON). The present study was conducted to investigate the role of Lactobacillus plantarum (L. plantarum) JM113 in protecting against the intestinal toxicity caused by DON.MethodsA total of 144 one-day-old healthy Arbor Acres broilers were randomly distributed into 3 treatments, including the CON (basal diet), the DON (extra 10 mg/kg deoxynivalenol), and the DL (extra 1 × 109 CFU/ kg L. plantarum JM113 based on DON group) treatments. The growth performance, organ indexes, intestinal morphology, pancreatic digestive enzymes, intestinal secreted immunoglobulin A (sIgA), jejunal transcriptome, and intestinal microbiota were evaluated.ResultsCompared with the CON and DL groups, the DON supplementation altered intestinal morphology, especially in duodenum and jejunum, where villi were shorter and crypts were deeper (P < 0.05). Meanwhile, the significantly decreased mRNA expression of jejunal claudin-1 and occludin (P < 0.05), ileal rBAT and jejunal GLUT1 of 21-day-old broilers (P < 0.05), as well as duodenal PepT1 and ileal rBAT of 42-day-old broilers were identified in the DON group. Moreover, supplementation with L. plantarum JM113 could increase duodenal expression of IL-10 and IL-12 of 21-day-old broilers, ileal sIgA of 42-day-old broilers, and the bursa of Fabricius index of 21-day-old broilers. Further jejunal transcriptome proved that the genes related to the intestinal absorption and metabolism were significantly reduced in the DON group but a significant increase when supplemented with extra L. plantarum JM113. Furthermore, the bacteria related to nutrient utilization, including the Proteobacteria, Escherichia, Cc-115 (P < 0.05), Lactobacillus and Prevotella (P < 0.1) were all decreased in the DON group. By contrast, supplementation with L. plantarum JM113 increased the relative abundance of beneficial bacterium, including the Bacteroidetes, Roseburia, Anaerofustis, Anaerostipe, and Ruminococcus bromii (P < 0.05). Specifically, the increased abundance of bacteria in the DL group could be proved by the significantly increased caecal content of propionic acid, n-Butyric acid, and total short-chain fatty acid.ConclusionsL. plantarum JM113 enhanced the digestion, absorption, and metabolic functions of the gut when challenged with DON by reducing the injury to intestinal barriers and by increasing the abundance of beneficial bacterium.Electronic supplementary materialThe online version of this article (10.1186/s40104-018-0286-5) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens

Liu

Duan

et al. 2018

J Animal Sci Biotechnol

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“…The potential of L. rhamnosus RC007 to eliminate intestinal toxicity caused by DON in an ex vivo porcine model has been reported in a recent study (Garcia et al., ), in which L. rhamnosus RC007 prevented DON‐related toxic effects on jejunal explants, including paracellular permeability, histological alterations, increased phosphorylation of MAP kinases p38 and p42/p44, and increased expression of pro‐inflammatory cytokines. In another study (Maidana, Gerez, Pinho, Garcia, & Bracarense, ), the oral exposure of DON to 24 days old piglets resulted in defects in histological and morphometric parameters of intestinal tissues, which included apical necrosis, villi atrophy, and a decrease in villi height. Exposure of CFS of two L. plantarum strains in combination with DON significantly prevented these toxic effects on intestinal mucosa layers in piglets.…”

Section: Protection Provided By Lab Against the Toxic Effects Of Mycomentioning

confidence: 93%

Lactic Acid Bacteria as Antifungal and Anti‐Mycotoxigenic Agents: A Comprehensive Review

Sadiq

Yan

Tian

et al. 2019

Comp Rev Food Sci Food Safe

221

111

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Fungal contamination of food and animal feed, especially by mycotoxigenic fungi, is not only a global food quality concern for food manufacturers, but it also poses serious health concerns because of the production of a variety of mycotoxins, some of which present considerable food safety challenges. In today's mega‐scale food and feed productions, which involve a number of processing steps and the use of a variety of ingredients, fungal contamination is regarded as unavoidable, even good manufacturing practices are followed. Chemical preservatives, to some extent, are successful in retarding microbial growth and achieving considerably longer shelf‐life. However, the increasing demand for clean label products requires manufacturers to find natural alternatives to replace chemically derived ingredients to guarantee the clean label. Lactic acid bacteria (LAB), with the status generally recognized as safe (GRAS), are apprehended as an apt choice to be used as natural preservatives in food and animal feed to control fungal growth and subsequent mycotoxin production. LAB species produce a vast spectrum of antifungal metabolites to inhibit fungal growth; and also have the capacity to adsorb, degrade, or detoxify fungal mycotoxins including ochratoxins, aflatoxins, and Fusarium toxins. The potential of many LAB species to circumvent spoilage associated with fungi has been exploited in a variety of human food and animal feed stuff. This review provides the most recent updates on the ability of LAB to serve as antifungal and anti‐mycotoxigenic agents. In addition, some recent trends of the use of LAB as biopreservative agents against fungal growth and mycotoxin production are highlighted.

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“…Maidana et al. (2017) indicated that Lactobacillus rhamnosus GG (1.1 × 10 8 and 2.0 × 10 9 CFU/mL) can repress ER stress induced by DON (10 μmol/L), improving intestinal barrier function and microbiota. Furthermore, it (1.0 × 10 9 CFU/day) can also increase the abundance of Bacteroidetes and the levels of the butyrate‐producing genes But and Buk to improve butyrate production, and butyrate will inhibit the IRE1α/XBP1 signaling pathway to reduce DON‐induced (3.0 mg/kg bw/day) intestinal injury (Lin et al., 2020).…”

Section: Don Biological Detoxification Methods and Nutritional Mitiga...mentioning

confidence: 99%

Global distribution, toxicity to humans and animals, biodegradation, and nutritional mitigation of deoxynivalenol: A review

Liu

Cai

et al. 2023

Comp Rev Food Sci Food Safe

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Deoxynivalenol (DON) is one of the main types of B trichothecenes, and it causes health‐related issues in humans and animals and imposes considerable challenges to food and feed safety globally each year. This review investigates the global hazards of DON, describes the occurrence of DON in food and feed in different countries, and systematically uncovers the mechanisms of the various toxic effects of DON. For DON pollution, many treatments have been reported on the degradation of DON, and each of the treatments has different degradation efficacies and degrades DON by a distinct mechanism. These treatments include physical, chemical, and biological methods and mitigation strategies. Biodegradation methods include microorganisms, enzymes, and biological antifungal agents, which are of great research significance in food processing because of their high efficiency, low environmental hazards, and drug resistance. And we also reviewed the mechanisms of biodegradation methods of DON, the adsorption and antagonism effects of microorganisms, and the different chemical transformation mechanisms of enzymes. Moreover, nutritional mitigation including common nutrients (amino acids, fatty acids, vitamins, and microelements) and plant extracts was discussed in this review, and the mitigation mechanism of DON toxicity was elaborated from the biochemical point of view. These findings help explore various approaches to achieve the best efficiency and applicability, overcome DON pollution worldwide, ensure the sustainability and safety of food processing, and explore potential therapeutic options with the ability to reduce the deleterious effects of DON in humans and animals.

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Lactobacillus plantarum culture supernatants improve intestinal tissue exposed to deoxynivalenol

Cited by 16 publications

References 51 publications

Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens

Intestinal toxicity of deoxynivalenol is limited by supplementation with Lactobacillus plantarum JM113 and consequentially altered gut microbiota in broiler chickens

Lactic Acid Bacteria as Antifungal and Anti‐Mycotoxigenic Agents: A Comprehensive Review

Global distribution, toxicity to humans and animals, biodegradation, and nutritional mitigation of deoxynivalenol: A review

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