Lactobacillus pentosus KF340 alleviates house dust mite-induced murine atopic dermatitis via the secretion of IL-10-producing splenic B10 cells

Bae, Min-Jung; Kim, Hyun-keun; Lim, Seonung; Lee, So‐Young; Shin, Hee Soon; Kim, Jung-Eun; Im, Sungbin; Kim, Sun‐Young

doi:10.1016/j.jff.2016.07.018

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…Earlier, it has been reported that LP340 induced IL-10 production from peyer's patch DCs. These DCs induced regulatory splenic B10 cells which were protective in house dust mite (HDM) induced dermatitis in mice (16). However, here, we report that LP340 induces both local and systemic APCs to produce IL-27 and IL-10 which propels differentiation of naïve CD4 + T cells into IL-10 producing Tr-1 cells.…”

Section: Introductionmentioning

confidence: 77%

Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells

Kim

Sharma

et al. 2019

Immune Netw

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Several gut commensals have been shown to modulate host immune response. Recently, many food derived microbes have also been reported to affect the immune system. However, a mechanism to identify immunostimulatory and immunoregulatory microbes is needed. Here, we successfully established an in vitro screening system and identified an immunoregulatory bacterium, Lactobacillus pentosus KF340 (LP340), present in various fermented foods. LP340 induced a regulatory phenotype in mice Ag presenting cells which, in turn, induced IL-10 and IFN-γ producing Type 1 regulatory T cells (Tr1 cells) from naïve CD4 + T cells. Naïve CD4 + T cells co-cultured with LP340 treated dendritic cells highly expressed cytokine receptor IL-27R and were CD49b and lymphocyte-activation gene 3 double positive. Oral administration of LP340 in mice with atopic dermatitis reduced cellular infiltration in affected ear lobes and serum IgE levels, thus, ameliorating the disease symptoms. This suggests a systemic immunoregulatory effect of LP340. These findings demonstrate that LP340, a bacterium derived from food, prevents systemic inflammation through the induction of IL-10 producing Tr1 cells.

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Section: Introductionmentioning

confidence: 77%

Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells

Kim

Sharma

et al. 2019

Immune Netw

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“…59 CD4 + CD25 + Tregs are essential for the regulation of immune tolerance and inhibit the differentiation of naive CD4 T cells into Th2 cells. 10 Probiotics prevent inflammatory diseases by inducing tol-DCs, 47,57 Tregs, 21,34,46 and Bregs 55 to promote IL10 secretion. Microorganisms including Lactobacillus paracase i KBL382, 46 Ruminococcus gnavus , 56 Duolac ATP, 34 and Lactobacillus sakei Probio 65 21 exert their anti-allergic effects by inducing Foxp3 + Treg cells.…”

Section: Discussionmentioning

confidence: 99%

“…53,54 Many studies show that AD is alleviated by increasing the anti-inflammatory cytokine IL10. 34,46,47,[55][56][57] IL10 production increases in the AD-induced group compared to the normal group, and IL10 is increased to a greater degree when Lactobacillus paracasei KBL382 is orally administered, resulting in Th2 cytokine (such as IL4, IL5, and IL13), IgE, and TSLP inhibitory activity to alleviate AD. 46 Additionally, IL10 increases in the AD model induced by epidermal sensitization with OVA compared to the normal group but IL4, IL13, TSLP, and IgE were suppressed as IL10 increased through oral administration of Ruminococcus gnavus.…”

Section: Papermentioning

confidence: 99%

Pediococcus pentosaceus KF159 alleviates house dust mite-induced atopic dermatitis by promoting IL10 production and regulatory T cell induction

Eom,

Shin,

Kim

et al. 2024

Food Funct.

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“…In addition, TLR9 signaling activated by immunostimulatory bacterial CpG DNA sequences is essential for mediating the anti-inflammatory effects of probiotic strains. IL-10 is an antiinflammatory cytokine that can promote B lymphocyte activation, produce a large number of antibodies, and promote humoral immune responses (Bae et al, 2016;Štofilová et al, 2017). IFN-α and IFN-γ can activate macrophages, enhance phagocytosis of pathogenic bacteria, and play an important role in anti-tumor immune regulation (Thakur et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Two strains of probiotic Lactobacillus enhance immune response and promote naive T cell polarization to Th1

Ren

Wang

Liu

et al. 2019

Food and Agricultural Immunology

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We co-cultured Caco-2 cells with Lactobacillus salivarius and L. plantarum in vitro to investigate their immunoregulatory mechanisms and detected Lactobacillus strains adhering to Caco-2 cells expressing mRNAs of cytokines and Toll-like receptors (TLRs) by fluorescent quantitative reverse transcription-polymerase chain reaction. The strains were intragastrically administered to mice. Thymus/spleen indexes were measured on different days. 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay, flow cytometry, and enzyme-linked immunosorbent assay were performed to assess different variables. Results showed increased mRNA expressions of T helper 1 (Th1), various cytokines, surface receptors, TLRs (2, 4, and 9), thymus/spleen indexes, spleen lymphocyte transformation rate, macrophage energy metabolism and phagocytosis, CD11c + CD80 + cell number, interferon-γ secretion, and sIgA secretion levels; inhibition of nuclear factor-κB inflammation signal pathway; and downregulated mRNA expression of specific interleukins. Both Lactobacillus strains can promote naive T cell differentiation (Th1) and participate in immunomodulatory responses, featuring a potential in prevention and management approaches for foodborne diseases. ARTICLE HISTORY

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Lactobacillus pentosus KF340 alleviates house dust mite-induced murine atopic dermatitis via the secretion of IL-10-producing splenic B10 cells

Cited by 6 publications

References 38 publications

Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells

Lactobacillus pentosus Modulates Immune Response by Inducing IL-10 Producing Tr1 Cells

Pediococcus pentosaceus KF159 alleviates house dust mite-induced atopic dermatitis by promoting IL10 production and regulatory T cell induction

Two strains of probiotic Lactobacillus enhance immune response and promote naive T cell polarization to Th1

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