Lactobacillus GG and acute diarrhoea in young children in the tropics

Pant, Arjun Raj; Graham, Stephen M.; Allen, Stephen; Harikul, S; Sabchareon, Arunee; Cuevas, Luís E.; Hart, C. A.

doi:10.1093/tropej/42.3.162

Cited by 118 publications

(52 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In RCTs investigating their therapeutic efficacy, they have been generally used in association with ORS (293). In RTCs, L. rhamnosus GG alone or in combination with ORS has demonstrated therapeutic efficacy in significantly reducing by at least half the duration of acute diarrhea mainly resulting from rotavirus infection in children (296)(297)(298)(299)(300)(301)(302)(303)(304)(305)(306)(307)(308)(309)(310). Two meta-analyses have been conducted to specifically examine the RCTs conducted with L. rhamnosus GG (311,312).…”

Section: Therapeutic Effects Against Various Forms Of Acute Diarrheamentioning

confidence: 99%

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

2014

View full text Add to dashboard Cite

SUMMARY A vast and diverse array of microbial species displaying great phylogenic, genomic, and metabolic diversity have colonized the gastrointestinal tract. Resident microbes play a beneficial role by regulating the intestinal immune system, stimulating the maturation of host tissues, and playing a variety of roles in nutrition and in host resistance to gastric and enteric bacterial pathogens. The mechanisms by which the resident microbial species combat gastrointestinal pathogens are complex and include competitive metabolic interactions and the production of antimicrobial molecules. The human intestinal microbiota is a source from which Lactobacillus probiotic strains have often been isolated. Only six probiotic Lactobacillus strains isolated from human intestinal microbiota, i.e., L. rhamnosus GG, L. casei Shirota YIT9029, L. casei DN-114 001, L. johnsonii NCC 533, L. acidophilus LB, and L. reuteri DSM 17938, have been well characterized with regard to their potential antimicrobial effects against the major gastric and enteric bacterial pathogens and rotavirus. In this review, we describe the current knowledge concerning the experimental antibacterial activities, including antibiotic-like and cell-regulating activities, and therapeutic effects demonstrated in well-conducted, placebo-controlled, randomized clinical trials of these probiotic Lactobacillus strains. What is known about the antimicrobial activities supported by the molecules secreted by such probiotic Lactobacillus strains suggests that they constitute a promising new source for the development of innovative anti-infectious agents that act luminally and intracellularly in the gastrointestinal tract.

show abstract

Section: Therapeutic Effects Against Various Forms Of Acute Diarrheamentioning

confidence: 99%

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

2014

View full text Add to dashboard Cite

show abstract

“…Lactobacillus strains have been investigated for their probiotic activity in gut and vaginal environments. Treatment with Lactobacillus rhamnosus GG, for instance, results in improved recovery from and reduces the incidence of diarrhea compared to placebo (249,271,336). Additionally, strains of L. rhamnosus and Lactobacillus reuteri improved treatment rates of bacterial vaginosis in women who were given metronidazole treatment compared to women who received metronidazole and a placebo (16).…”

Section: Susceptibility To Invasionmentioning

confidence: 99%

From Structure to Function: the Ecology of Host-Associated Microbial Communities

Robinson

Bohannan

Young

2010

Microbiol Mol Biol Rev

347

310

View full text Add to dashboard Cite

SUMMARY In the past several years, we have witnessed an increased interest in understanding the structure and function of the indigenous microbiota that inhabits the human body. It is hoped that this will yield novel insight into the role of these complex microbial communities in human health and disease. What is less appreciated is that this recent activity owes a great deal to the pioneering efforts of microbial ecologists who have been studying communities in non-host-associated environments. Interactions between environmental microbiologists and human microbiota researchers have already contributed to advances in our understanding of the human microbiome. We review the work that has led to these recent advances and illustrate some of the possible future directions for continued collaboration between these groups of researchers. We discuss how the application of ecological theory to the human-associated microbiota can lead us past descriptions of community structure and toward an understanding of the functions of the human microbiota. Such an approach may lead to a shift in the prevention and treatment of human diseases that involves conservation or restoration of the normal community structure and function of the host-associated microbiota.

show abstract

“…Pharmaceutical products made from such probiotic bacteria have been clinically employed to ameliorate diarrheal symptoms through stabilizing gut microflora. For example, Lactobacillus GG was protective in acute infantile diarrhea (13) and pseudomembranous post-antibiotic colitis (20) in humans. When we look into animal models, many invasive strains of bacteria are also attenuated by probiotic microorganisms.…”

mentioning

confidence: 99%

The Effect of Lactobacillus rhamnosus on Enterohemorrhagic Escherichia coli Infection of Human Intestinal Cells In Vitro

Hirano

Yoshida

Sugiyama

et al. 2003

Microbiology and Immunology

View full text Add to dashboard Cite

There are many examples of probiotic effects of various lactic bacteria on enteropathogens. In this study, Lactobacillus strains (L. rhamnosus, L. gasseri, L. casei and L. plantarum) were tested in an in vitro model of enterohemorrhagic Escherichia coli (EHEC) infection of a human colon epithelial cell line, C2BBe1. While the adhesion and colonization of EHEC was not affected by any of the lactobacillus strains tested, the internalization of EHEC into the cell line was markedly suppressed by L. rhamnosus, though not by others. Concerning the possible mechanisms, the viabilities of EHEC and host cell were not affected by the presence of L. rhamnosus. Simple competitions at certain receptors were unlikely because the suppressive effect on EHEC internalization was strictly dependent on viable L. rhamnosus and could not be observed with the conditioned medium or killed L. rhamnosus. The fact that L. rhamnosus showed outstanding potential for adhering to the colon epithelial cell line, compared with other strains, suggested that an avid interaction between L. rhamnosus and the host cell might be modulating intra-cellular events responsible for the internalization of EHEC.

show abstract

Lactobacillus GG and acute diarrhoea in young children in the tropics

Cited by 118 publications

References 0 publications

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

From Structure to Function: the Ecology of Host-Associated Microbial Communities

The Effect of Lactobacillus rhamnosus on Enterohemorrhagic Escherichia coli Infection of Human Intestinal Cells In Vitro

Contact Info

Product

Resources

About