Lactobacillus GG Administered in Oral Rehydration Solution to Children with Acute Diarrhea: A Multicenter European Trial

Guandalini, Stefano; Pensabene, Licia; Zikri, Mona Abu; Dias, Jorge Amil; Casali, L Gobio; Hoekstra, Harm; Kolaček, Sanja; Massar, K; Mičetić-Turk, Dušanka; Papadopoulou, Alexandra; Sousa, J. M. C.; Sandhu, Bhupinder; Szajewska, Hania; Weizman, Zvi

doi:10.1097/00005176-200001000-00018

Cited by 533 publications

(268 citation statements)

References 21 publications

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“…In RCTs investigating their therapeutic efficacy, they have been generally used in association with ORS (293). In RTCs, L. rhamnosus GG alone or in combination with ORS has demonstrated therapeutic efficacy in significantly reducing by at least half the duration of acute diarrhea mainly resulting from rotavirus infection in children (296)(297)(298)(299)(300)(301)(302)(303)(304)(305)(306)(307)(308)(309)(310). Two meta-analyses have been conducted to specifically examine the RCTs conducted with L. rhamnosus GG (311,312).…”

Section: Therapeutic Effects Against Various Forms Of Acute Diarrheamentioning

confidence: 99%

“…While the numerous experimental in vitro and in vivo data reported above demonstrated the bactericidal activity of L. rhamnosus GG against enterovirulent bacteria, it is both surprising and intriguing to note that therapeutic efficacy was absent in RCTs conducted with this probiotic strain in children with established bacterially induced diarrhea (302,305,314,326). Consistent with the in vitro and in vivo antibacterial activities reported above for live and heat-treated L. acidophilus strain LB against enteroadherent and enteroinvasive bacteria (122,137,147,181,182), two RCTs have demonstrated the therapeutic efficacy of Lacteol in combination with ORS in decreasing the frequency and duration (reduced by at least half) of enterovirulent bacterium-associated acute watery diarrhea in children between the ages of 1 and 4 years (207,327).…”

Section: Therapeutic Effects Against Various Forms Of Acute Diarrheamentioning

confidence: 99%

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Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

2014

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SUMMARY A vast and diverse array of microbial species displaying great phylogenic, genomic, and metabolic diversity have colonized the gastrointestinal tract. Resident microbes play a beneficial role by regulating the intestinal immune system, stimulating the maturation of host tissues, and playing a variety of roles in nutrition and in host resistance to gastric and enteric bacterial pathogens. The mechanisms by which the resident microbial species combat gastrointestinal pathogens are complex and include competitive metabolic interactions and the production of antimicrobial molecules. The human intestinal microbiota is a source from which Lactobacillus probiotic strains have often been isolated. Only six probiotic Lactobacillus strains isolated from human intestinal microbiota, i.e., L. rhamnosus GG, L. casei Shirota YIT9029, L. casei DN-114 001, L. johnsonii NCC 533, L. acidophilus LB, and L. reuteri DSM 17938, have been well characterized with regard to their potential antimicrobial effects against the major gastric and enteric bacterial pathogens and rotavirus. In this review, we describe the current knowledge concerning the experimental antibacterial activities, including antibiotic-like and cell-regulating activities, and therapeutic effects demonstrated in well-conducted, placebo-controlled, randomized clinical trials of these probiotic Lactobacillus strains. What is known about the antimicrobial activities supported by the molecules secreted by such probiotic Lactobacillus strains suggests that they constitute a promising new source for the development of innovative anti-infectious agents that act luminally and intracellularly in the gastrointestinal tract.

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Section: Therapeutic Effects Against Various Forms Of Acute Diarrheamentioning

confidence: 99%

Section: Therapeutic Effects Against Various Forms Of Acute Diarrheamentioning

confidence: 99%

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

2014

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“…The strongest evidence of a beneficial effect of probiotics has been established with L. rhamnosus GG and B. lactis BB-12 for prevention and L. reuteri SD2222 for treatment (51,52,62,80,122,131,138) of acute diarrhea mainly caused by rotaviruses in children ( Table 1). The study designs cited are similar, randomized, double blinded, and placebo controlled.…”

Section: Probiotics For Newborns and Childrenmentioning

confidence: 99%

“…Note also that unlike many pharmaceutical treatments, there were no significant side effects reported. In a European study, faster hospital discharge was achieved in addition to improvement in clinical outcome (51). Two hundred ninety-one children 1 to 3 months of age were randomly allocated to receive oral rehydration solution plus placebo or 10 10 L. rhamnosus GG.…”

Section: Probiotics For Newborns and Childrenmentioning

confidence: 99%

Potential Uses of Probiotics in Clinical Practice

Reid

Jaß

Sebulsky³

et al. 2003

Clin Microbiol Rev

738

450

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Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. There is now mounting evidence that selected probiotic strains can provide health benefits to their human hosts. Numerous clinical trials show that certain strains can improve the outcome of intestinal infections by reducing the duration of diarrhea. Further investigations have shown benefits in reducing the recurrence of urogenital infections in women, while promising studies in cancer and allergies require research into the mechanisms of activity for particular strains and better-designed trials. At present, only a small percentage of physicians either know of probiotics or understand their potential applicability to patient care. Thus, probiotics are not yet part of the clinical arsenal for prevention and treatment of disease or maintenance of health. The establishment of accepted standards and guidelines, proposed by the Food and Agriculture Organization of the United Nations and the World Health Organization, represents a key step in ensuring that reliable products with suitable, informative health claims become available. Based upon the evidence to date, future advances with single- and multiple-strain therapies are on the horizon for the management of a number of debilitating and even fatal conditions

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“…Among many validated useful characteristics, research most commonly acknowledges positive aspects in the treatment of acute and chronic diarrhea in children and adults (Isolauri et al, 1991;Guandalini et al, 2000;Gupta et al, 2000;Saavedra, 2000).…”

Section: Introductionmentioning

confidence: 99%

The use of Probiotics in Horses with Gastrointestinal Disease

Gotić¹,

Grden²,

Babić³

et al. 2017

American Journal of Animal and Veterinary Sciences

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Probiotics are common adjunctive therapy used in human and veterinary medicine, mostly intended for gastrointestinal diseases treatment or prevention. Lactic acid bacteria: Lactobacilli, bifid bacteria and enterococci and Saccharomyces boulardii, a subtype of the nonpathogenic yeast have been most frequently used as probiotic active ingredients. To become a recognized effective probiotic, a certain microorganism must fulfill many expectations, primarily the ability to survive gastrointestinal tract passage, adhere to epithelial cells and colonize intestines to present antimicrobial effect and inhibition of enteric pathogens. Prior to evaluation of clinical efficiency, it is advised to perform in vitro studies in order to identify potentially beneficial properties of probiotic organisms. An effective probiotic product could be of a great value in equine medicine, since both, adult horses and foals, frequently exhibit gastrointestinal problems. However, very little objective research has been carried out on the topic. The effectiveness of probiotic products in horses has been proven in very few studies and some presented serious adverse effects. Therefore, the benefits of probiotics use in equine medicine still remain undetermined.

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Lactobacillus GG Administered in Oral Rehydration Solution to Children with Acute Diarrhea: A Multicenter European Trial

Abstract: Administering oral rehydration solution containing Lactobacillus GG to children with acute diarrhea is safe and results in shorter duration of diarrhea, less chance of a protracted course, and faster discharge from the hospital.

Cited by 533 publications

References 21 publications

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

Anti-Infective Activities of Lactobacillus Strains in the Human Intestinal Microbiota: from Probiotics to Gastrointestinal Anti-Infectious Biotherapeutic Agents

Potential Uses of Probiotics in Clinical Practice

The use of Probiotics in Horses with Gastrointestinal Disease

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